Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B
The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(e-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl...
Published in: | Journal of Applied Polymer Science |
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Language: | English |
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John Wiley & Sons
2016
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Online Access: | http://oatao.univ-toulouse.fr/18209/ http://oatao.univ-toulouse.fr/18209/1/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 |
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ftunivtoulouseoa:oai:oatao.univ-toulouse.fr:18209 2023-05-15T13:32:48+02:00 Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle Centre National de la Recherche Scientifique - CNRS (FRANCE) Institut National Polytechnique de Toulouse - INPT (FRANCE) Université Toulouse III - Paul Sabatier - UPS (FRANCE) Kazimierz Pułaski University of Technology and Humanities in Radom (POLAND) Medical University of Warsaw - WUM (POLAND) 2016-04-28 application/pdf http://oatao.univ-toulouse.fr/18209/ http://oatao.univ-toulouse.fr/18209/1/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 en eng John Wiley & Sons http://oatao.univ-toulouse.fr/18209/1/Piotrowska_18209.pdf HAL : hal-01644363 Piotrowska, Urszula and Sobczak, Marcin and Oledzka, Ewa and Combes, Christèle. Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B. (2016) Journal of Applied Polymer Science, 133 (31). ISSN 0021-8995 info:eu-repo/semantics/openAccess Génie chimique Matériaux Degradation Drug delivery systems Ionic liquids Polyesters Properties and characterization Article PeerReviewed info:eu-repo/semantics/article 2016 ftunivtoulouseoa https://doi.org/10.1002/app.43728 2019-08-29T11:22:12Z The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(e-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 8C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10–14% at 80 8C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers. Article in Journal/Newspaper Antarc* Antarctica OATAO (Open Archive Toulouse Archive Ouverte - Université de Toulouse) Journal of Applied Polymer Science 133 31 |
institution |
Open Polar |
collection |
OATAO (Open Archive Toulouse Archive Ouverte - Université de Toulouse) |
op_collection_id |
ftunivtoulouseoa |
language |
English |
topic |
Génie chimique Matériaux Degradation Drug delivery systems Ionic liquids Polyesters Properties and characterization |
spellingShingle |
Génie chimique Matériaux Degradation Drug delivery systems Ionic liquids Polyesters Properties and characterization Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
topic_facet |
Génie chimique Matériaux Degradation Drug delivery systems Ionic liquids Polyesters Properties and characterization |
description |
The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(e-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 8C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10–14% at 80 8C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers. |
author2 |
Centre National de la Recherche Scientifique - CNRS (FRANCE) Institut National Polytechnique de Toulouse - INPT (FRANCE) Université Toulouse III - Paul Sabatier - UPS (FRANCE) Kazimierz Pułaski University of Technology and Humanities in Radom (POLAND) Medical University of Warsaw - WUM (POLAND) |
format |
Article in Journal/Newspaper |
author |
Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle |
author_facet |
Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle |
author_sort |
Piotrowska, Urszula |
title |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_short |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_full |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_fullStr |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_full_unstemmed |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_sort |
effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of candida antarctica lipase b |
publisher |
John Wiley & Sons |
publishDate |
2016 |
url |
http://oatao.univ-toulouse.fr/18209/ http://oatao.univ-toulouse.fr/18209/1/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://oatao.univ-toulouse.fr/18209/1/Piotrowska_18209.pdf HAL : hal-01644363 Piotrowska, Urszula and Sobczak, Marcin and Oledzka, Ewa and Combes, Christèle. Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B. (2016) Journal of Applied Polymer Science, 133 (31). ISSN 0021-8995 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1002/app.43728 |
container_title |
Journal of Applied Polymer Science |
container_volume |
133 |
container_issue |
31 |
_version_ |
1766035946510221312 |