Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation?
Published version available in http://doi.org/10.4103/cytojournal.cytojournal_34_16 . Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples betwe...
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ftunivtroemsoe:oai:munin.uit.no:10037/12473 2023-05-15T17:39:25+02:00 Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? Sørbye, Sveinung Pedersen, Mette Kristin Ekeberg, Bente Wiliams, Merete E. Johansen Sauer, Torill Chen, Ying 2017-08-22 https://hdl.handle.net/10037/12473 eng eng Medknow Publications CytoJournal Sørbye, S. W., Pedersen, M. K., Ekeberg, B., Williams, M. E., Sauer, T., Chen, Y. (2017). Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation?. CytoJournal 14:20 FRIDAID 1518709 10.4103/cytojournal. cytojournal_34_16 1742-6413 https://hdl.handle.net/10037/12473 openAccess Background cervical cytology inadequate SurePath ThinPrep unsatisfactory VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 Journal article Tidsskriftartikkel Peer reviewed 2017 ftunivtroemsoe 2021-06-25T17:55:39Z Published version available in http://doi.org/10.4103/cytojournal.cytojournal_34_16 . Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath protocol. Materials and Methods: A total of 187 inadequate ThinPrep specimens from the Department of Clinical Pathology at University Hospital of North Norway were sent to Akershus University Hospital for conversion to SurePath medium. Ninety-one (48.7%) were processed through the automated “gynecologic” application for cervix cytology samples, and 96 (51.3%) were processed with the “nongynecological” automatic program. Results: Out of 187 samples that had been unsatisfactory by ThinPrep, 93 (49.7%) were satisfactory after being converted to SurePath. The rate of satisfactory cytology was 36.6% and 62.5% for samples run through the “gynecology” program and “nongynecology” program, respectively. Of the 93 samples that became satisfactory after conversion from ThinPrep to SurePath, 80 (86.0%) were screened as normal while 13 samples (14.0%) were given an abnormal diagnosis, which included 5 atypical squamous cells of undetermined significance, 5 low-grade squamous intraepithelial lesion, 2 atypical glandular cells not otherwise specified, and 1 atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion. A total of 2.1% (4/187) of the women got a diagnosis of cervical intraepithelial neoplasia 2 or higher at a later follow-up. Conclusions: Converting cytology samples from ThinPrep to SurePath processing can reduce the number of unsatisfactory samples. The samples should be run through the “nongynecology” program to ensure an adequate number of cells. Article in Journal/Newspaper North Norway University of Tromsø: Munin Open Research Archive Norway |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Background cervical cytology inadequate SurePath ThinPrep unsatisfactory VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 |
spellingShingle |
Background cervical cytology inadequate SurePath ThinPrep unsatisfactory VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 Sørbye, Sveinung Pedersen, Mette Kristin Ekeberg, Bente Wiliams, Merete E. Johansen Sauer, Torill Chen, Ying Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
topic_facet |
Background cervical cytology inadequate SurePath ThinPrep unsatisfactory VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 |
description |
Published version available in http://doi.org/10.4103/cytojournal.cytojournal_34_16 . Background: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath protocol. Materials and Methods: A total of 187 inadequate ThinPrep specimens from the Department of Clinical Pathology at University Hospital of North Norway were sent to Akershus University Hospital for conversion to SurePath medium. Ninety-one (48.7%) were processed through the automated “gynecologic” application for cervix cytology samples, and 96 (51.3%) were processed with the “nongynecological” automatic program. Results: Out of 187 samples that had been unsatisfactory by ThinPrep, 93 (49.7%) were satisfactory after being converted to SurePath. The rate of satisfactory cytology was 36.6% and 62.5% for samples run through the “gynecology” program and “nongynecology” program, respectively. Of the 93 samples that became satisfactory after conversion from ThinPrep to SurePath, 80 (86.0%) were screened as normal while 13 samples (14.0%) were given an abnormal diagnosis, which included 5 atypical squamous cells of undetermined significance, 5 low-grade squamous intraepithelial lesion, 2 atypical glandular cells not otherwise specified, and 1 atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion. A total of 2.1% (4/187) of the women got a diagnosis of cervical intraepithelial neoplasia 2 or higher at a later follow-up. Conclusions: Converting cytology samples from ThinPrep to SurePath processing can reduce the number of unsatisfactory samples. The samples should be run through the “nongynecology” program to ensure an adequate number of cells. |
format |
Article in Journal/Newspaper |
author |
Sørbye, Sveinung Pedersen, Mette Kristin Ekeberg, Bente Wiliams, Merete E. Johansen Sauer, Torill Chen, Ying |
author_facet |
Sørbye, Sveinung Pedersen, Mette Kristin Ekeberg, Bente Wiliams, Merete E. Johansen Sauer, Torill Chen, Ying |
author_sort |
Sørbye, Sveinung |
title |
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
title_short |
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
title_full |
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
title_fullStr |
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
title_full_unstemmed |
Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation? |
title_sort |
can an inadequate cervical cytology sample in thinprep be converted to a satisfactory sample by processing it with a surepath preparation? |
publisher |
Medknow Publications |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/12473 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
North Norway |
genre_facet |
North Norway |
op_relation |
CytoJournal Sørbye, S. W., Pedersen, M. K., Ekeberg, B., Williams, M. E., Sauer, T., Chen, Y. (2017). Can an inadequate cervical cytology sample in ThinPrep be converted to a satisfactory sample by processing it with a SurePath preparation?. CytoJournal 14:20 FRIDAID 1518709 10.4103/cytojournal. cytojournal_34_16 1742-6413 https://hdl.handle.net/10037/12473 |
op_rights |
openAccess |
_version_ |
1766140185606619136 |