Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario
In Canada, an estimated 220,000-246,000 people currently live with chronic hepatitis C viral (HCV) infection. To achieve the goals set by the World Health Organization (WHO) strategy to eliminate HCV infection by 2030, a mandate for action in the form of the Blueprint to Inform Hepatitis C Eliminati...
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ftunivtoronto:oai:tspace.library.utoronto.ca:1807/109138 2023-05-15T16:13:59+02:00 Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario Mendlowitz, Andrew Bryan Krahn, Murray Isaranuwatchai, Wanrudee Health Policy, Management and Evaluation 2021-11-30T18:53:06Z application/pdf http://hdl.handle.net/1807/109138 unknown University of Toronto http://hdl.handle.net/1807/109138 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ CC-BY-NC-ND First Nations Health Health Economics Health Services Research Hepatitis C Indigenous Health 0573 Thesis 2021 ftunivtoronto 2021-12-05T18:17:08Z In Canada, an estimated 220,000-246,000 people currently live with chronic hepatitis C viral (HCV) infection. To achieve the goals set by the World Health Organization (WHO) strategy to eliminate HCV infection by 2030, a mandate for action in the form of the Blueprint to Inform Hepatitis C Elimination Efforts in Canada was released. The Blueprint outlines what is necessary to achieve HCV elimination in Canada, emphasizing the need to inform specific knowledge gaps and calling on provinces/territories to develop action plans to meet the WHO targets for viral elimination. As a part of Canada’s commitment to the WHO strategy and the Blueprint, Canada has made First Nations-led approaches and First Nations populations a priority focus for national and provincial/territorial HCV strategies. Therefore, the purpose of this thesis is to generate evidence that can inform policy options for HCV elimination efforts in First Nations populations in Ontario. In Ontario, recent negotiations have allowed for partnerships between academic researchers and First Nations organizations to perform First Nations-directed research using administrative health data. In partnership with the Ontario First Nations HIV/AIDS Education Circle (OFNHAEC), we examined the health and economic impacts of HCV on Status First Nations populations in Ontario. The first study explored trends in the epidemiology and testing for HCV among a cohort of Status First Nations individuals across Ontario. The second study estimated the provincial publicly-funded healthcare costs associated with HCV among a cohort of Status First Nations individuals in Ontario. The third study uses the example of HCV screening within the emergency department setting to demonstrate how existing research can be used to perform economic evaluations of novel HCV case-finding approaches. With future work and using the evidence generated from this thesis, a similar approach can be used to evaluate First Nations-specific HCV interventions. Collectively, these studies inform research gaps necessary to reach the WHO goals for viral elimination and serve as reference in beginning to understand the impact of infection among First Nations individuals in Ontario. The data presented by this dissertation provides decision-makers with evidence that can inform the creation of HCV policy, prevention, and treatment efforts. Ph.D. Thesis First Nations University of Toronto: Research Repository T-Space Canada |
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University of Toronto: Research Repository T-Space |
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ftunivtoronto |
language |
unknown |
topic |
First Nations Health Health Economics Health Services Research Hepatitis C Indigenous Health 0573 |
spellingShingle |
First Nations Health Health Economics Health Services Research Hepatitis C Indigenous Health 0573 Mendlowitz, Andrew Bryan Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
topic_facet |
First Nations Health Health Economics Health Services Research Hepatitis C Indigenous Health 0573 |
description |
In Canada, an estimated 220,000-246,000 people currently live with chronic hepatitis C viral (HCV) infection. To achieve the goals set by the World Health Organization (WHO) strategy to eliminate HCV infection by 2030, a mandate for action in the form of the Blueprint to Inform Hepatitis C Elimination Efforts in Canada was released. The Blueprint outlines what is necessary to achieve HCV elimination in Canada, emphasizing the need to inform specific knowledge gaps and calling on provinces/territories to develop action plans to meet the WHO targets for viral elimination. As a part of Canada’s commitment to the WHO strategy and the Blueprint, Canada has made First Nations-led approaches and First Nations populations a priority focus for national and provincial/territorial HCV strategies. Therefore, the purpose of this thesis is to generate evidence that can inform policy options for HCV elimination efforts in First Nations populations in Ontario. In Ontario, recent negotiations have allowed for partnerships between academic researchers and First Nations organizations to perform First Nations-directed research using administrative health data. In partnership with the Ontario First Nations HIV/AIDS Education Circle (OFNHAEC), we examined the health and economic impacts of HCV on Status First Nations populations in Ontario. The first study explored trends in the epidemiology and testing for HCV among a cohort of Status First Nations individuals across Ontario. The second study estimated the provincial publicly-funded healthcare costs associated with HCV among a cohort of Status First Nations individuals in Ontario. The third study uses the example of HCV screening within the emergency department setting to demonstrate how existing research can be used to perform economic evaluations of novel HCV case-finding approaches. With future work and using the evidence generated from this thesis, a similar approach can be used to evaluate First Nations-specific HCV interventions. Collectively, these studies inform research gaps necessary to reach the WHO goals for viral elimination and serve as reference in beginning to understand the impact of infection among First Nations individuals in Ontario. The data presented by this dissertation provides decision-makers with evidence that can inform the creation of HCV policy, prevention, and treatment efforts. Ph.D. |
author2 |
Krahn, Murray Isaranuwatchai, Wanrudee Health Policy, Management and Evaluation |
format |
Thesis |
author |
Mendlowitz, Andrew Bryan |
author_facet |
Mendlowitz, Andrew Bryan |
author_sort |
Mendlowitz, Andrew Bryan |
title |
Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
title_short |
Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
title_full |
Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
title_fullStr |
Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
title_full_unstemmed |
Evidence to Inform Policy Options for the Elimination of Hepatitis C Virus in First Nations Populations in Ontario |
title_sort |
evidence to inform policy options for the elimination of hepatitis c virus in first nations populations in ontario |
publisher |
University of Toronto |
publishDate |
2021 |
url |
http://hdl.handle.net/1807/109138 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
First Nations |
genre_facet |
First Nations |
op_relation |
http://hdl.handle.net/1807/109138 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_rightsnorm |
CC-BY-NC-ND |
_version_ |
1765999825973673984 |