Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population
Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, ele...
Main Author: | |
---|---|
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Published: |
UiT The Arctic University of Norway
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/15611 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/15611 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/15611 2023-05-15T18:34:57+02:00 Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population Stefansson, Vidar Tor Nyborg 2019-06-11 https://hdl.handle.net/10037/15611 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper I: Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study. BMC Nephrology, 17 , 172. Also available in Munin at https://hdl.handle.net/10037/10163 . Paper II: Stefansson V.T.N., Schei, J., Solbu, M.D., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general population. Kidney International, 93 (5), 1183-1190. Also available at https://doi.org/10.1016/j.kint.2017.11.012 . Paper III: Melsom, T., Stefansson V., Schei, J., Solbu, M., Jenssen, T.G., Wilsgaard, T. & Eriksen, B.O. (2016). Association of Increasing GFR with Change in Albuminuria in the General Population. Clinical Journal of the American Society of Nephrology, 11 (12), 2186-2194. Also available at https://doi.org/10.2215/CJN.04940516 . https://hdl.handle.net/10037/15611 openAccess Copyright 2019 The Author(s) VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 Obesity Ageing Glomerular filtration rate Hyperfiltration Metabolic syndrome Albuminuria Chronic kidney disease Epidemiology The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2019 ftunivtroemsoe 2021-06-25T17:56:38Z Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, elevated triglycerides and lowered high-density lipoprotein cholesterol levels. Both obesity and the metabolic syndrome are known risk factors for chronic kidney disease and end-stage renal disease, but their effect on kidney function before reaching those disease states is less clear. The results from previous studies on these subjects are divergent and inconclusive. The concept of hyperfiltration, a state of elevated GFR (glomerular filtration rate, a measure of kidney function), may contribute to the inconsistency of research results on the subject. Hyperfiltration is present in diabetes, obesity and hypertension, and is a state of distress which may cause kidney damage in the long term. In the short and medium term, however, it may present as higher or increasing GFR. It may also cause albuminuria, which is an early marker of endothelial damage. In this thesis, the association between obesity, the metabolic syndrome, changes in GFR and hyperfiltration were explored in the population-based Renal Iohexol Clearance Survey. GFR was measured with an accurate method (iohexol clearance) in 1627 persons in 2007-09 and repeated in 1324 of the same persons in 2013-15. The relationship between changes in GFR and changes in albuminuria was also explored, to further explore the concept of hyperfiltration as an increase in GFR over time. We found that obesity was associated with hyperfiltration, but not with accelerated GFR decline. Increased albuminuria was associated with increased GFR. The metabolic syndrome was associated with accelerated GFR decline. The results point to hyperfiltration as an important factor in the relationship between obesity and GFR, and that hyperfiltration is associated with albuminuria. Doctoral or Postdoctoral Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 Obesity Ageing Glomerular filtration rate Hyperfiltration Metabolic syndrome Albuminuria Chronic kidney disease Epidemiology The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 Obesity Ageing Glomerular filtration rate Hyperfiltration Metabolic syndrome Albuminuria Chronic kidney disease Epidemiology The Tromsø Study Tromsøundersøkelsen DOKTOR-003 Stefansson, Vidar Tor Nyborg Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 Obesity Ageing Glomerular filtration rate Hyperfiltration Metabolic syndrome Albuminuria Chronic kidney disease Epidemiology The Tromsø Study Tromsøundersøkelsen DOKTOR-003 |
description |
Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, elevated triglycerides and lowered high-density lipoprotein cholesterol levels. Both obesity and the metabolic syndrome are known risk factors for chronic kidney disease and end-stage renal disease, but their effect on kidney function before reaching those disease states is less clear. The results from previous studies on these subjects are divergent and inconclusive. The concept of hyperfiltration, a state of elevated GFR (glomerular filtration rate, a measure of kidney function), may contribute to the inconsistency of research results on the subject. Hyperfiltration is present in diabetes, obesity and hypertension, and is a state of distress which may cause kidney damage in the long term. In the short and medium term, however, it may present as higher or increasing GFR. It may also cause albuminuria, which is an early marker of endothelial damage. In this thesis, the association between obesity, the metabolic syndrome, changes in GFR and hyperfiltration were explored in the population-based Renal Iohexol Clearance Survey. GFR was measured with an accurate method (iohexol clearance) in 1627 persons in 2007-09 and repeated in 1324 of the same persons in 2013-15. The relationship between changes in GFR and changes in albuminuria was also explored, to further explore the concept of hyperfiltration as an increase in GFR over time. We found that obesity was associated with hyperfiltration, but not with accelerated GFR decline. Increased albuminuria was associated with increased GFR. The metabolic syndrome was associated with accelerated GFR decline. The results point to hyperfiltration as an important factor in the relationship between obesity and GFR, and that hyperfiltration is associated with albuminuria. |
format |
Doctoral or Postdoctoral Thesis |
author |
Stefansson, Vidar Tor Nyborg |
author_facet |
Stefansson, Vidar Tor Nyborg |
author_sort |
Stefansson, Vidar Tor Nyborg |
title |
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
title_short |
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
title_full |
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
title_fullStr |
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
title_full_unstemmed |
Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
title_sort |
obesity, renal hyperfiltration and glomerular filtration rate decline in the general population |
publisher |
UiT The Arctic University of Norway |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/15611 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Paper I: Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study. BMC Nephrology, 17 , 172. Also available in Munin at https://hdl.handle.net/10037/10163 . Paper II: Stefansson V.T.N., Schei, J., Solbu, M.D., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Metabolic syndrome but not obesity measures are risk factors for accelerated age-related glomerular filtration rate decline in the general population. Kidney International, 93 (5), 1183-1190. Also available at https://doi.org/10.1016/j.kint.2017.11.012 . Paper III: Melsom, T., Stefansson V., Schei, J., Solbu, M., Jenssen, T.G., Wilsgaard, T. & Eriksen, B.O. (2016). Association of Increasing GFR with Change in Albuminuria in the General Population. Clinical Journal of the American Society of Nephrology, 11 (12), 2186-2194. Also available at https://doi.org/10.2215/CJN.04940516 . https://hdl.handle.net/10037/15611 |
op_rights |
openAccess Copyright 2019 The Author(s) |
_version_ |
1766219980580323328 |