Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study
Source at: http://doi.org/10.1186/s12937-018-0364-8 Background: Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against develop...
Published in: | Nutrition Journal |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2018
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/14136 https://doi.org/10.1186/s12937-018-0364-8 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/14136 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/14136 2023-05-15T18:34:57+02:00 Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study Johnsen, Stein Harald Jacobsen, Bjarne K. Brækkan, Sigrid Kufaas Hansen, John-Bjarne Mathiesen, Ellisiv B. 2018-05-25 https://hdl.handle.net/10037/14136 https://doi.org/10.1186/s12937-018-0364-8 eng eng BMC Nutrition Journal Johnsen, S. H., Jacobsen, B. K., Brækkan, S. K., Hansen, J.-B. & Mathiesen, E. B. (2018). Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study. Nutrition Journal, 17 (56). http://doi.org/10.1186/s12937-018-0364-8 FRIDAID 1587300 doi:10.1186/s12937-018-0364-8 1475-2891 https://hdl.handle.net/10037/14136 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1186/s12937-018-0364-8 2021-06-25T17:56:10Z Source at: http://doi.org/10.1186/s12937-018-0364-8 Background: Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size. Methods: We obtained questionnaire-based information on fish consumption and carotid ultrasonography from 3900 persons aged 45–74 years. The questionnaires were validated by measuring serum concentrations of PUFAs and triglycerides in a subgroup. At follow-up seven years later, 2983 (76%) went through a second ultrasound scanning. Logistic regression and general linear models were used to analyze the outcome (plaque presence and plaque area) as a function of fish consumption, including analyses stratified on fish oil supplements. Results: At baseline, lean fish intake < 1 time/week vs. 1–1.9 times/week was associated with risk of plaque (OR 1.34, 95% CI 1.03–1.76). Fatty fish intake and use of fish oil supplements were not statistically significantly associated with atherosclerosis at baseline. In persons without plaque at baseline, total fish consumption ≥3 times/week vs. 1–1.9 times/week was associated with risk of novel plaque (OR 1.32, 95% CI 1.01–1.73) and larger plaque area (1.76 mm2 vs. 1.46 mm2 , p = 0.02) at follow-up. Adjustments for use of fish oil supplements had no impact on the associations, and no interactions were seen between total, fatty or lean fish consumption and fish oil intake. Conclusions: We found no protective effect of fatty fish eating or fish oil supplements on atherosclerotic plaque formation or plaque area in a general population. Lean fish consumption was associated with a reduced risk for plaque in cross-sectional analysis, suggesting that the beneficial effects of fish consumption on atherosclerosis may be mediated through other mechanisms than n-3 PUFAs. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Nutrition Journal 17 1 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Johnsen, Stein Harald Jacobsen, Bjarne K. Brækkan, Sigrid Kufaas Hansen, John-Bjarne Mathiesen, Ellisiv B. Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Source at: http://doi.org/10.1186/s12937-018-0364-8 Background: Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size. Methods: We obtained questionnaire-based information on fish consumption and carotid ultrasonography from 3900 persons aged 45–74 years. The questionnaires were validated by measuring serum concentrations of PUFAs and triglycerides in a subgroup. At follow-up seven years later, 2983 (76%) went through a second ultrasound scanning. Logistic regression and general linear models were used to analyze the outcome (plaque presence and plaque area) as a function of fish consumption, including analyses stratified on fish oil supplements. Results: At baseline, lean fish intake < 1 time/week vs. 1–1.9 times/week was associated with risk of plaque (OR 1.34, 95% CI 1.03–1.76). Fatty fish intake and use of fish oil supplements were not statistically significantly associated with atherosclerosis at baseline. In persons without plaque at baseline, total fish consumption ≥3 times/week vs. 1–1.9 times/week was associated with risk of novel plaque (OR 1.32, 95% CI 1.01–1.73) and larger plaque area (1.76 mm2 vs. 1.46 mm2 , p = 0.02) at follow-up. Adjustments for use of fish oil supplements had no impact on the associations, and no interactions were seen between total, fatty or lean fish consumption and fish oil intake. Conclusions: We found no protective effect of fatty fish eating or fish oil supplements on atherosclerotic plaque formation or plaque area in a general population. Lean fish consumption was associated with a reduced risk for plaque in cross-sectional analysis, suggesting that the beneficial effects of fish consumption on atherosclerosis may be mediated through other mechanisms than n-3 PUFAs. |
format |
Article in Journal/Newspaper |
author |
Johnsen, Stein Harald Jacobsen, Bjarne K. Brækkan, Sigrid Kufaas Hansen, John-Bjarne Mathiesen, Ellisiv B. |
author_facet |
Johnsen, Stein Harald Jacobsen, Bjarne K. Brækkan, Sigrid Kufaas Hansen, John-Bjarne Mathiesen, Ellisiv B. |
author_sort |
Johnsen, Stein Harald |
title |
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
title_short |
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
title_full |
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
title_fullStr |
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
title_full_unstemmed |
Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study |
title_sort |
fish consumption, fish oil supplements and risk of atherosclerosis in the tromsø study |
publisher |
BMC |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14136 https://doi.org/10.1186/s12937-018-0364-8 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Nutrition Journal Johnsen, S. H., Jacobsen, B. K., Brækkan, S. K., Hansen, J.-B. & Mathiesen, E. B. (2018). Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study. Nutrition Journal, 17 (56). http://doi.org/10.1186/s12937-018-0364-8 FRIDAID 1587300 doi:10.1186/s12937-018-0364-8 1475-2891 https://hdl.handle.net/10037/14136 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12937-018-0364-8 |
container_title |
Nutrition Journal |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766219979660722176 |