Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum
Publisher's version allowed, licensed CC BY-NC-ND 4.0. Link to publisher's version: http://dx.doi.org/10.3390/molecules23061481 A new ecdysteroid, ponasterone F (1) and the previously reported compound ponasterone A (2) were isolated from specimens of the Arctic marine bryozoan Alcyonidium...
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Online Access: | https://hdl.handle.net/10037/13155 https://doi.org/10.3390/molecules23061481 |
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ftunivtroemsoe:oai:munin.uit.no:10037/13155 2023-05-15T14:25:20+02:00 Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum Østnes Hanssen, Kine Isaksson, Johan Glomsaker, Eirin Andersen, Jeanette hammer Hansen, Espen 2018-06-19 https://hdl.handle.net/10037/13155 https://doi.org/10.3390/molecules23061481 eng eng Multidisciplinary Digital Publishing Institute (MDPI) Molecules Universitetet i Tromsø: Publication grant Østnes Hanssen KØ, Isaksson JM, Glomsaker E, Andersen Jh, Hansen E. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018;23(6), 1481. http://dx.doi.org/10.3390/molecules23061481 FRIDAID 1592312 doi:10.3390/molecules23061481 1420-3049 https://hdl.handle.net/10037/13155 openAccess VDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 Journal article Tidsskriftartikkel Peer reviewed 2018 ftunivtroemsoe https://doi.org/10.3390/molecules23061481 2021-06-25T17:56:00Z Publisher's version allowed, licensed CC BY-NC-ND 4.0. Link to publisher's version: http://dx.doi.org/10.3390/molecules23061481 A new ecdysteroid, ponasterone F (1) and the previously reported compound ponasterone A (2) were isolated from specimens of the Arctic marine bryozoan Alcyonidium gelatinosum collected at Hopenbanken, off the coast of Edgeøya, Svalbard. The structure of 1 was elucidated, and the structure of 2 confirmed by spectroscopic methods including 1D and 2D NMR and analysis of HR-MS data. The compounds were evaluated for their ability to affect bacterial survival and cell viability, as well as their agonistic activities towards the estrogen receptors α and β. The compounds were not active in these assays. Compound 2 is an arthropod hormone controlling molting and are known to act as an allelochemical when produced by plants. Even though its structure has been previously reported, this is the first time a ponasterone has been isolated from a bryozoan. A. gelatinosum produced 1 and 2 in concentrations surpassing those expected of hormonal molecules, indicating their function as defence molecules against molting predators. This work adds to the chemical diversity reported from marine bryozoans and expanded our knowledge of the chemical modifications of the ponasterones Article in Journal/Newspaper Arctic Arctic Edgeøya Svalbard University of Tromsø: Munin Open Research Archive Arctic Edgeøya ENVELOPE(22.500,22.500,77.750,77.750) Svalbard Molecules 23 6 1481 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 |
spellingShingle |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 Østnes Hanssen, Kine Isaksson, Johan Glomsaker, Eirin Andersen, Jeanette hammer Hansen, Espen Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
topic_facet |
VDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497 VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497 |
description |
Publisher's version allowed, licensed CC BY-NC-ND 4.0. Link to publisher's version: http://dx.doi.org/10.3390/molecules23061481 A new ecdysteroid, ponasterone F (1) and the previously reported compound ponasterone A (2) were isolated from specimens of the Arctic marine bryozoan Alcyonidium gelatinosum collected at Hopenbanken, off the coast of Edgeøya, Svalbard. The structure of 1 was elucidated, and the structure of 2 confirmed by spectroscopic methods including 1D and 2D NMR and analysis of HR-MS data. The compounds were evaluated for their ability to affect bacterial survival and cell viability, as well as their agonistic activities towards the estrogen receptors α and β. The compounds were not active in these assays. Compound 2 is an arthropod hormone controlling molting and are known to act as an allelochemical when produced by plants. Even though its structure has been previously reported, this is the first time a ponasterone has been isolated from a bryozoan. A. gelatinosum produced 1 and 2 in concentrations surpassing those expected of hormonal molecules, indicating their function as defence molecules against molting predators. This work adds to the chemical diversity reported from marine bryozoans and expanded our knowledge of the chemical modifications of the ponasterones |
format |
Article in Journal/Newspaper |
author |
Østnes Hanssen, Kine Isaksson, Johan Glomsaker, Eirin Andersen, Jeanette hammer Hansen, Espen |
author_facet |
Østnes Hanssen, Kine Isaksson, Johan Glomsaker, Eirin Andersen, Jeanette hammer Hansen, Espen |
author_sort |
Østnes Hanssen, Kine |
title |
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
title_short |
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
title_full |
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
title_fullStr |
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
title_full_unstemmed |
Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum |
title_sort |
ponasterone a and f, ecdysteroids from the arctic bryozoan alcyonidium gelatinosum |
publisher |
Multidisciplinary Digital Publishing Institute (MDPI) |
publishDate |
2018 |
url |
https://hdl.handle.net/10037/13155 https://doi.org/10.3390/molecules23061481 |
long_lat |
ENVELOPE(22.500,22.500,77.750,77.750) |
geographic |
Arctic Edgeøya Svalbard |
geographic_facet |
Arctic Edgeøya Svalbard |
genre |
Arctic Arctic Edgeøya Svalbard |
genre_facet |
Arctic Arctic Edgeøya Svalbard |
op_relation |
Molecules Universitetet i Tromsø: Publication grant Østnes Hanssen KØ, Isaksson JM, Glomsaker E, Andersen Jh, Hansen E. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018;23(6), 1481. http://dx.doi.org/10.3390/molecules23061481 FRIDAID 1592312 doi:10.3390/molecules23061481 1420-3049 https://hdl.handle.net/10037/13155 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.3390/molecules23061481 |
container_title |
Molecules |
container_volume |
23 |
container_issue |
6 |
container_start_page |
1481 |
_version_ |
1766297752110628864 |