Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study
Source at http://doi.org/10.1371/journal.pone.0173045 Background: Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associ...
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Online Access: | https://hdl.handle.net/10037/12164 https://doi.org/10.1371/journal.pone.0173045 |
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ftunivtroemsoe:oai:munin.uit.no:10037/12164 2023-05-15T17:43:41+02:00 Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study Martinaityte, Ieva Jorde, Rolf Emaus, Nina Eggen, Anne Elise Joakimsen, Ragnar Martin Kamycheva, Elena 2017-03-02 https://hdl.handle.net/10037/12164 https://doi.org/10.1371/journal.pone.0173045 eng eng Public Library of Science PLoS ONE Martinaityte, I., Jorde, R., Emaus, N., Eggen, A.E., Joakimsen, R.M., Kamycheva, E. Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study. PLoS ONE. 2017;12:e0173045(3):1-12 FRIDAID 1488393 doi:10.1371/journal.pone.0173045 1932-6203 https://hdl.handle.net/10037/12164 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 Journal article Tidsskriftartikkel Peer reviewed 2017 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0173045 2021-06-25T17:55:41Z Source at http://doi.org/10.1371/journal.pone.0173045 Background: Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associated with vitamin D receptor (VDR), serum 25(OH)D levels and estrogen receptor 1 (ESR1), but without consensus. Therefore, we aimed to map and compare the risk genotypes for forearm and total hip low BMD. Methods and findings: Data were derived from a population-based study in northern Norway; the Tromsø Study. Distal forearm BMD was measured with a single x-ray absorptiometric device, while total hip BMD was measured with a dual-energy x-ray absorptiometric device. There were 7,317 and 4,082 successful analyses of distal forearm and total hip BMD, respectively, and at least one SNP of interest. We evaluated plausible BMD modulating factors and associations of BMD and SNPs related to vitamin D metabolism (FokI, Cdx2, BsmI, rs2298850, rs10741657, rs3794060, rs6013897), ApaI-BsmI-TaqI haplotypes and ESR1 SNP rs4870044. Results: Age, BMI, physical activity and smoking were significantly associated with BMD. In a linear regression model with adjustment for age and gender and with the major homozygote as reference, rs6013897 had a standardized beta coefficient (β) of –0.031 (P = 0.024) for total hip BMD. β for ESR1 SNP rs4870044 was –0.016 (P = 0.036) for forearm BMD and –0.034 (P = 0.015) for total hip BMD. The other SNPs nor serum 25(OH)D were significantly associated with BMD. Conclusions: Both forearm and total hip BMD were associated with ESR1 SNP rs4870044. Of the vitamin D–related genes, only CYP24A1 gene rs6013897 was associated with total hip BMD, but the association was weak and needs confirmation in other studies. Serum 25(OH)D was not associated with BMD in our population, probably due to the generally sufficient vitamin D levels in the population. Article in Journal/Newspaper Northern Norway Tromsø University of Tromsø: Munin Open Research Archive Norway Tromsø PLOS ONE 12 3 e0173045 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 Martinaityte, Ieva Jorde, Rolf Emaus, Nina Eggen, Anne Elise Joakimsen, Ragnar Martin Kamycheva, Elena Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774 |
description |
Source at http://doi.org/10.1371/journal.pone.0173045 Background: Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associated with vitamin D receptor (VDR), serum 25(OH)D levels and estrogen receptor 1 (ESR1), but without consensus. Therefore, we aimed to map and compare the risk genotypes for forearm and total hip low BMD. Methods and findings: Data were derived from a population-based study in northern Norway; the Tromsø Study. Distal forearm BMD was measured with a single x-ray absorptiometric device, while total hip BMD was measured with a dual-energy x-ray absorptiometric device. There were 7,317 and 4,082 successful analyses of distal forearm and total hip BMD, respectively, and at least one SNP of interest. We evaluated plausible BMD modulating factors and associations of BMD and SNPs related to vitamin D metabolism (FokI, Cdx2, BsmI, rs2298850, rs10741657, rs3794060, rs6013897), ApaI-BsmI-TaqI haplotypes and ESR1 SNP rs4870044. Results: Age, BMI, physical activity and smoking were significantly associated with BMD. In a linear regression model with adjustment for age and gender and with the major homozygote as reference, rs6013897 had a standardized beta coefficient (β) of –0.031 (P = 0.024) for total hip BMD. β for ESR1 SNP rs4870044 was –0.016 (P = 0.036) for forearm BMD and –0.034 (P = 0.015) for total hip BMD. The other SNPs nor serum 25(OH)D were significantly associated with BMD. Conclusions: Both forearm and total hip BMD were associated with ESR1 SNP rs4870044. Of the vitamin D–related genes, only CYP24A1 gene rs6013897 was associated with total hip BMD, but the association was weak and needs confirmation in other studies. Serum 25(OH)D was not associated with BMD in our population, probably due to the generally sufficient vitamin D levels in the population. |
format |
Article in Journal/Newspaper |
author |
Martinaityte, Ieva Jorde, Rolf Emaus, Nina Eggen, Anne Elise Joakimsen, Ragnar Martin Kamycheva, Elena |
author_facet |
Martinaityte, Ieva Jorde, Rolf Emaus, Nina Eggen, Anne Elise Joakimsen, Ragnar Martin Kamycheva, Elena |
author_sort |
Martinaityte, Ieva |
title |
Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
title_short |
Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
title_full |
Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
title_fullStr |
Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
title_full_unstemmed |
Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study |
title_sort |
bone mineral density is associated with vitamin d related rs6013897 and estrogen receptor polymorphism rs4870044: the tromsø study |
publisher |
Public Library of Science |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/12164 https://doi.org/10.1371/journal.pone.0173045 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_relation |
PLoS ONE Martinaityte, I., Jorde, R., Emaus, N., Eggen, A.E., Joakimsen, R.M., Kamycheva, E. Bone mineral density is associated with Vitamin D related rs6013897 and estrogen receptor polymorphism rs4870044: The Tromsø study. PLoS ONE. 2017;12:e0173045(3):1-12 FRIDAID 1488393 doi:10.1371/journal.pone.0173045 1932-6203 https://hdl.handle.net/10037/12164 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0173045 |
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PLOS ONE |
container_volume |
12 |
container_issue |
3 |
container_start_page |
e0173045 |
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