Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions
Published version. Source at http://doi.org/10.1038/srep25211 . License CC BY 4.0 . Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern re...
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ftunivtroemsoe:oai:munin.uit.no:10037/10746 2023-05-15T15:26:20+02:00 Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions Solbakken, Monica Hongrø Tørresen, Ole Kristian Nederbragt, Alexander Johan Seppola, Marit Gregers, Tone Fredsvik Jakobsen, Kjetill Sigurd Jentoft, Sissel 2016 https://hdl.handle.net/10037/10746 https://doi.org/10.1038/srep25211 eng eng Springer Nature Scientific Reports info:eu-repo/grantAgreement/RCN/FundingProgram/179569/Norway/// info:eu-repo/grantAgreement/RCN/FundingProgram/222378/Norway/// info:eu-repo/grantAgreement/RCN/FundingProgram/199806/Norway/// Solbakken et al. Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions. Scientific Reports. 2016;6 FRIDAID 1353484 doi:10.1038/srep25211 2045-2322 https://hdl.handle.net/10037/10746 openAccess VDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1038/srep25211 2021-06-25T17:55:06Z Published version. Source at http://doi.org/10.1038/srep25211 . License CC BY 4.0 . Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition receptor (PRR) family of Toll-like receptors (TLR). In a comparative genomic setting, using an improved version of the genome, we characterize PRRs in Atlantic cod with emphasis on TLRs demonstrating the loss of TLR1/6, TLR2 and TLR5 and expansion of TLR7, TLR8, TLR9, TLR22 and TLR25. We find that Atlantic cod TLR expansions are strongly influenced by diversifying selection likely to increase the detectable ligand repertoire through neo- and subfunctionalization. Using RNAseq we find that Atlantic cod TLRs display likely tissue or developmental stage-specific expression patterns. In a broader perspective, a comprehensive vertebrate TLR phylogeny reveals that the Atlantic cod TLR repertoire is extreme with regards to losses and expansions compared to other teleosts. In addition we identify a substantial shift in TLR repertoires following the evolutionary transition from an aquatic vertebrate (fish) to a terrestrial (tetrapod) life style. Collectively, our findings provide new insight into the function and evolution of TLRs in Atlantic cod as well as the evolutionary history of vertebrate innate immunity. Article in Journal/Newspaper atlantic cod Gadus morhua University of Tromsø: Munin Open Research Archive Scientific Reports 6 1 |
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University of Tromsø: Munin Open Research Archive |
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ftunivtroemsoe |
language |
English |
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VDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474 |
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VDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474 Solbakken, Monica Hongrø Tørresen, Ole Kristian Nederbragt, Alexander Johan Seppola, Marit Gregers, Tone Fredsvik Jakobsen, Kjetill Sigurd Jentoft, Sissel Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
topic_facet |
VDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474 |
description |
Published version. Source at http://doi.org/10.1038/srep25211 . License CC BY 4.0 . Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class I and gene expansions and losses in the innate pattern recognition receptor (PRR) family of Toll-like receptors (TLR). In a comparative genomic setting, using an improved version of the genome, we characterize PRRs in Atlantic cod with emphasis on TLRs demonstrating the loss of TLR1/6, TLR2 and TLR5 and expansion of TLR7, TLR8, TLR9, TLR22 and TLR25. We find that Atlantic cod TLR expansions are strongly influenced by diversifying selection likely to increase the detectable ligand repertoire through neo- and subfunctionalization. Using RNAseq we find that Atlantic cod TLRs display likely tissue or developmental stage-specific expression patterns. In a broader perspective, a comprehensive vertebrate TLR phylogeny reveals that the Atlantic cod TLR repertoire is extreme with regards to losses and expansions compared to other teleosts. In addition we identify a substantial shift in TLR repertoires following the evolutionary transition from an aquatic vertebrate (fish) to a terrestrial (tetrapod) life style. Collectively, our findings provide new insight into the function and evolution of TLRs in Atlantic cod as well as the evolutionary history of vertebrate innate immunity. |
format |
Article in Journal/Newspaper |
author |
Solbakken, Monica Hongrø Tørresen, Ole Kristian Nederbragt, Alexander Johan Seppola, Marit Gregers, Tone Fredsvik Jakobsen, Kjetill Sigurd Jentoft, Sissel |
author_facet |
Solbakken, Monica Hongrø Tørresen, Ole Kristian Nederbragt, Alexander Johan Seppola, Marit Gregers, Tone Fredsvik Jakobsen, Kjetill Sigurd Jentoft, Sissel |
author_sort |
Solbakken, Monica Hongrø |
title |
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
title_short |
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
title_full |
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
title_fullStr |
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
title_full_unstemmed |
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions |
title_sort |
evolutionary redesign of the atlantic cod (gadus morhua l.) toll-like receptor repertoire by gene losses and expansions |
publisher |
Springer Nature |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10746 https://doi.org/10.1038/srep25211 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
Scientific Reports info:eu-repo/grantAgreement/RCN/FundingProgram/179569/Norway/// info:eu-repo/grantAgreement/RCN/FundingProgram/222378/Norway/// info:eu-repo/grantAgreement/RCN/FundingProgram/199806/Norway/// Solbakken et al. Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions. Scientific Reports. 2016;6 FRIDAID 1353484 doi:10.1038/srep25211 2045-2322 https://hdl.handle.net/10037/10746 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1038/srep25211 |
container_title |
Scientific Reports |
container_volume |
6 |
container_issue |
1 |
_version_ |
1766356831542706176 |