Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo
Background SARS-CoV-2 is believed to have originated from a spillover event, where the virus jumped from bats to humans, leading to an epidemic that quickly escalated into a pandemic by early 2020. Despite the implementation of various public health measures, such as lockdowns and widespread vaccina...
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Online Access: | http://ir.unimas.my/id/eprint/44644/ https://bmcvetres.biomedcentral.com/ https://doi.org/10.1186/s12917-024-03892-5 http://ir.unimas.my/id/eprint/44644/1/s12917-024-03892-5 |
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ftunivtmara:oai:ir.unimas.my:44644 2024-05-19T07:47:43+00:00 Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo Tan, Cheng Siang Madinah, Adrus Sultana Parvin, Habeebur-Rahman Haziq Izzuddin, Muhamad Azman Riz Anasthasia, Alta Abang 2024 text http://ir.unimas.my/id/eprint/44644/ https://bmcvetres.biomedcentral.com/ https://doi.org/10.1186/s12917-024-03892-5 http://ir.unimas.my/id/eprint/44644/1/s12917-024-03892-5 en eng Biomed Central http://ir.unimas.my/id/eprint/44644/1/s12917-024-03892-5 Tan, Cheng Siang and Madinah, Adrus and Sultana Parvin, Habeebur-Rahman and Haziq Izzuddin, Muhamad Azman and Riz Anasthasia, Alta Abang (2024) Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo. BMC Veterinary Research, 20 (161). ISSN 1746-6148 QL Zoology QR355 Virology Article PeerReviewed 2024 ftunivtmara https://doi.org/10.1186/s12917-024-03892-5 2024-05-01T02:35:56Z Background SARS-CoV-2 is believed to have originated from a spillover event, where the virus jumped from bats to humans, leading to an epidemic that quickly escalated into a pandemic by early 2020. Despite the implementation of various public health measures, such as lockdowns and widespread vaccination efforts, the virus continues to spread. This is primarily attributed to the rapid emergence of immune escape variants and the inadequacy of protection against reinfection. Spillback events were reported early in animals with frequent contact with humans, especially companion, captive, and farmed animals. Unfortunately, surveillance of spillback events is generally lacking in Malaysia. Therefore, this study aims to address this gap by investigating the presence of SARS-CoV-2 neutralising antibodies in wild rodents in Sarawak, Malaysia. Results We analysed 208 archived plasma from rodents collected between from 2018 to 2022 to detect neutralising antibodies against SARS-CoV-2 using a surrogate virus neutralisation test, and discovered two seropositive rodents (Sundamys muelleri and Rattus rattus), which were sampled in 2021 and 2022, respectively. Conclusion Our findings suggest that Sundamys muelleri and Rattus rattus may be susceptible to natural SARS-CoV-2 infections. However, there is currently no evidence supporting sustainable rodent-to-rodent transmission. Article in Journal/Newspaper Rattus rattus UiTM Digital Repository (Universiti Teknologi Mara) BMC Veterinary Research 20 1 |
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UiTM Digital Repository (Universiti Teknologi Mara) |
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language |
English |
topic |
QL Zoology QR355 Virology |
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QL Zoology QR355 Virology Tan, Cheng Siang Madinah, Adrus Sultana Parvin, Habeebur-Rahman Haziq Izzuddin, Muhamad Azman Riz Anasthasia, Alta Abang Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
topic_facet |
QL Zoology QR355 Virology |
description |
Background SARS-CoV-2 is believed to have originated from a spillover event, where the virus jumped from bats to humans, leading to an epidemic that quickly escalated into a pandemic by early 2020. Despite the implementation of various public health measures, such as lockdowns and widespread vaccination efforts, the virus continues to spread. This is primarily attributed to the rapid emergence of immune escape variants and the inadequacy of protection against reinfection. Spillback events were reported early in animals with frequent contact with humans, especially companion, captive, and farmed animals. Unfortunately, surveillance of spillback events is generally lacking in Malaysia. Therefore, this study aims to address this gap by investigating the presence of SARS-CoV-2 neutralising antibodies in wild rodents in Sarawak, Malaysia. Results We analysed 208 archived plasma from rodents collected between from 2018 to 2022 to detect neutralising antibodies against SARS-CoV-2 using a surrogate virus neutralisation test, and discovered two seropositive rodents (Sundamys muelleri and Rattus rattus), which were sampled in 2021 and 2022, respectively. Conclusion Our findings suggest that Sundamys muelleri and Rattus rattus may be susceptible to natural SARS-CoV-2 infections. However, there is currently no evidence supporting sustainable rodent-to-rodent transmission. |
format |
Article in Journal/Newspaper |
author |
Tan, Cheng Siang Madinah, Adrus Sultana Parvin, Habeebur-Rahman Haziq Izzuddin, Muhamad Azman Riz Anasthasia, Alta Abang |
author_facet |
Tan, Cheng Siang Madinah, Adrus Sultana Parvin, Habeebur-Rahman Haziq Izzuddin, Muhamad Azman Riz Anasthasia, Alta Abang |
author_sort |
Tan, Cheng Siang |
title |
Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
title_short |
Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
title_full |
Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
title_fullStr |
Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
title_full_unstemmed |
Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo |
title_sort |
seroevidence of sars-cov-2 spillback to rodents in sarawak, malaysian borneo |
publisher |
Biomed Central |
publishDate |
2024 |
url |
http://ir.unimas.my/id/eprint/44644/ https://bmcvetres.biomedcentral.com/ https://doi.org/10.1186/s12917-024-03892-5 http://ir.unimas.my/id/eprint/44644/1/s12917-024-03892-5 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://ir.unimas.my/id/eprint/44644/1/s12917-024-03892-5 Tan, Cheng Siang and Madinah, Adrus and Sultana Parvin, Habeebur-Rahman and Haziq Izzuddin, Muhamad Azman and Riz Anasthasia, Alta Abang (2024) Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo. BMC Veterinary Research, 20 (161). ISSN 1746-6148 |
op_doi |
https://doi.org/10.1186/s12917-024-03892-5 |
container_title |
BMC Veterinary Research |
container_volume |
20 |
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1 |
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1799488178932940800 |