Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms
Source at https://doi.org/10.3389/fgene.2019.00794. Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten feed pellets and undigested f...
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Online Access: | https://hdl.handle.net/10037/16301 https://doi.org/10.3389/fgene.2019.00794 |
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ftunivtroemsoe:oai:munin.uit.no:10037/16301 2023-05-15T15:27:25+02:00 Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms Olsvik, Pål Asgeir Larsen, Anett Kristin Berntssen, Marc Goksøyr, Anders Karlsen, Odd Andre Yadetie, Fekadu Sanden, Monica Kristensen, Torstein 2019-09-26 https://hdl.handle.net/10037/16301 https://doi.org/10.3389/fgene.2019.00794 eng eng Frontiers Media Frontiers in Genetics info:eu-repo/grantAgreement/RCN/MARINFORSK/244564/Norway/iCod 2.0: Integrative environmental genomics of Atlantic cod (Gadus morhua); a holistic approach to characterize the biological effects of// info:eu-repo/grantAgreement/RCN/BIOTEK2021/248840/Norway/dCod 1.0: decoding systems toxicology of cod (Gadus morhua) - environmental genomics for ecosystem quality monitoring and risk assessment// Olsvik, P.A., Larsen, A.K., Berntssen, M.H.G., Goksøyr, A., Karlsen, O.A. Yadetie, F. . Kristensen, T. (2019). Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms. Frontiers in Genetics, 10 :794. https://doi.org/10.3389/fgene.2019.00794 FRIDAID 1731709 doi:10.3389/fgene.2019.00794 1664-8021 https://hdl.handle.net/10037/16301 openAccess VDP::Landbruks- og fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922 VDP::Agriculture and fisheries science: 900::Fisheries science: 920::Aquaculture: 922 VDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi : 489 VDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Eco-toxicology: 489 aquaculture fish feed insecticides chlorpyrifos-methyl wild fish exposure metabolomics transcriptomics Journal article Tidsskriftartikkel Peer reviewed 2019 ftunivtroemsoe https://doi.org/10.3389/fgene.2019.00794 2021-06-25T17:56:52Z Source at https://doi.org/10.3389/fgene.2019.00794. Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten feed pellets and undigested feces deposited beneath the net pens represent a source of contamination for marine organisms. To examine the impacts of long-term and continuous dietary exposure to an organophosphorus pesticide found in Atlantic salmon feed, we fed juvenile Atlantic cod ( Gadus morhua ), an abundant species around North Atlantic fish farms, three concentrations (0.5, 4.2, and 23.2 mg/kg) of chlorpyrifos-methyl (CPM) for 30 days. Endpoints included liver and bile bioaccumulation, liver transcriptomics and metabolomics, as well as plasma cholinesterase activity, cortisol, liver 7-ethoxyresor-ufin-O-deethylase activity, and hypoxia tolerance. The results show that Atlantic cod can accumulate relatively high levels of CPM in liver after continuous exposure, which is then metabolized and excreted via the bile. All three exposure concentrations lead to significant inhibition of plasma cholinesterase activity, the primary target of CPM. Transcriptomics profiling pointed to effects on cholesterol and steroid biosynthesis. Metabolite profiling revealed that CPM induced responses reflecting detoxification by glutathione-S-transferase, inhibition of monoacylglycerol lipase, potential inhibition of carboxylesterase, and increased demand for ATP, followed by secondary inflammatory responses. A gradual hypoxia challenge test showed that all groups of exposed fish were less tolerant to low oxygen saturation than the controls. In conclusion, this study suggests that wild fish continuously feeding on leftover pellets near fish farms over time may be vulnerable to organophosphorus pesticides. Article in Journal/Newspaper atlantic cod Atlantic salmon Gadus morhua North Atlantic University of Tromsø: Munin Open Research Archive Slaughter ENVELOPE(-85.633,-85.633,-78.617,-78.617) Frontiers in Genetics 10 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Landbruks- og fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922 VDP::Agriculture and fisheries science: 900::Fisheries science: 920::Aquaculture: 922 VDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi : 489 VDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Eco-toxicology: 489 aquaculture fish feed insecticides chlorpyrifos-methyl wild fish exposure metabolomics transcriptomics |
spellingShingle |
VDP::Landbruks- og fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922 VDP::Agriculture and fisheries science: 900::Fisheries science: 920::Aquaculture: 922 VDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi : 489 VDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Eco-toxicology: 489 aquaculture fish feed insecticides chlorpyrifos-methyl wild fish exposure metabolomics transcriptomics Olsvik, Pål Asgeir Larsen, Anett Kristin Berntssen, Marc Goksøyr, Anders Karlsen, Odd Andre Yadetie, Fekadu Sanden, Monica Kristensen, Torstein Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
