Antioxidant defenses in polar cod (Boreogadus saida) and responsiveness toward dietary crude oil exposure

Accepted manuscript version. Published version available at https://doi.org/10.1016/j.marenvres.2017.06.005 . Accepted manuscript version, licensed CC BY-NC-ND 4.0. Increasing anthropogenic activities in the Arctic pose the risk for accidental oil spills but our knowledge of ecotoxicological effects...

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Bibliographic Details
Published in:Marine Environmental Research
Main Authors: Vieweg, Ireen, Benedetti, Maura, Lanzoni, Ilaria, Regoli, Francesco, Nahrgang, Jasmine
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2017
Subjects:
VDP::Matematikk og naturvitenskap: 400
VDP::Mathematics and natural scienses: 400
Økotoksikologi / Ecotoxicology
Fish
Arctic
Oil spills
Oxidative stress
Antioxidants
Biotransformation
Total oxyradical scavenging capacity
Boreogadus saida
polar cod
Online Access:https://hdl.handle.net/10037/13822
https://doi.org/10.1016/j.marenvres.2017.06.005
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Summary:Accepted manuscript version. Published version available at https://doi.org/10.1016/j.marenvres.2017.06.005 . Accepted manuscript version, licensed CC BY-NC-ND 4.0. Increasing anthropogenic activities in the Arctic pose the risk for accidental oil spills but our knowledge of ecotoxicological effects is still limited for Arctic organisms. This study aimed to provide insights in baseline levels of antioxidants in polar cod ( Boreogadus saida ) from different Arctic locations and investigate the susceptibility of this species to oxidative stress during a 32 day dietary crude oil exposure. Baseline levels of individual antioxidants and total oxyradical scavenging capacity (TOSC) varied among different Arctic fjords. Upon crude oil exposure, dose- and time-dependent polycyclic aromatic hydrocarbons (PAHs) biotransformation was evident through hepatic ethoxyresorufine-O-deethylase activity, glutathione S-transferase mRNA expression and biliary PAH metabolites. Changes in the activity of individual antioxidants and TOSC was, however, slight and transient upon exposure. In conclusion, biotransformation was clearly induced by the sub-lethal levels of crude oil in polar cod, while the antioxidant defense responded with high variability.

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