Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study
Source at https://doi.org/10.1161/JAHA.117.008414 . Background : Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and Results : Data from the fourth s...
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Online Access: | https://hdl.handle.net/10037/14116 https://doi.org/10.1161/JAHA.117.008414 |
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ftunivtroemsoe:oai:munin.uit.no:10037/14116 2023-05-15T18:34:31+02:00 Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study Ball, Jocasta Løchen, Maja-Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila Arnesdatter Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina 2018-04-19 https://hdl.handle.net/10037/14116 https://doi.org/10.1161/JAHA.117.008414 eng eng Wiley Open Access Journal of the American Heart Association Ball, J., Løchen, M.-L., Wilsgaard, T., Schirmer, H., Hopstock, L.A., Morseth, B., . Sharashova, E. (2018). Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study. Journal of the American Heart Association , 7(9). https://doi.org/10.1161/JAHA.117.008414 FRIDAID 1581769 doi:10.1161/JAHA.117.008414 2047-9980 https://hdl.handle.net/10037/14116 openAccess VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 incidence atrial fibrillation sex differences body mass index Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1161/JAHA.117.008414 2021-06-25T17:56:12Z Source at https://doi.org/10.1161/JAHA.117.008414 . Background : Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and Results : Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications. Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. Conclusions : Within a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø Journal of the American Heart Association 7 9 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 incidence atrial fibrillation sex differences body mass index |
spellingShingle |
VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 incidence atrial fibrillation sex differences body mass index Ball, Jocasta Løchen, Maja-Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila Arnesdatter Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800 VDP::Medisinske Fag: 700::Helsefag: 800 incidence atrial fibrillation sex differences body mass index |
description |
Source at https://doi.org/10.1161/JAHA.117.008414 . Background : Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated. Methods and Results : Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, data from individuals who attended the third and fourth study surveys were used. AF diagnosis was derived from record linkage and end point adjudication. Cox regression analysis was conducted using fractional polynomials of BMI and BMI change with models adjusted for age, baseline BMI (change analyses), risk factors, comorbidities, and antihypertensive medications. Data were available for 24 799 individuals from the fourth survey (mean age, 45.5±14.2 years; 52.9% women). Over 15.7±5.5 years, 811 women (6.2%) and 918 men (7.9%) developed AF. In men, lower BMI decreased AF risk and higher BMI increased risk (hazard ratios [95% confidence intervals] for BMI 18 or 40 kg/m2 compared with 23 kg/m2 were 0.75 [0.70–0.81] and 4.42 [3.00–6.53], respectively). The same pattern was identified in women. Two surveys were attended by 14 652 individuals. In men and women, a decrease in BMI over time was associated with decreased AF risk and an increase in BMI was associated with increased AF risk. Conclusions : Within a population cohort, BMI was positively associated with AF risk. Change in BMI over time influenced AF risk in both men and women. |
format |
Article in Journal/Newspaper |
author |
Ball, Jocasta Løchen, Maja-Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila Arnesdatter Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina |
author_facet |
Ball, Jocasta Løchen, Maja-Lisa Wilsgaard, Tom Schirmer, Henrik Hopstock, Laila Arnesdatter Morseth, Bente Mathiesen, Ellisiv B. Njølstad, Inger Tiwari, Sweta Sharashova, Ekaterina |
author_sort |
Ball, Jocasta |
title |
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
title_short |
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
title_full |
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
title_fullStr |
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
title_full_unstemmed |
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study |
title_sort |
sex differences in the impact of body mass index on the risk of future atrial fibrillation: insights from the longitudinal population-based tromsø study |
publisher |
Wiley Open Access |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14116 https://doi.org/10.1161/JAHA.117.008414 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of the American Heart Association Ball, J., Løchen, M.-L., Wilsgaard, T., Schirmer, H., Hopstock, L.A., Morseth, B., . Sharashova, E. (2018). Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study. Journal of the American Heart Association , 7(9). https://doi.org/10.1161/JAHA.117.008414 FRIDAID 1581769 doi:10.1161/JAHA.117.008414 2047-9980 https://hdl.handle.net/10037/14116 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1161/JAHA.117.008414 |
container_title |
Journal of the American Heart Association |
container_volume |
7 |
container_issue |
9 |
_version_ |
1766219303055523840 |