Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems
Accepted manuscript version. Published version available at https://doi.org/10.1016/j.envpol.2018.11.097 . Licensed CC BY-NC-ND 4.0. Marine mammals in the Barents Sea region have among the highest levels of contaminants recorded in the Arctic and the Atlantic walrus ( Odobenus rosmarus rosmarus ) is...
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Language: | English |
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Online Access: | https://hdl.handle.net/10037/14328 https://doi.org/10.1016/j.envpol.2018.11.097 |
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ftunivtroemsoe:oai:munin.uit.no:10037/14328 2023-05-15T15:09:51+02:00 Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems Routti, Heli Diot, Beatrice Panti, Cristina Duale, Nur Fossi, Maria Cristina Harju, Mikael Kovacs, Kit M. Lydersen, Christian Scotter, Sophie Villanger, Gro Dehli Bourgeon, Sophie 2018-11-30 https://hdl.handle.net/10037/14328 https://doi.org/10.1016/j.envpol.2018.11.097 eng eng Elsevier Environmental Pollution info:eu-repo/grantAgreement/RCN/KLIMAFORSK/273470/Norway/Effects of pollutants in Svalbard marine mammals faced by the climate change - collaboration between Norway and Italy// Routti, H., Diot, B., Panti, C., Duale, N., Fossi, M.C., Harju, M., . Bourgeon, S. (2018). Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems. Environmental Pollution . https://doi.org/10.1016/j.envpol.2018.11.097 FRIDAID 1642207 doi:10.1016/j.envpol.2018.11.097 0269-7491 1873-6424 https://hdl.handle.net/10037/14328 openAccess VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Pollutant marine mammal thyroid hormone qPCR mRNA Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1016/j.envpol.2018.11.097 2021-06-25T17:56:14Z Accepted manuscript version. Published version available at https://doi.org/10.1016/j.envpol.2018.11.097 . Licensed CC BY-NC-ND 4.0. Marine mammals in the Barents Sea region have among the highest levels of contaminants recorded in the Arctic and the Atlantic walrus ( Odobenus rosmarus rosmarus ) is one of the most contaminated species within this region. We therefore investigated the relationships bewteen blubber concentrations of lipophilic persistent organic pollutants (POPs) and plasma concentrations of perfluoroalkyl substances (PFASs) and markers of endocrine and immune functions in adult male Atlantic walruses (n = 38) from Svalbard, Norway. To do so, we assessed plasma concentrations of five forms of thyroid hormones and transcript levels of genes related to the endocrine and immune systems as endpoints; transcript levels of seven genes in blubber and 23 genes in blood cells were studied. Results indicated that plasma total thyroxine (TT4) concentrations decreased with increasing blubber concentrations of lipophilic POPs. Blood cell transcript levels of genes involved in the function of T and B cells (FC like receptors 2 and 5, cytotoxic T-lymphocyte associated protein 4 and protein tyrosine phosphatase non-receptor type 22) were increased with plasma PFAS concentrations. These results suggest that changes in thyroid and immune systems in adult male walruses are linked to current levels of contaminant exposure. Article in Journal/Newspaper Arctic Barents Sea Odobenus rosmarus Svalbard walrus* University of Tromsø: Munin Open Research Archive Arctic Barents Sea Norway Svalbard Environmental Pollution 246 658 667 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Pollutant marine mammal thyroid hormone qPCR mRNA |
spellingShingle |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Pollutant marine mammal thyroid hormone qPCR mRNA Routti, Heli Diot, Beatrice Panti, Cristina Duale, Nur Fossi, Maria Cristina Harju, Mikael Kovacs, Kit M. Lydersen, Christian Scotter, Sophie Villanger, Gro Dehli Bourgeon, Sophie Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
topic_facet |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 Pollutant marine mammal thyroid hormone qPCR mRNA |
description |
Accepted manuscript version. Published version available at https://doi.org/10.1016/j.envpol.2018.11.097 . Licensed CC BY-NC-ND 4.0. Marine mammals in the Barents Sea region have among the highest levels of contaminants recorded in the Arctic and the Atlantic walrus ( Odobenus rosmarus rosmarus ) is one of the most contaminated species within this region. We therefore investigated the relationships bewteen blubber concentrations of lipophilic persistent organic pollutants (POPs) and plasma concentrations of perfluoroalkyl substances (PFASs) and markers of endocrine and immune functions in adult male Atlantic walruses (n = 38) from Svalbard, Norway. To do so, we assessed plasma concentrations of five forms of thyroid hormones and transcript levels of genes related to the endocrine and immune systems as endpoints; transcript levels of seven genes in blubber and 23 genes in blood cells were studied. Results indicated that plasma total thyroxine (TT4) concentrations decreased with increasing blubber concentrations of lipophilic POPs. Blood cell transcript levels of genes involved in the function of T and B cells (FC like receptors 2 and 5, cytotoxic T-lymphocyte associated protein 4 and protein tyrosine phosphatase non-receptor type 22) were increased with plasma PFAS concentrations. These results suggest that changes in thyroid and immune systems in adult male walruses are linked to current levels of contaminant exposure. |
format |
Article in Journal/Newspaper |
author |
Routti, Heli Diot, Beatrice Panti, Cristina Duale, Nur Fossi, Maria Cristina Harju, Mikael Kovacs, Kit M. Lydersen, Christian Scotter, Sophie Villanger, Gro Dehli Bourgeon, Sophie |
author_facet |
Routti, Heli Diot, Beatrice Panti, Cristina Duale, Nur Fossi, Maria Cristina Harju, Mikael Kovacs, Kit M. Lydersen, Christian Scotter, Sophie Villanger, Gro Dehli Bourgeon, Sophie |
author_sort |
Routti, Heli |
title |
Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
title_short |
Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
title_full |
Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
title_fullStr |
Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
title_full_unstemmed |
Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems |
title_sort |
contaminants in atlantic walruses part 2: relationships with endocrine and immune systems |
publisher |
Elsevier |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14328 https://doi.org/10.1016/j.envpol.2018.11.097 |
geographic |
Arctic Barents Sea Norway Svalbard |
geographic_facet |
Arctic Barents Sea Norway Svalbard |
genre |
Arctic Barents Sea Odobenus rosmarus Svalbard walrus* |
genre_facet |
Arctic Barents Sea Odobenus rosmarus Svalbard walrus* |
op_relation |
Environmental Pollution info:eu-repo/grantAgreement/RCN/KLIMAFORSK/273470/Norway/Effects of pollutants in Svalbard marine mammals faced by the climate change - collaboration between Norway and Italy// Routti, H., Diot, B., Panti, C., Duale, N., Fossi, M.C., Harju, M., . Bourgeon, S. (2018). Contaminants in Atlantic walruses Part 2: Relationships with endocrine and immune systems. Environmental Pollution . https://doi.org/10.1016/j.envpol.2018.11.097 FRIDAID 1642207 doi:10.1016/j.envpol.2018.11.097 0269-7491 1873-6424 https://hdl.handle.net/10037/14328 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1016/j.envpol.2018.11.097 |
container_title |
Environmental Pollution |
container_volume |
246 |
container_start_page |
658 |
op_container_end_page |
667 |
_version_ |
1766340961650081792 |