topic_facet |
VDP::Landbruks- og fiskerifag: 900::Fiskerifag: 920::Akvakultur: 922 VDP::Agriculture and fisheries science: 900::Fisheries science: 920::Aquaculture: 922 VDP::Matematikk og naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi : 489 VDP::Mathematics and natural scienses: 400::Zoology and botany: 480::Eco-toxicology: 489 aquaculture fish feed insecticides chlorpyrifos-methyl wild fish exposure metabolomics transcriptomics |
description |
Source at https://doi.org/10.3389/fgene.2019.00794. Screening has revealed that modern-day feeds used in Atlantic salmon aquaculture might contain trace amounts of agricultural pesticides. To reach slaughter size, salmon are produced in open net pens in the sea. Uneaten feed pellets and undigested feces deposited beneath the net pens represent a source of contamination for marine organisms. To examine the impacts of long-term and continuous dietary exposure to an organophosphorus pesticide found in Atlantic salmon feed, we fed juvenile Atlantic cod ( Gadus morhua ), an abundant species around North Atlantic fish farms, three concentrations (0.5, 4.2, and 23.2 mg/kg) of chlorpyrifos-methyl (CPM) for 30 days. Endpoints included liver and bile bioaccumulation, liver transcriptomics and metabolomics, as well as plasma cholinesterase activity, cortisol, liver 7-ethoxyresor-ufin-O-deethylase activity, and hypoxia tolerance. The results show that Atlantic cod can accumulate relatively high levels of CPM in liver after continuous exposure, which is then metabolized and excreted via the bile. All three exposure concentrations lead to significant inhibition of plasma cholinesterase activity, the primary target of CPM. Transcriptomics profiling pointed to effects on cholesterol and steroid biosynthesis. Metabolite profiling revealed that CPM induced responses reflecting detoxification by glutathione-S-transferase, inhibition of monoacylglycerol lipase, potential inhibition of carboxylesterase, and increased demand for ATP, followed by secondary inflammatory responses. A gradual hypoxia challenge test showed that all groups of exposed fish were less tolerant to low oxygen saturation than the controls. In conclusion, this study suggests that wild fish continuously feeding on leftover pellets near fish farms over time may be vulnerable to organophosphorus pesticides. |
format |
Article in Journal/Newspaper |
author |
Olsvik, Pål Asgeir Larsen, Anett Kristin Berntssen, Marc Goksøyr, Anders Karlsen, Odd Andre Yadetie, Fekadu Sanden, Monica Kristensen, Torstein |
author_facet |
Olsvik, Pål Asgeir Larsen, Anett Kristin Berntssen, Marc Goksøyr, Anders Karlsen, Odd Andre Yadetie, Fekadu Sanden, Monica Kristensen, Torstein |
author_sort |
Olsvik, Pål Asgeir |
title |
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
title_short |
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
title_full |
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
title_fullStr |
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
title_full_unstemmed |
Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms |
title_sort |
effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms |
publisher |
Frontiers Media |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/16301 https://doi.org/10.3389/fgene.2019.00794 |
long_lat |
ENVELOPE(-85.633,-85.633,-78.617,-78.617) |
geographic |
Slaughter |
geographic_facet |
Slaughter |
genre |
atlantic cod Atlantic salmon Gadus morhua North Atlantic |
genre_facet |
atlantic cod Atlantic salmon Gadus morhua North Atlantic |
op_relation |
Frontiers in Genetics info:eu-repo/grantAgreement/RCN/MARINFORSK/244564/Norway/iCod 2.0: Integrative environmental genomics of Atlantic cod (Gadus morhua); a holistic approach to characterize the biological effects of// info:eu-repo/grantAgreement/RCN/BIOTEK2021/248840/Norway/dCod 1.0: decoding systems toxicology of cod (Gadus morhua) - environmental genomics for ecosystem quality monitoring and risk assessment// Olsvik, P.A., Larsen, A.K., Berntssen, M.H.G., Goksøyr, A., Karlsen, O.A. Yadetie, F. . Kristensen, T. (2019). Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms. Frontiers in Genetics, 10 :794. https://doi.org/10.3389/fgene.2019.00794 FRIDAID 1731709 doi:10.3389/fgene.2019.00794 1664-8021 https://hdl.handle.net/10037/16301 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3389/fgene.2019.00794 |
container_title |
Frontiers in Genetics |
container_volume |
10 |
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1766357862452297728 |