Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
Source at https://doi.org/10.1016/j.ekir.2017.11.020 . Introduction : Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. Methods : W...
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ftunivtroemsoe:oai:munin.uit.no:10037/14948 2023-05-15T18:34:54+02:00 Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline Schei, Jørgen Fuskevåg, Ole-Martin Stefansson, Vidar Tor Nyborg Solbu, Marit Dahl Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf 2017-12-07 https://hdl.handle.net/10037/14948 https://doi.org/10.1016/j.ekir.2017.11.020 eng eng Elsevier Kidney International Reports Schei, J., Fuskevåg, O., Stefansson, V.T.N., Solbu, M.D., Jenssen, T.G., Eriksen, B.O. & Melsom, T. (2018). Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline. Kidney International Reports, 3 (3), 573-582. https://doi.org/10.1016/j.ekir.2017.11.020 FRIDAID 1593146 doi:10.1016/j.ekir.2017.11.020 2468-0249 https://hdl.handle.net/10037/14948 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 aging albuminuria epidemiology GFR decline oxidative stress kidney function decline Journal article Tidsskriftartikkel Peer reviewed 2017 ftunivtroemsoe https://doi.org/10.1016/j.ekir.2017.11.020 2021-06-25T17:56:26Z Source at https://doi.org/10.1016/j.ekir.2017.11.020 . Introduction : Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. Methods : We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and oxidative RNA damage (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) was associated with the age-related glomerular filtration rate (GFR) decline or incident low-grade albuminuria during a median of 5.6 years of follow-up. In the Renal Iohexol Clearance Survey in the Sixth Tromsø Study, we measured GFR using iohexol clearance in 1591 participants without renal disease, diabetes, or cardiovascular disease. Low-grade albuminuria was defined as an albumin-creatinine ratio >1.13 mg/mmol. Results : The mean (SD) annual GFR change was −0.84 (2.00) ml/min per 1.73 m2 per year. In linear mixed models, urinary 8-oxodG and 8-oxoGuo levels were not associated with the GFR change rate. In a multivariable adjusted logistic regression model, a baseline urinary 8-oxoGuo in the highest quartile was associated with an increased risk of low-grade albuminuria at follow-up (odds ratio: 2.64; 95% confidence interval: 1.50–4.65). When the highest quartile of urinary 8-oxoGuo was added to the baseline model, the area under the receiver operating characteristics curve for predicting low-grade albuminuria at follow-up improved from 0.67 to 0.71 (P = 0.002). Conclusion : Oxidative stress measured as urinary 8-oxoGuo excretion was independently associated with incident low-grade albuminuria, but neither 8-oxoGuo nor 8-oxodG predicted an accelerated age-related GFR decline in a cohort representative of the middle-aged general population during almost 6 years of follow-up. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Kidney International Reports 3 3 573 582 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 aging albuminuria epidemiology GFR decline oxidative stress kidney function decline |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 aging albuminuria epidemiology GFR decline oxidative stress kidney function decline Schei, Jørgen Fuskevåg, Ole-Martin Stefansson, Vidar Tor Nyborg Solbu, Marit Dahl Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology urology: 772 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi urologi: 772 aging albuminuria epidemiology GFR decline oxidative stress kidney function decline |
description |
Source at https://doi.org/10.1016/j.ekir.2017.11.020 . Introduction : Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. Methods : We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and oxidative RNA damage (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) was associated with the age-related glomerular filtration rate (GFR) decline or incident low-grade albuminuria during a median of 5.6 years of follow-up. In the Renal Iohexol Clearance Survey in the Sixth Tromsø Study, we measured GFR using iohexol clearance in 1591 participants without renal disease, diabetes, or cardiovascular disease. Low-grade albuminuria was defined as an albumin-creatinine ratio >1.13 mg/mmol. Results : The mean (SD) annual GFR change was −0.84 (2.00) ml/min per 1.73 m2 per year. In linear mixed models, urinary 8-oxodG and 8-oxoGuo levels were not associated with the GFR change rate. In a multivariable adjusted logistic regression model, a baseline urinary 8-oxoGuo in the highest quartile was associated with an increased risk of low-grade albuminuria at follow-up (odds ratio: 2.64; 95% confidence interval: 1.50–4.65). When the highest quartile of urinary 8-oxoGuo was added to the baseline model, the area under the receiver operating characteristics curve for predicting low-grade albuminuria at follow-up improved from 0.67 to 0.71 (P = 0.002). Conclusion : Oxidative stress measured as urinary 8-oxoGuo excretion was independently associated with incident low-grade albuminuria, but neither 8-oxoGuo nor 8-oxodG predicted an accelerated age-related GFR decline in a cohort representative of the middle-aged general population during almost 6 years of follow-up. |
format |
Article in Journal/Newspaper |
author |
Schei, Jørgen Fuskevåg, Ole-Martin Stefansson, Vidar Tor Nyborg Solbu, Marit Dahl Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf |
author_facet |
Schei, Jørgen Fuskevåg, Ole-Martin Stefansson, Vidar Tor Nyborg Solbu, Marit Dahl Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf |
author_sort |
Schei, Jørgen |
title |
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
title_short |
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
title_full |
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
title_fullStr |
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
title_full_unstemmed |
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline |
title_sort |
urinary markers of oxidative stress are associated with albuminuria but not gfr decline |
publisher |
Elsevier |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/14948 https://doi.org/10.1016/j.ekir.2017.11.020 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Kidney International Reports Schei, J., Fuskevåg, O., Stefansson, V.T.N., Solbu, M.D., Jenssen, T.G., Eriksen, B.O. & Melsom, T. (2018). Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline. Kidney International Reports, 3 (3), 573-582. https://doi.org/10.1016/j.ekir.2017.11.020 FRIDAID 1593146 doi:10.1016/j.ekir.2017.11.020 2468-0249 https://hdl.handle.net/10037/14948 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1016/j.ekir.2017.11.020 |
container_title |
Kidney International Reports |
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3 |
container_issue |
3 |
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573 |
op_container_end_page |
582 |
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1766219881142812672 |