Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study
Manuscript. Published version available at http://dx.doi.org/10.1111/jth.13329 Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives: We aimed to study the association between incident myocardial infarction (MI)...
Published in: | Journal of Thrombosis and Haemostasis |
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Online Access: | https://hdl.handle.net/10037/10428 https://doi.org/10.1111/jth.13329 |
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ftunivtroemsoe:oai:munin.uit.no:10037/10428 2023-05-15T18:34:32+02:00 Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study Myocardial infarction and venous thromboembolism Balteskard Rinde, Ludvig Lind, Caroline Småbrekke, Birgit Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Løchen, Maja-Lisa Mathiesen Hald, Erin Vik, Anders Brækkan, Sigrid Kufaas Hansen, John-Bjarne Rinde, Ludvig Balteskard 2016-05-10 https://hdl.handle.net/10037/10428 https://doi.org/10.1111/jth.13329 eng eng Wiley Journal of Thrombosis and Haemostasis Rinde LB, Lind C, Småbrekke B, Njølstad I, Mathiesen EB, Wilsgaard T, Løchen M-L, Hald EM, Vik A, Brækkan SK, Hansen J-B. Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. J Thromb Haemost 2016; 14: 1183–91. FRIDAID 1370911 doi:10.1111/jth.13329 1538-7933 1538-7836 https://hdl.handle.net/10037/10428 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical biochemistry: 726 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1111/jth.13329 2021-06-25T17:55:08Z Manuscript. Published version available at http://dx.doi.org/10.1111/jth.13329 Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 and 2007-08) and followed through 2010. All incident events of MI and VTE during follow-up were recorded. Cox-regression models with age as time scale and MI as a time-dependent variable were used to calculate hazard ratios (HR) of VTE adjusted for sex, BMI, blood pressure, diabetes mellitus, HDL-cholesterol, smoking, physical activity and education level. Results: During a median follow-up of 15.7 years, 1 853 participants experienced a MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% CI 1.08-2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07-2.75), but not significantly associated with risk of deep vein thrombosis (DVT) (HR 1.36, 95% CI, 0.86-2.15). The highest risk estimates for PE were observed during the first sixth months after the MI (HR 8.49; 95% CI 4.00-18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI-patients (attributable risk). Conclusions: Our findings indicate that MI is associated with a transient increased risk of VTE independent of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø Journal of Thrombosis and Haemostasis 14 6 1183 1191 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical biochemistry: 726 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical biochemistry: 726 Balteskard Rinde, Ludvig Lind, Caroline Småbrekke, Birgit Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Løchen, Maja-Lisa Mathiesen Hald, Erin Vik, Anders Brækkan, Sigrid Kufaas Hansen, John-Bjarne Rinde, Ludvig Balteskard Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical biochemistry: 726 |
description |
Manuscript. Published version available at http://dx.doi.org/10.1111/jth.13329 Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 and 2007-08) and followed through 2010. All incident events of MI and VTE during follow-up were recorded. Cox-regression models with age as time scale and MI as a time-dependent variable were used to calculate hazard ratios (HR) of VTE adjusted for sex, BMI, blood pressure, diabetes mellitus, HDL-cholesterol, smoking, physical activity and education level. Results: During a median follow-up of 15.7 years, 1 853 participants experienced a MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% CI 1.08-2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07-2.75), but not significantly associated with risk of deep vein thrombosis (DVT) (HR 1.36, 95% CI, 0.86-2.15). The highest risk estimates for PE were observed during the first sixth months after the MI (HR 8.49; 95% CI 4.00-18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI-patients (attributable risk). Conclusions: Our findings indicate that MI is associated with a transient increased risk of VTE independent of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE. |
format |
Article in Journal/Newspaper |
author |
Balteskard Rinde, Ludvig Lind, Caroline Småbrekke, Birgit Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Løchen, Maja-Lisa Mathiesen Hald, Erin Vik, Anders Brækkan, Sigrid Kufaas Hansen, John-Bjarne Rinde, Ludvig Balteskard |
author_facet |
Balteskard Rinde, Ludvig Lind, Caroline Småbrekke, Birgit Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Løchen, Maja-Lisa Mathiesen Hald, Erin Vik, Anders Brækkan, Sigrid Kufaas Hansen, John-Bjarne Rinde, Ludvig Balteskard |
author_sort |
Balteskard Rinde, Ludvig |
title |
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
title_short |
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
title_full |
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
title_fullStr |
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
title_full_unstemmed |
Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study |
title_sort |
impact of incident myocardial infarction on the risk of venous thromboembolism: the tromsø study |
publisher |
Wiley |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10428 https://doi.org/10.1111/jth.13329 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Journal of Thrombosis and Haemostasis Rinde LB, Lind C, Småbrekke B, Njølstad I, Mathiesen EB, Wilsgaard T, Løchen M-L, Hald EM, Vik A, Brækkan SK, Hansen J-B. Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. J Thromb Haemost 2016; 14: 1183–91. FRIDAID 1370911 doi:10.1111/jth.13329 1538-7933 1538-7836 https://hdl.handle.net/10037/10428 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1111/jth.13329 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
14 |
container_issue |
6 |
container_start_page |
1183 |
op_container_end_page |
1191 |
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1766219312423501824 |