Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
Source at https://doi.org/10.1186/s12882-016-0386-4 . Background - Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity i...
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Online Access: | https://hdl.handle.net/10037/10163 https://doi.org/10.1186/s12882-016-0386-4 |
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ftunivtroemsoe:oai:munin.uit.no:10037/10163 2023-05-15T18:34:54+02:00 Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study Stefansson, Vidar Tor Nyborg Schei, Jørgen Jenssen, Trond Geir Melsom, Toralf Eriksen, Bjørn Odvar 2016-11-10 https://hdl.handle.net/10037/10163 https://doi.org/10.1186/s12882-016-0386-4 eng eng BioMed Central Stefansson, V.T.R. (2019). Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population. (Doctoral thesis). https://hdl.handle.net/10037/15611 . Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study. BMC Nephrology, 17 , 172. https://doi.org/10.1186/s12882-016-0386-4 FRIDAID 1415017 doi:10.1186/s12882-016-0386-4 1471-2369 https://hdl.handle.net/10037/10163 openAccess Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Journal article Tidsskriftartikkel Peer reviewed 2016 ftunivtroemsoe https://doi.org/10.1186/s12882-016-0386-4 2021-06-25T17:54:59Z Source at https://doi.org/10.1186/s12882-016-0386-4 . Background - Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods - 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results - In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions - Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. Article in Journal/Newspaper Tromsø University of Tromsø: Munin Open Research Archive The Waist ENVELOPE(-61.404,-61.404,-64.639,-64.639) Tromsø BMC Nephrology 17 1 |
institution |
Open Polar |
collection |
University of Tromsø: Munin Open Research Archive |
op_collection_id |
ftunivtroemsoe |
language |
English |
topic |
Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
spellingShingle |
Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 Stefansson, Vidar Tor Nyborg Schei, Jørgen Jenssen, Trond Geir Melsom, Toralf Eriksen, Bjørn Odvar Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
topic_facet |
Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 |
description |
Source at https://doi.org/10.1186/s12882-016-0386-4 . Background - Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods - 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results - In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions - Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. |
format |
Article in Journal/Newspaper |
author |
Stefansson, Vidar Tor Nyborg Schei, Jørgen Jenssen, Trond Geir Melsom, Toralf Eriksen, Bjørn Odvar |
author_facet |
Stefansson, Vidar Tor Nyborg Schei, Jørgen Jenssen, Trond Geir Melsom, Toralf Eriksen, Bjørn Odvar |
author_sort |
Stefansson, Vidar Tor Nyborg |
title |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_short |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_fullStr |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full_unstemmed |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_sort |
central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
publisher |
BioMed Central |
publishDate |
2016 |
url |
https://hdl.handle.net/10037/10163 https://doi.org/10.1186/s12882-016-0386-4 |
long_lat |
ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
geographic |
The Waist Tromsø |
geographic_facet |
The Waist Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
Stefansson, V.T.R. (2019). Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population. (Doctoral thesis). https://hdl.handle.net/10037/15611 . Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study. BMC Nephrology, 17 , 172. https://doi.org/10.1186/s12882-016-0386-4 FRIDAID 1415017 doi:10.1186/s12882-016-0386-4 1471-2369 https://hdl.handle.net/10037/10163 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1186/s12882-016-0386-4 |
container_title |
BMC Nephrology |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766219904973799424 |