Influenza A virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for...
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2010
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ftunivtexas:oai:repositories.lib.utexas.edu:2152/77022 2023-05-15T15:34:21+02:00 Influenza A virus vaccines and inhibitors Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Board of Regents, The University of Texas System 2010-05-04 application/pdf https://hdl.handle.net/2152/77022 https://doi.org/10.26153/tsw/4111 unknown United States Patent and Trademark Office University of Texas Patents https://hdl.handle.net/2152/77022 http://dx.doi.org/10.26153/tsw/4111 7709190 11566216 Open A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/5 Patent 2010 ftunivtexas https://doi.org/10.26153/tsw/4111 2020-12-23T22:01:55Z The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System Patent Avian flu The University of Texas at Austin: Texas ScholarWorks |
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The University of Texas at Austin: Texas ScholarWorks |
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ftunivtexas |
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unknown |
topic |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/5 |
spellingShingle |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/5 Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Influenza A virus vaccines and inhibitors |
topic_facet |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/5 |
description |
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System |
author2 |
Board of Regents, The University of Texas System |
format |
Patent |
author |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_facet |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_sort |
Edward C. Arnold |
title |
Influenza A virus vaccines and inhibitors |
title_short |
Influenza A virus vaccines and inhibitors |
title_full |
Influenza A virus vaccines and inhibitors |
title_fullStr |
Influenza A virus vaccines and inhibitors |
title_full_unstemmed |
Influenza A virus vaccines and inhibitors |
title_sort |
influenza a virus vaccines and inhibitors |
publisher |
United States Patent and Trademark Office |
publishDate |
2010 |
url |
https://hdl.handle.net/2152/77022 https://doi.org/10.26153/tsw/4111 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
University of Texas Patents https://hdl.handle.net/2152/77022 http://dx.doi.org/10.26153/tsw/4111 7709190 11566216 |
op_rights |
Open |
op_doi |
https://doi.org/10.26153/tsw/4111 |
_version_ |
1766364773684871168 |