Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study
Introduction: Osteoporosis is characterized by decreased bone mineral density (BMD) and is a risk factor for hip, wrist, and vertebral fractures. Fragility fractures lead to increased mortality, morbidity, pain, immobility, social isolation and depression, which all may affect the quality of life (Q...
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ftunivtroemsoe:oai:munin.uit.no:10037/12337 2023-05-15T18:34:17+02:00 Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study Fouad, Mahmood 2017-05-15 https://hdl.handle.net/10037/12337 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/12337 openAccess Copyright 2017 The Author(s) VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsfarmasi: 812 VDP::Medical disciplines: 700::Health sciences: 800::Community pharmacy: 812 VDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829 VDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829 FAR-3911 Master thesis Mastergradsoppgave 2017 ftunivtroemsoe 2021-06-25T17:55:51Z Introduction: Osteoporosis is characterized by decreased bone mineral density (BMD) and is a risk factor for hip, wrist, and vertebral fractures. Fragility fractures lead to increased mortality, morbidity, pain, immobility, social isolation and depression, which all may affect the quality of life (QoL). Use of anti-osteoporotic drugs (AOD) reduces the risk of fractures and may influence QoL. Objective: To investigate a potential association between AOD use and QoL among women and men with osteoporosis. Methods: This is a cross-sectional study of The Tromsø Study (Tromsø 6). The 12984 study participants were inhabitants in Tromsø aged ≥ 50 years who had osteoporosis, defined by T-score for BMD <-2.5 or from -2.5 to -1.6 combined with prior fracture (n=544). In multivariable linear regression analysis, QoL scores (EQ-5D 3L) was the dependent variable, AOD was independent variable, and adjusted for the covariates age, sex, height, weight, education prior fracture and other diseases. Results: The mean QoL score was 0.68 (SD=0.28) in 54 participants using AOD and 0.82 (SD=0.18) in 424 participants not using AOD. The QoL was inversely associated with use of AOD (B=-0.116, p=0.002) after adjusting for covariates. Conclusion: Persons with osteoporosis who were using AOD had significantly lower QoL compared to the AOD non-users. Confounding by severity or awareness of disease could be a problem, as not all participants knew they had osteoporosis. Master Thesis Tromsø University of Tromsø: Munin Open Research Archive Tromsø |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsfarmasi: 812 VDP::Medical disciplines: 700::Health sciences: 800::Community pharmacy: 812 VDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829 VDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829 FAR-3911 |
spellingShingle |
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsfarmasi: 812 VDP::Medical disciplines: 700::Health sciences: 800::Community pharmacy: 812 VDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829 VDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829 FAR-3911 Fouad, Mahmood Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsfarmasi: 812 VDP::Medical disciplines: 700::Health sciences: 800::Community pharmacy: 812 VDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829 VDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829 FAR-3911 |
description |
Introduction: Osteoporosis is characterized by decreased bone mineral density (BMD) and is a risk factor for hip, wrist, and vertebral fractures. Fragility fractures lead to increased mortality, morbidity, pain, immobility, social isolation and depression, which all may affect the quality of life (QoL). Use of anti-osteoporotic drugs (AOD) reduces the risk of fractures and may influence QoL. Objective: To investigate a potential association between AOD use and QoL among women and men with osteoporosis. Methods: This is a cross-sectional study of The Tromsø Study (Tromsø 6). The 12984 study participants were inhabitants in Tromsø aged ≥ 50 years who had osteoporosis, defined by T-score for BMD <-2.5 or from -2.5 to -1.6 combined with prior fracture (n=544). In multivariable linear regression analysis, QoL scores (EQ-5D 3L) was the dependent variable, AOD was independent variable, and adjusted for the covariates age, sex, height, weight, education prior fracture and other diseases. Results: The mean QoL score was 0.68 (SD=0.28) in 54 participants using AOD and 0.82 (SD=0.18) in 424 participants not using AOD. The QoL was inversely associated with use of AOD (B=-0.116, p=0.002) after adjusting for covariates. Conclusion: Persons with osteoporosis who were using AOD had significantly lower QoL compared to the AOD non-users. Confounding by severity or awareness of disease could be a problem, as not all participants knew they had osteoporosis. |
format |
Master Thesis |
author |
Fouad, Mahmood |
author_facet |
Fouad, Mahmood |
author_sort |
Fouad, Mahmood |
title |
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
title_short |
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
title_full |
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
title_fullStr |
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
title_full_unstemmed |
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study |
title_sort |
anti-osteoporotic drug use and quality of life in persons with osteoporosis – the tromsø study |
publisher |
UiT Norges arktiske universitet |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/12337 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://hdl.handle.net/10037/12337 |
op_rights |
openAccess Copyright 2017 The Author(s) |
_version_ |
1766218972824338432 |