The association between whole blood mercury and the risk of developing CVD among the Greenlandic population
Introduction: The World Health Organization, estimated that 17.5 million people died from cardiovascular disease (CVD) in 2012 alone, accounting for 30% of global deaths and serving as the number one cause of death globally. Environmental pollutants, such as heavy metals (e.g. mercury) and persisten...
Main Author: | |
---|---|
Format: | Master Thesis |
Language: | English |
Published: |
UiT Norges arktiske universitet
2017
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/11339 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/11339 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/11339 2023-05-15T15:18:01+02:00 The association between whole blood mercury and the risk of developing CVD among the Greenlandic population Larsen, Trine Louise Jul 2017-05-15 https://hdl.handle.net/10037/11339 eng eng UiT Norges arktiske universitet UiT The Arctic University of Norway https://hdl.handle.net/10037/11339 openAccess Copyright 2017 The Author(s) Public Health VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 HEL-3950 Master thesis Mastergradsoppgave 2017 ftunivtroemsoe 2021-06-25T17:55:22Z Introduction: The World Health Organization, estimated that 17.5 million people died from cardiovascular disease (CVD) in 2012 alone, accounting for 30% of global deaths and serving as the number one cause of death globally. Environmental pollutants, such as heavy metals (e.g. mercury) and persistent organic pollutants (POPs) (e.g. polychlorinated biphenyl (PCBs), may contribute to the burden of CVD, especially within the Arctic. The highest levels of whole blood mercury have been found in Greenland. Objective: To explore the association between whole blood mercury and the risk of developing CVD among the Greenlandic population. Methods: The continuous effects of whole blood mercury levels of incident CVD were investigated, among 3083 participants, from the population-based cohort study ‘Inuit Health in Transition Greenland survey 2005-2010’ using cox regression. Both univariate and multivariate analyses were conducted, adjusting for a range of potential confounders. Whole blood mercury was measured at inclusion. Participants were followed in the National Patient registries for Denmark and Greenland and in the cause of death register for CVD events. The overall incidence rates and the hazard ratio of CVD events among participants for overall CVD were calculated. Potential interactions with sex were also investigated. Results: The highest levels of whole blood mercury were found in men, who had a significantly higher median level of 19 μg/L, compared with women (15 μg/L (p<0.001)). The crude hazard ratio (HR) for developing overall CVD was 0.99 (95% CI 0.99-1.00) for any given level of whole blood mercury. After adjusting for several potential confounders, the HR remained 0.99 (95% CI 0.98-1.00). Conclusion: The present study found no association between whole blood mercury and the risk of developing CVD among the Greenlandic population. Furture research on mercury should investigate genetic susceptibility of mercury among the Greenlandic population, as susceptibility to mercury, may be increased by genetic factors. Master Thesis Arctic Greenland greenlandic inuit University of Tromsø: Munin Open Research Archive Arctic Greenland |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Public Health VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 HEL-3950 |
spellingShingle |
Public Health VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 HEL-3950 Larsen, Trine Louise Jul The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
topic_facet |
Public Health VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 HEL-3950 |
description |
Introduction: The World Health Organization, estimated that 17.5 million people died from cardiovascular disease (CVD) in 2012 alone, accounting for 30% of global deaths and serving as the number one cause of death globally. Environmental pollutants, such as heavy metals (e.g. mercury) and persistent organic pollutants (POPs) (e.g. polychlorinated biphenyl (PCBs), may contribute to the burden of CVD, especially within the Arctic. The highest levels of whole blood mercury have been found in Greenland. Objective: To explore the association between whole blood mercury and the risk of developing CVD among the Greenlandic population. Methods: The continuous effects of whole blood mercury levels of incident CVD were investigated, among 3083 participants, from the population-based cohort study ‘Inuit Health in Transition Greenland survey 2005-2010’ using cox regression. Both univariate and multivariate analyses were conducted, adjusting for a range of potential confounders. Whole blood mercury was measured at inclusion. Participants were followed in the National Patient registries for Denmark and Greenland and in the cause of death register for CVD events. The overall incidence rates and the hazard ratio of CVD events among participants for overall CVD were calculated. Potential interactions with sex were also investigated. Results: The highest levels of whole blood mercury were found in men, who had a significantly higher median level of 19 μg/L, compared with women (15 μg/L (p<0.001)). The crude hazard ratio (HR) for developing overall CVD was 0.99 (95% CI 0.99-1.00) for any given level of whole blood mercury. After adjusting for several potential confounders, the HR remained 0.99 (95% CI 0.98-1.00). Conclusion: The present study found no association between whole blood mercury and the risk of developing CVD among the Greenlandic population. Furture research on mercury should investigate genetic susceptibility of mercury among the Greenlandic population, as susceptibility to mercury, may be increased by genetic factors. |
format |
Master Thesis |
author |
Larsen, Trine Louise Jul |
author_facet |
Larsen, Trine Louise Jul |
author_sort |
Larsen, Trine Louise Jul |
title |
The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
title_short |
The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
title_full |
The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
title_fullStr |
The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
title_full_unstemmed |
The association between whole blood mercury and the risk of developing CVD among the Greenlandic population |
title_sort |
association between whole blood mercury and the risk of developing cvd among the greenlandic population |
publisher |
UiT Norges arktiske universitet |
publishDate |
2017 |
url |
https://hdl.handle.net/10037/11339 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland greenlandic inuit |
genre_facet |
Arctic Greenland greenlandic inuit |
op_relation |
https://hdl.handle.net/10037/11339 |
op_rights |
openAccess Copyright 2017 The Author(s) |
_version_ |
1766348249312002048 |