European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

• Published in: Human Molecular Genetics
• Main Authors: Rafnar T, Vermeulen SH, Sulem P, Thorleifsson G, Aben KK, Witjes JA, Grotenhuis AJ, Verhaegh GW, Hulsbergen van de Kaa CA, Besenbacher S, Gudbjartsson D, Stacey SN, Gudmundsson J, Johannsdottir H, Bjarnason H, Zanon C, Helgadottir H, Jonasson JG, Tryggvadottir L, Jonsson E, Geirsson G, Nikulasson S, Petursdottir V, Bishop DT, Chung Sak S, Choudhury A, Elliott F, Barrett JH, Knowles MA, de Verdier PJ, Ryk C, Lindblom A, Rudnai P, Gurzau E, Koppova K, Panadero A, Sanz Velez JI, Sanchez M, Valdivia G, Garcia Prats MD, Hengstler JG, Selinski S, Gerullis H, Ovsiannikov D, Khezri A, Aminsharifi A, Malekzadeh M, van den Berg LH, Ophoff RA, Veldink JH, Zeegers MP, Kellen E, Fostinelli J, Andreoli D, Arici C, Porru S, Buntinx F, Ghaderi A, Golka K, Mayordomo JI, Kumar R, Steineck G, Kiltie AE, Kong A, Thorsteinsdottir U, Stefansson K, Kiemeney LA, VINEIS, Paolo, POLIDORO, Silvia, GUARRERA, Simonetta, SACERDOTE, Carlotta, MATULLO, Giuseppe
• Other Authors: Hulsbergen-van de Kaa CA, Chung-Sak S, Vineis P, Polidoro S, Guarrera S, Sacerdote C, Sanz-Velez JI, Garcia-Prats MD
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2011
• Subjects: Bladder cancer; genome-wide association; Kidd; Iceland
• Online Access: http://hdl.handle.net/2318/88685; https://doi.org/10.1093/hmg/ddr303; http://hmg.oxfordjournals.org/content/early/2011/07/22/hmg.ddr303.full.pdf+html

Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European G...