Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study
This is a pre-print of an article published in Osteoporosis International . The final authenticated version is available online at https://doi.org/10.1007/s00198-018-4653-z . Introduction: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteo...
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Online Access: | https://hdl.handle.net/10037/13593 https://doi.org/10.1007/s00198-018-4653-z |
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ftunivtroemsoe:oai:munin.uit.no:10037/13593 2023-05-15T18:34:31+02:00 Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine 2018-08-09 https://hdl.handle.net/10037/13593 https://doi.org/10.1007/s00198-018-4653-z eng eng Springer Verlag Osteoporosis International Hauger, A.V., Bergland, A., Holvik, K., Ståhle, A,, Emaus, N.& Strand, B.H. (2018). Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study. Osteoporosis International, 1-10. https://doi.org/10.1007/s00198-018-4653-z FRIDAID 1602122 doi:10.1007/s00198-018-4653-z 0937-941X 1433-2965 https://hdl.handle.net/10037/13593 openAccess VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Gripestyrke / Grip strength Osteopeni / Osteopenia Osteoporose / Osteoporosis Overlevelsesanalyse / Survival analysis Journal article Preprint Tidsskriftartikkel Manuskript 2018 ftunivtroemsoe https://doi.org/10.1007/s00198-018-4653-z 2021-06-25T17:56:03Z This is a pre-print of an article published in Osteoporosis International . The final authenticated version is available online at https://doi.org/10.1007/s00198-018-4653-z . Introduction: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier. Methods: The study population constituted 6565 participants aged 50–79 years at baseline in the Tromsø Study wave 4 conducted in 1994–1995. Forearm BMD measured by SXA was categorized as “normal,” “osteopenia,” or “osteoporosis” following WHO’s definition. Cox regression with all-cause mortality as the outcome over 22 years of follow-up was performed for men and women separately, adjusting for health-related factors, as well as BMD by grip strength interaction. A secondary analysis with a 15-year follow-up also adjusted for hip fractures and osteoporotic fractures. Results: During follow-up, 3176 of participants died (47%). Those categorized as osteoporotic had higher mortality hazard ratio (HR) compared to those with normal BMD; men HR = 1.37 (95% confidence interval (CI) 1.19, 1.58) and women HR = 1.32 (1.14, 1.53) were adjusted for age, body mass index, physical activity, smoking habits, education, health status, chronic diseases, and grip strength. Corresponding HRs for osteopenia were men HR = 1.13 (1.00, 1.27) and women HR = 1.17 (1.01, 1.35). Further adjustments for fractures did only marginally attenuate the results, and HRs were still significant. There was no grip strength by BMD interaction. Conclusion: Men and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Osteoporosis International 29 11 2447 2456 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Gripestyrke / Grip strength Osteopeni / Osteopenia Osteoporose / Osteoporosis Overlevelsesanalyse / Survival analysis |
spellingShingle |
VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Gripestyrke / Grip strength Osteopeni / Osteopenia Osteoporose / Osteoporosis Overlevelsesanalyse / Survival analysis Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
topic_facet |
VDP::Medisinske fag: 700 VDP::Midical sciences: 700 Gripestyrke / Grip strength Osteopeni / Osteopenia Osteoporose / Osteoporosis Overlevelsesanalyse / Survival analysis |
description |
This is a pre-print of an article published in Osteoporosis International . The final authenticated version is available online at https://doi.org/10.1007/s00198-018-4653-z . Introduction: To investigate if bone mineral density (BMD) levels of the distal forearm, consistent with osteopenia and osteoporosis, can predict mortality and if grip strength is an effect modifier. Methods: The study population constituted 6565 participants aged 50–79 years at baseline in the Tromsø Study wave 4 conducted in 1994–1995. Forearm BMD measured by SXA was categorized as “normal,” “osteopenia,” or “osteoporosis” following WHO’s definition. Cox regression with all-cause mortality as the outcome over 22 years of follow-up was performed for men and women separately, adjusting for health-related factors, as well as BMD by grip strength interaction. A secondary analysis with a 15-year follow-up also adjusted for hip fractures and osteoporotic fractures. Results: During follow-up, 3176 of participants died (47%). Those categorized as osteoporotic had higher mortality hazard ratio (HR) compared to those with normal BMD; men HR = 1.37 (95% confidence interval (CI) 1.19, 1.58) and women HR = 1.32 (1.14, 1.53) were adjusted for age, body mass index, physical activity, smoking habits, education, health status, chronic diseases, and grip strength. Corresponding HRs for osteopenia were men HR = 1.13 (1.00, 1.27) and women HR = 1.17 (1.01, 1.35). Further adjustments for fractures did only marginally attenuate the results, and HRs were still significant. There was no grip strength by BMD interaction. Conclusion: Men and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. |
format |
Article in Journal/Newspaper |
author |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine |
author_facet |
Hauger, Annette Vogt Bergland, Astrid Holvik, Kristin Ståhle, Agneta Emaus, Nina Strand, Bjørn Heine |
author_sort |
Hauger, Annette Vogt |
title |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_short |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_full |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_fullStr |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_full_unstemmed |
Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study |
title_sort |
osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based tromsø study |
publisher |
Springer Verlag |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/13593 https://doi.org/10.1007/s00198-018-4653-z |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Osteoporosis International Hauger, A.V., Bergland, A., Holvik, K., Ståhle, A,, Emaus, N.& Strand, B.H. (2018). Osteoporosis and osteopenia in the distal forearm predicts all-cause mortality independent of grip strength: 22-year follow-up in the population-based Tromsø Study. Osteoporosis International, 1-10. https://doi.org/10.1007/s00198-018-4653-z FRIDAID 1602122 doi:10.1007/s00198-018-4653-z 0937-941X 1433-2965 https://hdl.handle.net/10037/13593 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1007/s00198-018-4653-z |
container_title |
Osteoporosis International |
container_volume |
29 |
container_issue |
11 |
container_start_page |
2447 |
op_container_end_page |
2456 |
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1766219302887751680 |