Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis
This paper is part of Marit Waaseth's ph.d. thesis which is available in Munin at http://hdl.handle.net/10037/2646 Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT us...
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ftunivtroemsoe:oai:munin.uit.no:10037/1424 2024-06-02T08:15:21+00:00 Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis Waaseth, Marit Bakken, Kjersti Dumeaux, Vanessa Olsen, Karina Standahl Rylander, Charlotta Figenschaug, Yngve Lund, Eiliv 2008-02-14 358812 bytes application/pdf https://hdl.handle.net/10037/1424 https://doi.org/10.1186/1472-6874-8-1 eng eng BioMed Central BMC Women's Health 8(2008) article no 1 doi:10.1186/1472-6874-8-1 1472-6874 https://hdl.handle.net/10037/1424 URN:NBN:no-uit_munin_1201 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 Journal article Tidsskriftartikkel Peer reviewed 2008 ftunivtroemsoe https://doi.org/10.1186/1472-6874-8-1 2024-05-07T08:41:49Z This paper is part of Marit Waaseth's ph.d. thesis which is available in Munin at http://hdl.handle.net/10037/2646 Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: We conducted a cross-sectional study of sex hormone levels among 445 women aged 48–62 who answered an eight-page questionnaire in 2004 and agreed to donate a blood sample. The samples were drawn at the women's local general physician's offices in the spring of 2005 and sent by mail to NOWAC, Tromsø, together with a two-page questionnaire. Plasma levels of sex hormones and Sex Hormone Binding Globulin (SHBG) were measured by immunometry. 20 samples were excluded, leaving 425 hormone measurements. Results: 20% of postmenopausal women were HRT users. The plasma levels of estradiol (E2) increased with an increased E2 dose, and use of systemic E2-containing HRT suppressed the level of Follicle Stimulating Hormone (FSH). SHBG levels increased mainly among users of oral E2 preparations. Vaginal E2 application did not influence hormone levels. There was no difference in BMI between HRT users and non-users. Increased BMI was associated with increased E2 and decreased FSH and SHBG levels among non-users. Menopausal status defined by the twopage questionnaire showed 92% sensitivity (95% CI 89–96%) and 73% specificity (95% CI 64–82%), while the eightpage questionnaire showed 88% sensitivity (95% CI 84–92%) and 87% specificity (95% CI 80–94%). Current HRT use showed 100% specificity and 88% of the HRT-users had plasma E2 levels above the 95% CI of non-users. Conclusion: Users of systemic E2-containing HRT preparations have plasma E2 and FSH levels comparable to premenopausal women. BMI has an influence on hormone ... Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø BMC Women's Health 8 1 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 |
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VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 Waaseth, Marit Bakken, Kjersti Dumeaux, Vanessa Olsen, Karina Standahl Rylander, Charlotta Figenschaug, Yngve Lund, Eiliv Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 |
description |
This paper is part of Marit Waaseth's ph.d. thesis which is available in Munin at http://hdl.handle.net/10037/2646 Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: We conducted a cross-sectional study of sex hormone levels among 445 women aged 48–62 who answered an eight-page questionnaire in 2004 and agreed to donate a blood sample. The samples were drawn at the women's local general physician's offices in the spring of 2005 and sent by mail to NOWAC, Tromsø, together with a two-page questionnaire. Plasma levels of sex hormones and Sex Hormone Binding Globulin (SHBG) were measured by immunometry. 20 samples were excluded, leaving 425 hormone measurements. Results: 20% of postmenopausal women were HRT users. The plasma levels of estradiol (E2) increased with an increased E2 dose, and use of systemic E2-containing HRT suppressed the level of Follicle Stimulating Hormone (FSH). SHBG levels increased mainly among users of oral E2 preparations. Vaginal E2 application did not influence hormone levels. There was no difference in BMI between HRT users and non-users. Increased BMI was associated with increased E2 and decreased FSH and SHBG levels among non-users. Menopausal status defined by the twopage questionnaire showed 92% sensitivity (95% CI 89–96%) and 73% specificity (95% CI 64–82%), while the eightpage questionnaire showed 88% sensitivity (95% CI 84–92%) and 87% specificity (95% CI 80–94%). Current HRT use showed 100% specificity and 88% of the HRT-users had plasma E2 levels above the 95% CI of non-users. Conclusion: Users of systemic E2-containing HRT preparations have plasma E2 and FSH levels comparable to premenopausal women. BMI has an influence on hormone ... |
format |
Article in Journal/Newspaper |
author |
Waaseth, Marit Bakken, Kjersti Dumeaux, Vanessa Olsen, Karina Standahl Rylander, Charlotta Figenschaug, Yngve Lund, Eiliv |
author_facet |
Waaseth, Marit Bakken, Kjersti Dumeaux, Vanessa Olsen, Karina Standahl Rylander, Charlotta Figenschaug, Yngve Lund, Eiliv |
author_sort |
Waaseth, Marit |
title |
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
title_short |
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
title_full |
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
title_fullStr |
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
title_full_unstemmed |
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis |
title_sort |
hormone replacement therapy use and plasma levels of sex hormones in the norwegian women and cancer postgenome cohort : a cross-sectional analysis |
publisher |
BioMed Central |
publishDate |
2008 |
url |
https://hdl.handle.net/10037/1424 https://doi.org/10.1186/1472-6874-8-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
BMC Women's Health 8(2008) article no 1 doi:10.1186/1472-6874-8-1 1472-6874 https://hdl.handle.net/10037/1424 URN:NBN:no-uit_munin_1201 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/1472-6874-8-1 |
container_title |
BMC Women's Health |
container_volume |
8 |
container_issue |
1 |
_version_ |
1800739496817328128 |