Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients
Background: There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. Methods: Demographic data, clinical data and blo...
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ftunivtroemsoe:oai:munin.uit.no:10037/14055 2023-05-15T18:34:57+02:00 Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients Bugge, Erlend Wynn, Rolf Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Grønli, Ole Kristian 2018-09-27 https://hdl.handle.net/10037/14055 https://doi.org/10.1186/s12888-018-1900-y eng eng BMC Bugge, E. (2022). Some systemic markers of inflammation in older adults with psychiatric disorders. (Doctoral thesis). https://hdl.handle.net/10037/27311 . BMC Psychiatry Bugge, E., Wynn, R., Mollnes, T. E., Reitan, S. M. K & Grønli, O. K. (2018). Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients. BMC Psychiatry, 18(315), 1-7. http://doi.org/10.1186/s12888-018-1900-y FRIDAID 1611824 doi:10.1186/s12888-018-1900-y 1471-244X https://hdl.handle.net/10037/14055 openAccess VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry child psychiatry: 757 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri barnepsykiatri: 757 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.1186/s12888-018-1900-y 2022-11-10T00:01:31Z Background: There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. Methods: Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 years, consecutively admitted to a psychiatric hospital in Tromsø, Norway (69°N). Results: The most common diagnosis was Recurrent depressive disorder (26.5%), the second most common was dementia in Alzheimer’s disease (20.4%). The most frequent somatic disease was cardiovascular disease (28%). No statistical association (p < 0.01) was found between cytokines and gender, age, BMI, anti-inflammatory drugs, psychotropic drugs, reason for admittance, smoking, vitamin supplements, alcohol consumption, length of stay, somatic disease (present/not-present) or psychiatric diagnoses. However, when allocating patients to two groups, depression and no depression, we found higher levels of 10 cytokines in the no depression group (FDR-p < 0.0044). Possibly, this could in part be explained by the higher prevalence of cardiovascular disease (CVD) and dementia in the no depression group, as these factors were significant predictors of patients being categorized as not depressed in a logistic regression. In addition, other unknown factors might have contributed to the association between no depression and elevated cytokines. On the other hand, the high level of psychiatric and somatic comorbidity in the study population may have led to increased levels of cytokines in general, possibly diluting the potential effect of other factors, depression included, on the cytokine levels. The size of the study, and particularly the size of the subgroups, represents a limitation of the study, as do the general heterogeneity and the lack of a control group. Conclusions: There was no significant difference in cytokine levels between various psychiatric diagnoses in ... Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø BMC Psychiatry 18 1 |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry child psychiatry: 757 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri barnepsykiatri: 757 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 |
spellingShingle |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry child psychiatry: 757 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri barnepsykiatri: 757 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 Bugge, Erlend Wynn, Rolf Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Grønli, Ole Kristian Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
topic_facet |
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry child psychiatry: 757 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri barnepsykiatri: 757 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Geriatrics: 778 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 |
description |
Background: There is a paucity of studies on inflammatory markers in elderly psychiatric patients. Hence, our study was undertaken to investigate cytokines as biomarkers in diagnostically unselected elderly patients admitted to a psychiatric hospital. Methods: Demographic data, clinical data and blood samples, including 27 cytokines, were collected from 98 patients above 60 years, consecutively admitted to a psychiatric hospital in Tromsø, Norway (69°N). Results: The most common diagnosis was Recurrent depressive disorder (26.5%), the second most common was dementia in Alzheimer’s disease (20.4%). The most frequent somatic disease was cardiovascular disease (28%). No statistical association (p < 0.01) was found between cytokines and gender, age, BMI, anti-inflammatory drugs, psychotropic drugs, reason for admittance, smoking, vitamin supplements, alcohol consumption, length of stay, somatic disease (present/not-present) or psychiatric diagnoses. However, when allocating patients to two groups, depression and no depression, we found higher levels of 10 cytokines in the no depression group (FDR-p < 0.0044). Possibly, this could in part be explained by the higher prevalence of cardiovascular disease (CVD) and dementia in the no depression group, as these factors were significant predictors of patients being categorized as not depressed in a logistic regression. In addition, other unknown factors might have contributed to the association between no depression and elevated cytokines. On the other hand, the high level of psychiatric and somatic comorbidity in the study population may have led to increased levels of cytokines in general, possibly diluting the potential effect of other factors, depression included, on the cytokine levels. The size of the study, and particularly the size of the subgroups, represents a limitation of the study, as do the general heterogeneity and the lack of a control group. Conclusions: There was no significant difference in cytokine levels between various psychiatric diagnoses in ... |
format |
Article in Journal/Newspaper |
author |
Bugge, Erlend Wynn, Rolf Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Grønli, Ole Kristian |
author_facet |
Bugge, Erlend Wynn, Rolf Mollnes, Tom Eirik Reitan, Solveig Merete Klæbo Grønli, Ole Kristian |
author_sort |
Bugge, Erlend |
title |
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
title_short |
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
title_full |
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
title_fullStr |
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
title_full_unstemmed |
Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
title_sort |
cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients |
publisher |
BMC |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/14055 https://doi.org/10.1186/s12888-018-1900-y |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Bugge, E. (2022). Some systemic markers of inflammation in older adults with psychiatric disorders. (Doctoral thesis). https://hdl.handle.net/10037/27311 . BMC Psychiatry Bugge, E., Wynn, R., Mollnes, T. E., Reitan, S. M. K & Grønli, O. K. (2018). Cytokine profiles and diagnoses in elderly, hospitalised psychiatric patients. BMC Psychiatry, 18(315), 1-7. http://doi.org/10.1186/s12888-018-1900-y FRIDAID 1611824 doi:10.1186/s12888-018-1900-y 1471-244X https://hdl.handle.net/10037/14055 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12888-018-1900-y |
container_title |
BMC Psychiatry |
container_volume |
18 |
container_issue |
1 |
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1766219962271137792 |