Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study
Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Natio...
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ftunivtoronto:oai:localhost:1807/83538 2023-05-15T16:17:01+02:00 Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study Zacharias, James M Young, T K Riediger, Natalie D Roulette, Joanne Bruce, Sharon G 2012-04-20 http://hdl.handle.net/1807/83538 https://doi.org/10.1186/1471-2458-12-290 en eng BMC Public Health. 2012 Apr 20;12(1):290 http://dx.doi.org/10.1186/1471-2458-12-290 http://hdl.handle.net/1807/83538 Zacharias et al; licensee BioMed Central Ltd. Journal Article 2012 ftunivtoronto https://doi.org/10.1186/1471-2458-12-290 2020-06-17T12:11:54Z Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A1c, triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. Article in Journal/Newspaper First Nations University of Toronto: Research Repository T-Space BMC Public Health 12 1 |
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University of Toronto: Research Repository T-Space |
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English |
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Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A1c, triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. |
format |
Article in Journal/Newspaper |
author |
Zacharias, James M Young, T K Riediger, Natalie D Roulette, Joanne Bruce, Sharon G |
spellingShingle |
Zacharias, James M Young, T K Riediger, Natalie D Roulette, Joanne Bruce, Sharon G Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
author_facet |
Zacharias, James M Young, T K Riediger, Natalie D Roulette, Joanne Bruce, Sharon G |
author_sort |
Zacharias, James M |
title |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_short |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_fullStr |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full_unstemmed |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_sort |
prevalence, risk factors and awareness of albuminuria on a canadian first nation: a community-based screening study |
publishDate |
2012 |
url |
http://hdl.handle.net/1807/83538 https://doi.org/10.1186/1471-2458-12-290 |
genre |
First Nations |
genre_facet |
First Nations |
op_relation |
BMC Public Health. 2012 Apr 20;12(1):290 http://dx.doi.org/10.1186/1471-2458-12-290 http://hdl.handle.net/1807/83538 |
op_rights |
Zacharias et al; licensee BioMed Central Ltd. |
op_doi |
https://doi.org/10.1186/1471-2458-12-290 |
container_title |
BMC Public Health |
container_volume |
12 |
container_issue |
1 |
_version_ |
1766002871218733056 |