Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper 70 virus (PDV), represent a growing threat for marine mammals on both hemispheres. Since free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity related genes and virus cell entry rece...
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ftunivteramo:oai:research.unite.it:11575/98035 2024-04-14T08:18:23+00:00 Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr Yes Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr 2017 STAMPA http://hdl.handle.net/11575/98035 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000415933600003 journal:HLA http://hdl.handle.net/11575/98035 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85034423447 Cetacea Immunity innate Haplotype MHC-DQB Polymorphism Single nucleotide Phocoena phocoena Stenella coeruleoalba info:eu-repo/semantics/article 2017 ftunivteramo 2024-03-21T15:31:49Z Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper 70 virus (PDV), represent a growing threat for marine mammals on both hemispheres. Since free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced eleven candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3,7,8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to Morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. Article in Journal/Newspaper Phocoena phocoena IRIS Universita degli Studi di Teramo |
institution |
Open Polar |
collection |
IRIS Universita degli Studi di Teramo |
op_collection_id |
ftunivteramo |
language |
English |
topic |
Cetacea Immunity innate Haplotype MHC-DQB Polymorphism Single nucleotide Phocoena phocoena Stenella coeruleoalba |
spellingShingle |
Cetacea Immunity innate Haplotype MHC-DQB Polymorphism Single nucleotide Phocoena phocoena Stenella coeruleoalba Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
topic_facet |
Cetacea Immunity innate Haplotype MHC-DQB Polymorphism Single nucleotide Phocoena phocoena Stenella coeruleoalba |
description |
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper 70 virus (PDV), represent a growing threat for marine mammals on both hemispheres. Since free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced eleven candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3,7,8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to Morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. |
author2 |
Yes Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr |
format |
Article in Journal/Newspaper |
author |
Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr |
author_facet |
Stejskalova, Karla Bayerova, Zuzana Futas, Jan Hrazdilova, Kristyna Klumplerova, Marie Oppelt, Jan Splichalova, Petra DI GUARDO, Giovanni Mazzariol, Sandro DI FRANCESCO, Cristina Esmeralda Di Francesco, Gabriella Terracciano, Giuliana Paiu, Romulus Marian Ursache, Teodor Dan Modry, David Horin, Petr |
author_sort |
Stejskalova, Karla |
title |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
title_short |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
title_full |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
title_fullStr |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
title_full_unstemmed |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to Morbillivirus infection in stranded Cetaceans |
title_sort |
candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded cetaceans |
publishDate |
2017 |
url |
http://hdl.handle.net/11575/98035 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000415933600003 journal:HLA http://hdl.handle.net/11575/98035 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85034423447 |
_version_ |
1796317863719469056 |