Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study
Accepted manuscript version. Source at http://dx.doi.org/10.1111/bdi.12389 Objective: Previous studies from North Norway showed significantly increased mortality in patients with schizophrenia and personality disorder. The aim of the present study was to investigate total and cause- specific mortality...
Published in: | Bipolar Disorders |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
John Wiley & Sons Ltd.
2016
|
Subjects: | |
Online Access: | https://hdl.handle.net/10037/10714 https://doi.org/10.1111/bdi.12389 |
id |
ftunivtroemsoe:oai:munin.uit.no:10037/10714 |
---|---|
record_format |
openpolar |
spelling |
ftunivtroemsoe:oai:munin.uit.no:10037/10714 2023-05-15T17:39:21+02:00 Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study Høye, Anne Nesvåg, Ragnar Reichborn-Kjennerud, Ted Jacobsen, Bjarne K. 2016-05-26 https://hdl.handle.net/10037/10714 https://doi.org/10.1111/bdi.12389 eng eng John Wiley & Sons Ltd. Bipolar Disorders Høye A., Nesvåg R., Reichborn-Kjennerud T., Jacobsen B. K. Sex differences in mortality among patients admitted with affective disorders in North Norway: a 33-year prospective register study. Bipolar Disord 2016: 18: 272–281. FRIDAID 1363518 doi:10.1111/bdi.12389 1398-5647 1399-5618 https://hdl.handle.net/10037/10714 openAccess affective disorders sex differences mortality VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1111/bdi.12389 2021-06-25T17:55:08Z Accepted manuscript version. Source at http://dx.doi.org/10.1111/bdi.12389 Objective: Previous studies from North Norway showed significantly increased mortality in patients with schizophrenia and personality disorder. The aim of the present study was to investigate total and cause- specific mortality in inpatients with affective disorder in a 33-year follow- up cohort, with a specific focus on sex differences. Methods: Based on a hospital case register covering all admissions to psychiatric hospital in the two northernmost counties in Norway from 1980 to 2012, 790 men and 866 women with major depressive disorder and 331 men and 514 women with bipolar disorder were included. The cohort was linked to the Norwegian Cause of Death Registry. The relative mortality in men compared to women was tested using Cox regression with attained age as the time variable. The standardized mortality ratio (SMR) of the patients when compared to the general population in Norway was calculated. Results: Patients with affective disorders had twice the mortality of the general Norwegian population [SMR = 2.1, 95% confidence interval (CI): 1.9–2.3]. For major depressive disorder, the SMR for total mortality was higher among men (2.6, 95% CI: 2.2–3.0) than women (1.8, 95% CI: 1.5–2.1). For bipolar disorder, no difference was seen between men and women. The SMR for suicide among women showed an increasing trend throughout the period 1980–1990: 20.0 (95% CI: 10.4–38.4); 1991–2001: 27.0 (95% CI: 15.7–46.2); 2002–2012: 40.4 (95% CI: 23.0–71.2). Conclusions: The substantially increased mortality in patients with affective disorders in Norway has been persistent over a period of 33 years, despite extensive reforms in psychiatric health care. Indications of increasing SMR for suicide in women call for further research. Article in Journal/Newspaper North Norway University of Tromsø: Munin Open Research Archive Norway Bipolar Disorders 18 3 272 281 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
affective disorders sex differences mortality VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 |
spellingShingle |
affective disorders sex differences mortality VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 Høye, Anne Nesvåg, Ragnar Reichborn-Kjennerud, Ted Jacobsen, Bjarne K. Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
topic_facet |
affective disorders sex differences mortality VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 |
description |
Accepted manuscript version. Source at http://dx.doi.org/10.1111/bdi.12389 Objective: Previous studies from North Norway showed significantly increased mortality in patients with schizophrenia and personality disorder. The aim of the present study was to investigate total and cause- specific mortality in inpatients with affective disorder in a 33-year follow- up cohort, with a specific focus on sex differences. Methods: Based on a hospital case register covering all admissions to psychiatric hospital in the two northernmost counties in Norway from 1980 to 2012, 790 men and 866 women with major depressive disorder and 331 men and 514 women with bipolar disorder were included. The cohort was linked to the Norwegian Cause of Death Registry. The relative mortality in men compared to women was tested using Cox regression with attained age as the time variable. The standardized mortality ratio (SMR) of the patients when compared to the general population in Norway was calculated. Results: Patients with affective disorders had twice the mortality of the general Norwegian population [SMR = 2.1, 95% confidence interval (CI): 1.9–2.3]. For major depressive disorder, the SMR for total mortality was higher among men (2.6, 95% CI: 2.2–3.0) than women (1.8, 95% CI: 1.5–2.1). For bipolar disorder, no difference was seen between men and women. The SMR for suicide among women showed an increasing trend throughout the period 1980–1990: 20.0 (95% CI: 10.4–38.4); 1991–2001: 27.0 (95% CI: 15.7–46.2); 2002–2012: 40.4 (95% CI: 23.0–71.2). Conclusions: The substantially increased mortality in patients with affective disorders in Norway has been persistent over a period of 33 years, despite extensive reforms in psychiatric health care. Indications of increasing SMR for suicide in women call for further research. |
format |
Article in Journal/Newspaper |
author |
Høye, Anne Nesvåg, Ragnar Reichborn-Kjennerud, Ted Jacobsen, Bjarne K. |
author_facet |
Høye, Anne Nesvåg, Ragnar Reichborn-Kjennerud, Ted Jacobsen, Bjarne K. |
author_sort |
Høye, Anne |
title |
Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
title_short |
Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
title_full |
Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
title_fullStr |
Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
title_full_unstemmed |
Sex differences in mortality among patients admitted with affective disorders in North Norway: A 33-year prospective register study |
title_sort |
sex differences in mortality among patients admitted with affective disorders in north norway: a 33-year prospective register study |
publisher |
John Wiley & Sons Ltd. |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10714 https://doi.org/10.1111/bdi.12389 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
North Norway |
genre_facet |
North Norway |
op_relation |
Bipolar Disorders Høye A., Nesvåg R., Reichborn-Kjennerud T., Jacobsen B. K. Sex differences in mortality among patients admitted with affective disorders in North Norway: a 33-year prospective register study. Bipolar Disord 2016: 18: 272–281. FRIDAID 1363518 doi:10.1111/bdi.12389 1398-5647 1399-5618 https://hdl.handle.net/10037/10714 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1111/bdi.12389 |
container_title |
Bipolar Disorders |
container_volume |
18 |
container_issue |
3 |
container_start_page |
272 |
op_container_end_page |
281 |
_version_ |
1766140112855367680 |