Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study
Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Bi...
Published in: | International Journal of Environmental Research and Public Health |
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Language: | English |
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UiT The Arctic University of Norway
2018
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Online Access: | https://hdl.handle.net/10037/14071 |
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ftunivtroemsoe:oai:munin.uit.no:10037/14071 2023-05-15T15:55:29+02:00 Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study Kovalenko, Anton Alexandrovich 2018-11-12 https://hdl.handle.net/10037/14071 eng eng UiT The Arctic University of Norway UiT Norges arktiske universitet Paper I: Kovalenko, A, Brenn, T., Odland, J.Ø., Nieboer, E., Krettek, A. & Anda E.E. (2017). Under-reporting of major birth defects in Northwest Russia: a registry-based study. International journal of Circumpolar Health, 76 (1), 1366785. Also available at http://hdl.handle.net/10037/12287. Paper II: Kovalenko, A., Brenn, T., Odland, J.Ø., Nieboer, E., Krettek, A. & Anda, E.E. Risk Factors for Hypospadias in Northwest Russia: a Murmansk County Birth Registry Study. (Manuscript). Paper III: Kovalenko, A., Anda, E.E., Odland. J.Ø., Nieboer, E., Brenn, T. & Krettek, A. (2018). Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study. International Journal of Environmental Research and Public Health, 15 (7), e1320. Also available at https://doi.org/10.3390/ijerph15071320. ISM skriftserie; 196 https://hdl.handle.net/10037/14071 openAccess Copyright 2018 The Author(s) VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 DOKTOR-003 Doctoral thesis Doktorgradsavhandling 2018 ftunivtroemsoe 2023-02-23T00:04:25Z Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Birth Registry (MCBR) and the Murmansk Regional Congenital Defects Registry (MRCDR) to investigate the epidemiology and selected risk factors for congenital malformations. The study population included all 52 806 births recorded in the MCBR during 2006-2011 and were followed up to two years after birth through MRCDR. Chi-squared tests were applied to evaluate differences in distribution of selected risk factors. Logistic regression was used to estimate the effect of risk factors on the occurrence of some defects. Routine under-reporting of major birth defects to the MRCDR of 40% cases occurred in Murmansk County. Hypospadias was the most common birth defect with a prevalence of 25.7 per 10 000 newborns and the cases were associated with cervical erosion, low infant birthweight and preeclampsia. Smoking, alcohol abuse during pregnancy and maternal diabetes mellitus were also risk factors for delivering infants with ventricular septal defects. Potentially numerous cases of hypospadias and ventricular septal defects are preventable in Russia if health policy makers were to give more attention to established risks. Public health efforts should therefore focus on reducing smoking and alcohol consumption, as well as improving diabetes control in pregnant women. Doctoral or Postdoctoral Thesis Circumpolar Health International Journal of Circumpolar Health Northwest Russia University of Tromsø: Munin Open Research Archive Murmansk International Journal of Environmental Research and Public Health 15 7 1320 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 DOKTOR-003 |
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VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 DOKTOR-003 Kovalenko, Anton Alexandrovich Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
topic_facet |
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 DOKTOR-003 |
description |
Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Birth Registry (MCBR) and the Murmansk Regional Congenital Defects Registry (MRCDR) to investigate the epidemiology and selected risk factors for congenital malformations. The study population included all 52 806 births recorded in the MCBR during 2006-2011 and were followed up to two years after birth through MRCDR. Chi-squared tests were applied to evaluate differences in distribution of selected risk factors. Logistic regression was used to estimate the effect of risk factors on the occurrence of some defects. Routine under-reporting of major birth defects to the MRCDR of 40% cases occurred in Murmansk County. Hypospadias was the most common birth defect with a prevalence of 25.7 per 10 000 newborns and the cases were associated with cervical erosion, low infant birthweight and preeclampsia. Smoking, alcohol abuse during pregnancy and maternal diabetes mellitus were also risk factors for delivering infants with ventricular septal defects. Potentially numerous cases of hypospadias and ventricular septal defects are preventable in Russia if health policy makers were to give more attention to established risks. Public health efforts should therefore focus on reducing smoking and alcohol consumption, as well as improving diabetes control in pregnant women. |
format |
Doctoral or Postdoctoral Thesis |
author |
Kovalenko, Anton Alexandrovich |
author_facet |
Kovalenko, Anton Alexandrovich |
author_sort |
Kovalenko, Anton Alexandrovich |
title |
Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
title_short |
Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
title_full |
Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
title_fullStr |
Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
title_full_unstemmed |
Epidemiology and new opportunities of investigating risk factors for congenital malformations in Northwest Russia: a registry-based linkage study |
title_sort |
epidemiology and new opportunities of investigating risk factors for congenital malformations in northwest russia: a registry-based linkage study |
publisher |
UiT The Arctic University of Norway |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14071 |
geographic |
Murmansk |
geographic_facet |
Murmansk |
genre |
Circumpolar Health International Journal of Circumpolar Health Northwest Russia |
genre_facet |
Circumpolar Health International Journal of Circumpolar Health Northwest Russia |
op_relation |
Paper I: Kovalenko, A, Brenn, T., Odland, J.Ø., Nieboer, E., Krettek, A. & Anda E.E. (2017). Under-reporting of major birth defects in Northwest Russia: a registry-based study. International journal of Circumpolar Health, 76 (1), 1366785. Also available at http://hdl.handle.net/10037/12287. Paper II: Kovalenko, A., Brenn, T., Odland, J.Ø., Nieboer, E., Krettek, A. & Anda, E.E. Risk Factors for Hypospadias in Northwest Russia: a Murmansk County Birth Registry Study. (Manuscript). Paper III: Kovalenko, A., Anda, E.E., Odland. J.Ø., Nieboer, E., Brenn, T. & Krettek, A. (2018). Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study. International Journal of Environmental Research and Public Health, 15 (7), e1320. Also available at https://doi.org/10.3390/ijerph15071320. ISM skriftserie; 196 https://hdl.handle.net/10037/14071 |
op_rights |
openAccess Copyright 2018 The Author(s) |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
15 |
container_issue |
7 |
container_start_page |
1320 |
_version_ |
1766390970817970176 |