Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children
This is an Accepted Manuscript of an article published by Taylor & Francis in the Journal of Asthma on 8 October 2014, available online at https://doi.org/10.3109/02770903.2014.966914 . Aim: A questionnaire has been used repeatedly in cross-sectional studies to determine the prevalence of asthma...
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ftunivtroemsoe:oai:munin.uit.no:10037/15377 2023-05-15T17:24:42+02:00 Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children Hansen, Tonje Elisabeth Evjenth, Bjørg Holt, Jan 2014-10-08 https://hdl.handle.net/10037/15377 https://doi.org/10.3109/02770903.2014.966914 eng eng Taylor & Francis Hansen, T.E. (2019). The prevalence and possible risk factors of asthma in a subarctic child population. A study of asthma and allergy among schoolchildren i Nordland county. (Doctoral thesis). https://hdl.handle.net/10037/15313 Journal of Asthma Hansen, T.E., Evjenth, B. & Holt, J. (2015). Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children. Journal of Asthma, 52 (3), 262-267. https://doi.org/10.3109/02770903.2014.966914 FRIDAID 1218120 doi:10.3109/02770903.2014.966914 0277-0903 1532-4303 https://hdl.handle.net/10037/15377 openAccess VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Atopy Cross-sectional Epidemiology Instrument validation Reliability Journal article Tidsskriftartikkel Peer reviewed 2014 ftunivtroemsoe https://doi.org/10.3109/02770903.2014.966914 2021-06-25T17:56:35Z This is an Accepted Manuscript of an article published by Taylor & Francis in the Journal of Asthma on 8 October 2014, available online at https://doi.org/10.3109/02770903.2014.966914 . Aim: A questionnaire has been used repeatedly in cross-sectional studies to determine the prevalence of asthma, allergic rhinoconjunctivitis (AR) and eczema among schoolchildren in Nordland County, Norway. The current study was designed to validate the questionnaire against clinical assessment as the diagnostic gold standard and to investigate the extent of possible misclassification. Methods: A subsample of 801 schoolchildren of 4150, whose parents had answered a questionnaire covering asthma and atopic diseases, underwent a detailed clinical evaluation including a standardized interview, a clinical examination, skin prick tests (SPT), blood samples, spirometry an exercise treadmill test (EIB test) and measurement of exhaled nitrogen oxide (FeNO). Results: The questionnaire had a sensitivity of 0.96 and a specificity of 0.87 for the diagnosis of asthma ever compared to clinical assessment. The overall agreement (kappa) was 0.80. After clinical assessment the prevalence of asthma ever was adjusted from 17.6 % to 16.9 % (95% CI: 15.8–18.0). The most sensitive and specific questions in identifying asthmatic children by the questionnaire were questions asking about diagnosis (‘Has the child ever had asthma?’) rather than those covering asthma symptoms such as wheeze, shortness of breath and/or cough. A positive exercise test increased the post-test probability for the asthma diagnosis only to a minimal degree. Conclusion: Based on the good agreement between the questionnaire responses and the clinical assessments, it is concluded that the questionnaire had good validity and served as a useful epidemiological tool. Detailed clinical testing added little additional information. Article in Journal/Newspaper Nordland Nordland Nordland University of Tromsø: Munin Open Research Archive Norway Journal of Asthma 52 3 262 267 |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Atopy Cross-sectional Epidemiology Instrument validation Reliability |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Atopy Cross-sectional Epidemiology Instrument validation Reliability Hansen, Tonje Elisabeth Evjenth, Bjørg Holt, Jan Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Atopy Cross-sectional Epidemiology Instrument validation Reliability |
description |
This is an Accepted Manuscript of an article published by Taylor & Francis in the Journal of Asthma on 8 October 2014, available online at https://doi.org/10.3109/02770903.2014.966914 . Aim: A questionnaire has been used repeatedly in cross-sectional studies to determine the prevalence of asthma, allergic rhinoconjunctivitis (AR) and eczema among schoolchildren in Nordland County, Norway. The current study was designed to validate the questionnaire against clinical assessment as the diagnostic gold standard and to investigate the extent of possible misclassification. Methods: A subsample of 801 schoolchildren of 4150, whose parents had answered a questionnaire covering asthma and atopic diseases, underwent a detailed clinical evaluation including a standardized interview, a clinical examination, skin prick tests (SPT), blood samples, spirometry an exercise treadmill test (EIB test) and measurement of exhaled nitrogen oxide (FeNO). Results: The questionnaire had a sensitivity of 0.96 and a specificity of 0.87 for the diagnosis of asthma ever compared to clinical assessment. The overall agreement (kappa) was 0.80. After clinical assessment the prevalence of asthma ever was adjusted from 17.6 % to 16.9 % (95% CI: 15.8–18.0). The most sensitive and specific questions in identifying asthmatic children by the questionnaire were questions asking about diagnosis (‘Has the child ever had asthma?’) rather than those covering asthma symptoms such as wheeze, shortness of breath and/or cough. A positive exercise test increased the post-test probability for the asthma diagnosis only to a minimal degree. Conclusion: Based on the good agreement between the questionnaire responses and the clinical assessments, it is concluded that the questionnaire had good validity and served as a useful epidemiological tool. Detailed clinical testing added little additional information. |
format |
Article in Journal/Newspaper |
author |
Hansen, Tonje Elisabeth Evjenth, Bjørg Holt, Jan |
author_facet |
Hansen, Tonje Elisabeth Evjenth, Bjørg Holt, Jan |
author_sort |
Hansen, Tonje Elisabeth |
title |
Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
title_short |
Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
title_full |
Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
title_fullStr |
Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
title_full_unstemmed |
Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
title_sort |
validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children |
publisher |
Taylor & Francis |
publishDate |
2014 |
url |
https://hdl.handle.net/10037/15377 https://doi.org/10.3109/02770903.2014.966914 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Nordland Nordland Nordland |
genre_facet |
Nordland Nordland Nordland |
op_relation |
Hansen, T.E. (2019). The prevalence and possible risk factors of asthma in a subarctic child population. A study of asthma and allergy among schoolchildren i Nordland county. (Doctoral thesis). https://hdl.handle.net/10037/15313 Journal of Asthma Hansen, T.E., Evjenth, B. & Holt, J. (2015). Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children. Journal of Asthma, 52 (3), 262-267. https://doi.org/10.3109/02770903.2014.966914 FRIDAID 1218120 doi:10.3109/02770903.2014.966914 0277-0903 1532-4303 https://hdl.handle.net/10037/15377 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3109/02770903.2014.966914 |
container_title |
Journal of Asthma |
container_volume |
52 |
container_issue |
3 |
container_start_page |
262 |
op_container_end_page |
267 |
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1766115807875563520 |