Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs
Background : Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives : To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–20...
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Online Access: | https://hdl.handle.net/10037/15193 https://doi.org/10.1016/j.envres.2019.02.047 |
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ftunivtroemsoe:oai:munin.uit.no:10037/15193 2023-05-15T14:27:53+02:00 Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M 2019-03-01 https://hdl.handle.net/10037/15193 https://doi.org/10.1016/j.envres.2019.02.047 eng eng Elsevier Environmental Research info:eu-repo/grantAgreement/RCN/MILJØFORSK/244298/Norway/Development, Evaluation and Application of a Nested Exposure Assessment Model for Organic Contaminants in the Nordic and Arctic Region// Nøst, T.H., Berg, V., Hanssen, L., Rylander, C., Gaudreau, E., Dumas, P., . Sandanger, T.M. (2019). Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs. Environmental Research, 172 , 684-692. https://doi.org/10.1016/j.envres.2019.02.047 FRIDAID 1682389 doi:10.1016/j.envres.2019.02.047 0013-9351 1096-0953 https://hdl.handle.net/10037/15193 openAccess © 2019 The Authors. VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Cross-sectional time trends POPs Human biomonitoring Study design Modeling Journal article Tidsskriftartikkel Peer reviewed 2019 ftunivtroemsoe https://doi.org/10.1016/j.envres.2019.02.047 2021-06-25T17:56:30Z Background : Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives : To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) to model-estimated values. A second objective was to compare the repeated cross-sectional time trends with those observed in our previous longitudinal study using repeated individual measurements in older men from the same surveys. Methods : Serum from 45 persons aged 30 years in each of the following years: 1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted concentrations of PCB-153 in each sampling year were derived using the emission-based CoZMoMAN model. Results : The median decreases in summed serum POP concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were − 71%, − 81%, and − 86% for women and − 65%, − 77%, and − 87% for men, respectively. The overall time trend in predicted PCB-153 concentrations demonstrated agreement with the observed trend although model predictions were higher than the measured concentrations at all time points. Compared to our previous longitudinal study of repeated individual measurements in older men, similar although more prominent declines were observed in the younger cross-sectional samples. Discussion : Observed declines in serum concentrations from 1986 to 2007 were substantial for legacy POPs in men and women at reproductive ages in Northern Norway and are generally consistent with previous longitudinal biomonitoring efforts in the study population. The measured concentrations and observed declines likely reflect a combination of recent and historic exposures. Small differences in time trends observed between the studies could be attributed to different study designs (i.e. the chosen age group or sex and cross-sectional versus repeated individual measurement sampling). Article in Journal/Newspaper Arctic Northern Norway Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø Environmental Research 172 684 692 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Cross-sectional time trends POPs Human biomonitoring Study design Modeling |
spellingShingle |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Cross-sectional time trends POPs Human biomonitoring Study design Modeling Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
topic_facet |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Cross-sectional time trends POPs Human biomonitoring Study design Modeling |
description |
Background : Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks. Objectives : To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) to model-estimated values. A second objective was to compare the repeated cross-sectional time trends with those observed in our previous longitudinal study using repeated individual measurements in older men from the same surveys. Methods : Serum from 45 persons aged 30 years in each of the following years: 1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted concentrations of PCB-153 in each sampling year were derived using the emission-based CoZMoMAN model. Results : The median decreases in summed serum POP concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were − 71%, − 81%, and − 86% for women and − 65%, − 77%, and − 87% for men, respectively. The overall time trend in predicted PCB-153 concentrations demonstrated agreement with the observed trend although model predictions were higher than the measured concentrations at all time points. Compared to our previous longitudinal study of repeated individual measurements in older men, similar although more prominent declines were observed in the younger cross-sectional samples. Discussion : Observed declines in serum concentrations from 1986 to 2007 were substantial for legacy POPs in men and women at reproductive ages in Northern Norway and are generally consistent with previous longitudinal biomonitoring efforts in the study population. The measured concentrations and observed declines likely reflect a combination of recent and historic exposures. Small differences in time trends observed between the studies could be attributed to different study designs (i.e. the chosen age group or sex and cross-sectional versus repeated individual measurement sampling). |
format |
Article in Journal/Newspaper |
author |
Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M |
author_facet |
Nøst, Therese Haugdahl Berg, Vivian Hanssen, Linda Rylander, Charlotta Gaudreau, Eric Dumas, Pierre Breivik, Knut Sandanger, Torkjel M |
author_sort |
Nøst, Therese Haugdahl |
title |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
title_short |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
title_full |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
title_fullStr |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
title_full_unstemmed |
Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs |
title_sort |
time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in northern norway: measurements, mechanistic modeling and a comparison of study designs |
publisher |
Elsevier |
publishDate |
2019 |
url |
https://hdl.handle.net/10037/15193 https://doi.org/10.1016/j.envres.2019.02.047 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Arctic Northern Norway Tromsø |
genre_facet |
Arctic Northern Norway Tromsø |
op_relation |
Environmental Research info:eu-repo/grantAgreement/RCN/MILJØFORSK/244298/Norway/Development, Evaluation and Application of a Nested Exposure Assessment Model for Organic Contaminants in the Nordic and Arctic Region// Nøst, T.H., Berg, V., Hanssen, L., Rylander, C., Gaudreau, E., Dumas, P., . Sandanger, T.M. (2019). Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: measurements, mechanistic modeling and a comparison of study designs. Environmental Research, 172 , 684-692. https://doi.org/10.1016/j.envres.2019.02.047 FRIDAID 1682389 doi:10.1016/j.envres.2019.02.047 0013-9351 1096-0953 https://hdl.handle.net/10037/15193 |
op_rights |
openAccess © 2019 The Authors. |
op_doi |
https://doi.org/10.1016/j.envres.2019.02.047 |
container_title |
Environmental Research |
container_volume |
172 |
container_start_page |
684 |
op_container_end_page |
692 |
_version_ |
1766301953599471616 |