Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08)
Published version. Source at http://dx.doi.org/10.1111/aos.13337 Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, wi...
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Online Access: | https://hdl.handle.net/10037/10476 https://doi.org/10.1111/aos.13337 |
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ftunivtroemsoe:oai:munin.uit.no:10037/10476 2023-05-15T18:34:54+02:00 Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) Hanno, Therese von Lade, Anette Caroline Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir 2016-12-18 https://hdl.handle.net/10037/10476 https://doi.org/10.1111/aos.13337 eng eng Wiley Acta Ophthalmologica Hanno T, Lade AC, Mathiesen EB, Peto T, Njølstad i, Bertelsen G. Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08). Acta Ophthalmologica. 2016 FRIDAID 1419972 doi:10.1111/aos.13337 1755-375X 1755-3768 https://hdl.handle.net/10037/10476 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754 age epidemiology optical coherence tomography population based refraction retina sex Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1111/aos.13337 2021-06-25T17:55:06Z Published version. Source at http://dx.doi.org/10.1111/aos.13337 Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence tomography (spectral domain Cirrus HD-OCT). Results: Women had thinner retina than men. Retinal thickness was significantly associated with refraction, where mean change in retinal thickness per 1Dincrease in SER was 1.3 (0.2) lm in the fovea, 0.7 (0.1) lm in the pericentral ring and 1.4 (0.1) lm in the peripheral ring. In the fovea, there was a non-monotonic curved relationship between retinal thickness and age in both sexes with a maximum at about 60 years (p < 0.001). In the pericentral ring, the mean reduction in retinal thickness per 10-year increase was 2.7 (0.3) lm in women and 4.0 (0.4) lm in men and corresponding results in the peripheral ring were 2.3 (0.3) lmin women and 2.6 (0.4) lmin men. In both regions, there was evidence for a nonlinear pattern with an increased rate of change with higher age. There was a significant interaction between sex and age for retinal thickness of the pericentral ring (p = 0.041). Conclusion: Women had thinner retina than men, and thickness varied with refractive status. Retinal thickness was associated with age in all macular regions, and the rate of change in retinal thickness varied at different ages. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Acta Ophthalmologica 95 3 262 269 |
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Open Polar |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754 age epidemiology optical coherence tomography population based refraction retina sex |
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VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754 age epidemiology optical coherence tomography population based refraction retina sex Hanno, Therese von Lade, Anette Caroline Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754 age epidemiology optical coherence tomography population based refraction retina sex |
description |
Published version. Source at http://dx.doi.org/10.1111/aos.13337 Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence tomography (spectral domain Cirrus HD-OCT). Results: Women had thinner retina than men. Retinal thickness was significantly associated with refraction, where mean change in retinal thickness per 1Dincrease in SER was 1.3 (0.2) lm in the fovea, 0.7 (0.1) lm in the pericentral ring and 1.4 (0.1) lm in the peripheral ring. In the fovea, there was a non-monotonic curved relationship between retinal thickness and age in both sexes with a maximum at about 60 years (p < 0.001). In the pericentral ring, the mean reduction in retinal thickness per 10-year increase was 2.7 (0.3) lm in women and 4.0 (0.4) lm in men and corresponding results in the peripheral ring were 2.3 (0.3) lmin women and 2.6 (0.4) lmin men. In both regions, there was evidence for a nonlinear pattern with an increased rate of change with higher age. There was a significant interaction between sex and age for retinal thickness of the pericentral ring (p = 0.041). Conclusion: Women had thinner retina than men, and thickness varied with refractive status. Retinal thickness was associated with age in all macular regions, and the rate of change in retinal thickness varied at different ages. |
format |
Article in Journal/Newspaper |
author |
Hanno, Therese von Lade, Anette Caroline Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir |
author_facet |
Hanno, Therese von Lade, Anette Caroline Mathiesen, Ellisiv B. Peto, Tunde Njølstad, Inger Bertelsen, Geir |
author_sort |
Hanno, Therese von |
title |
Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
title_short |
Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
title_full |
Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
title_fullStr |
Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
title_full_unstemmed |
Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) |
title_sort |
macular thickness in healthy eyes of adults (n=4508) and relation to sex, age and refraction: the tromsø eye study (2007-08) |
publisher |
Wiley |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10476 https://doi.org/10.1111/aos.13337 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Acta Ophthalmologica Hanno T, Lade AC, Mathiesen EB, Peto T, Njølstad i, Bertelsen G. Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08). Acta Ophthalmologica. 2016 FRIDAID 1419972 doi:10.1111/aos.13337 1755-375X 1755-3768 https://hdl.handle.net/10037/10476 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1111/aos.13337 |
container_title |
Acta Ophthalmologica |
container_volume |
95 |
container_issue |
3 |
container_start_page |
262 |
op_container_end_page |
269 |
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1766219905580924928 |