Influenza A virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for...
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2014
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ftunivtexas:oai:repositories.lib.utexas.edu:2152/76423 2023-05-15T15:34:21+02:00 Influenza A virus vaccines and inhibitors Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Board of Regents, The University of Texas System Rutgers, The State University of New Jersey 2014-08-05 application/pdf https://hdl.handle.net/2152/76423 https://doi.org/10.26153/tsw/3512 unknown United States Patent and Trademark Office University of Texas Patents https://hdl.handle.net/2152/76423 http://dx.doi.org/10.26153/tsw/3512 8796008 13907472 Open A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 Patent 2014 ftunivtexas https://doi.org/10.26153/tsw/3512 2020-12-23T22:18:16Z The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System Patent Avian flu The University of Texas at Austin: Texas ScholarWorks |
institution |
Open Polar |
collection |
The University of Texas at Austin: Texas ScholarWorks |
op_collection_id |
ftunivtexas |
language |
unknown |
topic |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 |
spellingShingle |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo Influenza A virus vaccines and inhibitors |
topic_facet |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 |
description |
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Board of Regents, University of Texas System |
author2 |
Board of Regents, The University of Texas System Rutgers, The State University of New Jersey |
format |
Patent |
author |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_facet |
Edward C. Arnold Robert M. Krug Karen Y. Twu Gaetano T. Montelione Kalyan Kumar Das Li-Chung Ma Rong Xiao Rei-Lin Kuo |
author_sort |
Edward C. Arnold |
title |
Influenza A virus vaccines and inhibitors |
title_short |
Influenza A virus vaccines and inhibitors |
title_full |
Influenza A virus vaccines and inhibitors |
title_fullStr |
Influenza A virus vaccines and inhibitors |
title_full_unstemmed |
Influenza A virus vaccines and inhibitors |
title_sort |
influenza a virus vaccines and inhibitors |
publisher |
United States Patent and Trademark Office |
publishDate |
2014 |
url |
https://hdl.handle.net/2152/76423 https://doi.org/10.26153/tsw/3512 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
University of Texas Patents https://hdl.handle.net/2152/76423 http://dx.doi.org/10.26153/tsw/3512 8796008 13907472 |
op_rights |
Open |
op_doi |
https://doi.org/10.26153/tsw/3512 |
_version_ |
1766364780629590016 |