Weight Change and Risk of Venous Thromboembolism: The Tromsø Study
This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article is also available via DOI: 10.1371/journal.pone.01...
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Online Access: | https://hdl.handle.net/10037/10242 https://doi.org/10.1371/journal.pone.0168878 |
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ftunivtroemsoe:oai:munin.uit.no:10037/10242 2023-05-15T18:34:36+02:00 Weight Change and Risk of Venous Thromboembolism: The Tromsø Study Horvei, Lars Daae Brækkan, Sigrid Kufaas Hansen, John-Bjarne 2016-12-20 https://hdl.handle.net/10037/10242 https://doi.org/10.1371/journal.pone.0168878 eng eng Public Library of Science PLoS ONE Stiftelsen Kristian Gerhard Jebsen: SKGJ‐MED‐012 Horvei LD, Brækkan SK, Hansen JB. Weight Change and Risk of Venous Thromboembolism: The Tromsø Study. PLoS ONE (2016), 11(12): e0168878 FRIDAID 1435133 doi:10.1371/journal.pone.0168878 1932-6203 https://hdl.handle.net/10037/10242 openAccess VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::General pathology anatomical pathology: 719 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1371/journal.pone.0168878 2021-06-25T17:55:01Z This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article is also available via DOI: 10.1371/journal.pone.0168878 Background: Obesity is a major risk factor for venous thromboembolism (VTE), but it is unknown to what extent weight change over time affects VTE risk. Aims: To investigate the association between weight change and risk of incident VTE in a population-based cohort with repeated measurements. Methods: Participant data were collected from the Tromsø 3 (1986–87), 4 (1994–95), 5 (2000–01) and 6 (2007–08) surveys. Subjects who attended two subsequent or more surveys were included (n = 17802), and weight change between the surveys was calculated. Person-time at risk was accrued from the second of two subsequent vists until the next survey, the date of an incident VTE, migration, death or study end (December 31st 2012), whichever came first. Cox regression models were used to calculate risk of VTE according to change in body weight. Results: There were 302 incident VTE events during a median of 6.0 years of follow-up. Subjects who gained most weight (7.5–40.0 kg weight gain) had a 1.9-fold higher risk of VTE compared to those with no or a moderate (0–7.4 kg) weight gain (HR 1.92; 95% CI 1.38–2.68). The VTE risk by 7.5 kgs over no or moderate (0–7.4 kg) weight gain was highest (HR 3.75; 95% 1.83–7.68) in subjects with baseline body mass index (BMI) 30 kg/m2 . There was a joint effect of weight gain and baseline BMI on VTE risk. Those with BMI 30 who gained 7.5 kgs had a 6.6-fold increased risk (HR 6.64; 95% CI 3.61–12.22) compared to subjects with BMI <25 and no or moderate (0–7.4 kg) weight gain. Conclusions: Our findings imply that further weight gain is a considerable risk factor for VTE, particularly in obese individuals. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive Tromsø PLOS ONE 11 12 e0168878 |
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University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::General pathology anatomical pathology: 719 |
spellingShingle |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::General pathology anatomical pathology: 719 Horvei, Lars Daae Brækkan, Sigrid Kufaas Hansen, John-Bjarne Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
topic_facet |
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771 VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771 VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::General pathology anatomical pathology: 719 |
description |
This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article is also available via DOI: 10.1371/journal.pone.0168878 Background: Obesity is a major risk factor for venous thromboembolism (VTE), but it is unknown to what extent weight change over time affects VTE risk. Aims: To investigate the association between weight change and risk of incident VTE in a population-based cohort with repeated measurements. Methods: Participant data were collected from the Tromsø 3 (1986–87), 4 (1994–95), 5 (2000–01) and 6 (2007–08) surveys. Subjects who attended two subsequent or more surveys were included (n = 17802), and weight change between the surveys was calculated. Person-time at risk was accrued from the second of two subsequent vists until the next survey, the date of an incident VTE, migration, death or study end (December 31st 2012), whichever came first. Cox regression models were used to calculate risk of VTE according to change in body weight. Results: There were 302 incident VTE events during a median of 6.0 years of follow-up. Subjects who gained most weight (7.5–40.0 kg weight gain) had a 1.9-fold higher risk of VTE compared to those with no or a moderate (0–7.4 kg) weight gain (HR 1.92; 95% CI 1.38–2.68). The VTE risk by 7.5 kgs over no or moderate (0–7.4 kg) weight gain was highest (HR 3.75; 95% 1.83–7.68) in subjects with baseline body mass index (BMI) 30 kg/m2 . There was a joint effect of weight gain and baseline BMI on VTE risk. Those with BMI 30 who gained 7.5 kgs had a 6.6-fold increased risk (HR 6.64; 95% CI 3.61–12.22) compared to subjects with BMI <25 and no or moderate (0–7.4 kg) weight gain. Conclusions: Our findings imply that further weight gain is a considerable risk factor for VTE, particularly in obese individuals. |
format |
Article in Journal/Newspaper |
author |
Horvei, Lars Daae Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Horvei, Lars Daae Brækkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Horvei, Lars Daae |
title |
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
title_short |
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
title_full |
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
title_fullStr |
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
title_full_unstemmed |
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study |
title_sort |
weight change and risk of venous thromboembolism: the tromsø study |
publisher |
Public Library of Science |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10242 https://doi.org/10.1371/journal.pone.0168878 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
PLoS ONE Stiftelsen Kristian Gerhard Jebsen: SKGJ‐MED‐012 Horvei LD, Brækkan SK, Hansen JB. Weight Change and Risk of Venous Thromboembolism: The Tromsø Study. PLoS ONE (2016), 11(12): e0168878 FRIDAID 1435133 doi:10.1371/journal.pone.0168878 1932-6203 https://hdl.handle.net/10037/10242 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0168878 |
container_title |
PLOS ONE |
container_volume |
11 |
container_issue |
12 |
container_start_page |
e0168878 |
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