Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016
This is the peer reviewed version of the following article: Langholz, P.L., Strand, B.H., Cook, S. & Hopstock, L.A. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics...
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Online Access: | https://hdl.handle.net/10037/14661 https://doi.org/10.1111/ggi.13447 |
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ftunivtroemsoe:oai:munin.uit.no:10037/14661 2023-05-15T18:34:26+02:00 Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter 2018-05-29 https://hdl.handle.net/10037/14661 https://doi.org/10.1111/ggi.13447 eng eng Wiley Geriatrics & Gerontology International Langholz, P.L., Strand, B.H., Cook, S. & Hopstock, L.A. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International, 18 (8), 1200-1205. https://doi.org/10.1111/ggi.13447 FRIDAID 1587836 doi:10.1111/ggi.13447 1444-1586 1447-0594 https://hdl.handle.net/10037/14661 openAccess VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 cohort studies epidemiology frail elderly mortality Norway Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1111/ggi.13447 2021-06-25T17:56:19Z This is the peer reviewed version of the following article: Langholz, P.L., Strand, B.H., Cook, S. & Hopstock, L.A. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International, 18 (8), 1200-1205, which has been published in final form at https://doi.org/10.1111/ggi.13447 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Aim : There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all‐cause mortality in men and women in a Norwegian cohort study. Methods : We followed 712 participants (52% women) aged ≥70 years participating in the population‐based Tromsø 5 Study in 2001–2002 for all‐cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried's frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education. Results : In total, 3.8% (n = 27) of participants were frail (women 4.4%, men 3.2%) and 38.1% (n = 271) were pre‐frail (women 45.8%, men 29.9%). During follow‐up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail older adults (multivariable‐adjusted HR 4.16, 95% CI 2.40–7.22) compared with non‐frail older adults. In sex‐stratified analysis, the adjusted HR was 7.09 (95% CI 3.03–16.58) for frail men and 2.93 (95% CI 1.38–6.22) for frail women. Results for pre‐frailty showed an overall weaker association with mortality. Conclusions : While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. Geriatr Gerontol Int 2018; 18: 1200–1205. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø Geriatrics & Gerontology International 18 8 1200 1205 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 cohort studies epidemiology frail elderly mortality Norway |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 cohort studies epidemiology frail elderly mortality Norway Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 cohort studies epidemiology frail elderly mortality Norway |
description |
This is the peer reviewed version of the following article: Langholz, P.L., Strand, B.H., Cook, S. & Hopstock, L.A. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International, 18 (8), 1200-1205, which has been published in final form at https://doi.org/10.1111/ggi.13447 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Aim : There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all‐cause mortality in men and women in a Norwegian cohort study. Methods : We followed 712 participants (52% women) aged ≥70 years participating in the population‐based Tromsø 5 Study in 2001–2002 for all‐cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried's frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education. Results : In total, 3.8% (n = 27) of participants were frail (women 4.4%, men 3.2%) and 38.1% (n = 271) were pre‐frail (women 45.8%, men 29.9%). During follow‐up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail older adults (multivariable‐adjusted HR 4.16, 95% CI 2.40–7.22) compared with non‐frail older adults. In sex‐stratified analysis, the adjusted HR was 7.09 (95% CI 3.03–16.58) for frail men and 2.93 (95% CI 1.38–6.22) for frail women. Results for pre‐frailty showed an overall weaker association with mortality. Conclusions : While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. Geriatr Gerontol Int 2018; 18: 1200–1205. |
format |
Article in Journal/Newspaper |
author |
Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter |
author_facet |
Langholz, Petja Strand, Bjørn Heine Cook, Sarah Hopstock, Laila Arnesdatter |
author_sort |
Langholz, Petja |
title |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_short |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_full |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_fullStr |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_full_unstemmed |
Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016 |
title_sort |
frailty phenotype and its association with all-cause mortality in community-dwelling norwegian women and men aged 70 years and older: the tromsø study 2001–2016 |
publisher |
Wiley |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14661 https://doi.org/10.1111/ggi.13447 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Geriatrics & Gerontology International Langholz, P.L., Strand, B.H., Cook, S. & Hopstock, L.A. (2018). Frailty phenotype and its association with all-cause mortality in community-dwelling Norwegian women and men aged 70 years and older: The Tromsø Study 2001–2016. Geriatrics & Gerontology International, 18 (8), 1200-1205. https://doi.org/10.1111/ggi.13447 FRIDAID 1587836 doi:10.1111/ggi.13447 1444-1586 1447-0594 https://hdl.handle.net/10037/14661 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1111/ggi.13447 |
container_title |
Geriatrics & Gerontology International |
container_volume |
18 |
container_issue |
8 |
container_start_page |
1200 |
op_container_end_page |
1205 |
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