Influenza A virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for...
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United States Patent and Trademark Office
2015
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ftunivtexas:oai:repositories.lib.utexas.edu:2152/76671 2023-05-15T15:34:21+02:00 Influenza A virus vaccines and inhibitors Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Board of Regents, The University of Texas System Rutgers, The State University of New Jersey 2015-07-14 application/pdf https://hdl.handle.net/2152/76671 https://doi.org/10.26153/tsw/3760 unknown United States Patent and Trademark Office University of Texas Patents https://hdl.handle.net/2152/76671 http://dx.doi.org/10.26153/tsw/3760 9079944 14543258 Open A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 No longer published Patent 2015 ftunivtexas https://doi.org/10.26153/tsw/3760 2020-12-23T22:18:24Z The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System Patent Avian flu The University of Texas at Austin: Texas ScholarWorks |
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Open Polar |
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The University of Texas at Austin: Texas ScholarWorks |
op_collection_id |
ftunivtexas |
language |
unknown |
topic |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 No longer published |
spellingShingle |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 No longer published Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Influenza A virus vaccines and inhibitors |
topic_facet |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 No longer published |
description |
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System |
author2 |
Board of Regents, The University of Texas System Rutgers, The State University of New Jersey |
format |
Patent |
author |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_facet |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_sort |
Edward C. Arnold |
title |
Influenza A virus vaccines and inhibitors |
title_short |
Influenza A virus vaccines and inhibitors |
title_full |
Influenza A virus vaccines and inhibitors |
title_fullStr |
Influenza A virus vaccines and inhibitors |
title_full_unstemmed |
Influenza A virus vaccines and inhibitors |
title_sort |
influenza a virus vaccines and inhibitors |
publisher |
United States Patent and Trademark Office |
publishDate |
2015 |
url |
https://hdl.handle.net/2152/76671 https://doi.org/10.26153/tsw/3760 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
University of Texas Patents https://hdl.handle.net/2152/76671 http://dx.doi.org/10.26153/tsw/3760 9079944 14543258 |
op_rights |
Open |
op_doi |
https://doi.org/10.26153/tsw/3760 |
_version_ |
1766364774040338432 |