Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study
Source at: http://doi.org/10.1055/s-0038-1651523 Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic infl...
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Online Access: | https://hdl.handle.net/10037/14445 https://doi.org/10.1055/s-0038-1651523 |
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ftunivtroemsoe:oai:munin.uit.no:10037/14445 2023-05-15T18:34:31+02:00 Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study Lappegård, Jostein Ellingsen, Trygve Hindberg, Kristian Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Løchen, Maja-Lisa Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2018-04-10 https://hdl.handle.net/10037/14445 https://doi.org/10.1055/s-0038-1651523 eng eng Thieme TH Open Lappegård, J., Ellingsen, T., Hindberg, K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., . Hansen, J.-B. (2018). Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study. TH Open , 2018, e182-e189. http://doi.org/10.1055/s-0038-1651523 FRIDAID 1585908 doi:10.1055/s-0038-1651523 2512-9465 https://hdl.handle.net/10037/14445 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1055/s-0038-1651523 2021-06-25T17:56:19Z Source at: http://doi.org/10.1055/s-0038-1651523 Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP were obtained from 5,765 individuals attending a population-based cohort study. We followed participants from inclusion in the fourth survey of the Tromsø Study (1994/95) until December 31st 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI 1.14-1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI 1.20- 2.24) compared to subjects in the lowest quintile. RDW mediated 7.2% (95% CI 4.0- 30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI 0.98-1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI 1.06-1.97) compared to subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø TH Open 02 02 e182 e189 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 Lappegård, Jostein Ellingsen, Trygve Hindberg, Kristian Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Løchen, Maja-Lisa Brækkan, Sigrid Kufaas Hansen, John-Bjarne Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 |
description |
Source at: http://doi.org/10.1055/s-0038-1651523 Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP were obtained from 5,765 individuals attending a population-based cohort study. We followed participants from inclusion in the fourth survey of the Tromsø Study (1994/95) until December 31st 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI 1.14-1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI 1.20- 2.24) compared to subjects in the lowest quintile. RDW mediated 7.2% (95% CI 4.0- 30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI 0.98-1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI 1.06-1.97) compared to subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD. |
format |
Article in Journal/Newspaper |
author |
Lappegård, Jostein Ellingsen, Trygve Hindberg, Kristian Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Løchen, Maja-Lisa Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Lappegård, Jostein Ellingsen, Trygve Hindberg, Kristian Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Løchen, Maja-Lisa Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Lappegård, Jostein |
title |
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
title_short |
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
title_full |
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
title_fullStr |
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
title_full_unstemmed |
Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study |
title_sort |
impact of chronic inflammation, assessed by hs-crp, on the association between red cell distribution width and arterial cardiovascular disease: the tromsø study |
publisher |
Thieme |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14445 https://doi.org/10.1055/s-0038-1651523 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
TH Open Lappegård, J., Ellingsen, T., Hindberg, K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., . Hansen, J.-B. (2018). Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study. TH Open , 2018, e182-e189. http://doi.org/10.1055/s-0038-1651523 FRIDAID 1585908 doi:10.1055/s-0038-1651523 2512-9465 https://hdl.handle.net/10037/14445 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1055/s-0038-1651523 |
container_title |
TH Open |
container_volume |
02 |
container_issue |
02 |
container_start_page |
e182 |
op_container_end_page |
e189 |
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1766219303422525440 |