Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus)
Dolphin Morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that...
Published in: | Frontiers in Microbiology |
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Online Access: | http://hdl.handle.net/11575/94767 https://doi.org/10.3389/fmicb.2016.02011 |
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ftunivteramo:oai:research.unite.it:11575/94767 2024-04-14T08:09:29+00:00 Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) Giorgia Beffagna Cinzia Centelleghe Giovanni Franzo Sandro Mazzariol DI GUARDO, Giovanni Yes Giorgia, Beffagna Cinzia, Centelleghe Giovanni, Franzo DI GUARDO, Giovanni Sandro, Mazzariol 2017 ELETTRONICO http://hdl.handle.net/11575/94767 https://doi.org/10.3389/fmicb.2016.02011 eng eng info:eu-repo/semantics/altIdentifier/pmid/28134317 info:eu-repo/semantics/altIdentifier/wos/WOS:000389547900001 volume:7 journal:SCIENTIFIC REPORTS http://hdl.handle.net/11575/94767 doi:10.3389/fmicb.2016.02011 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011269418 Morbillivirus Dolphin Morbillivirus Viral genes Viral structure Virus-host interaction Fin whale Balaenoptera physalus Mediterranean Sea info:eu-repo/semantics/article 2017 ftunivteramo https://doi.org/10.3389/fmicb.2016.02011 2024-03-21T15:31:08Z Dolphin Morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-‘92 and the 2006-‘08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells. Article in Journal/Newspaper Balaenoptera physalus Fin whale IRIS Universita degli Studi di Teramo Frontiers in Microbiology 7 |
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Open Polar |
collection |
IRIS Universita degli Studi di Teramo |
op_collection_id |
ftunivteramo |
language |
English |
topic |
Morbillivirus Dolphin Morbillivirus Viral genes Viral structure Virus-host interaction Fin whale Balaenoptera physalus Mediterranean Sea |
spellingShingle |
Morbillivirus Dolphin Morbillivirus Viral genes Viral structure Virus-host interaction Fin whale Balaenoptera physalus Mediterranean Sea Giorgia Beffagna Cinzia Centelleghe Giovanni Franzo Sandro Mazzariol DI GUARDO, Giovanni Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
topic_facet |
Morbillivirus Dolphin Morbillivirus Viral genes Viral structure Virus-host interaction Fin whale Balaenoptera physalus Mediterranean Sea |
description |
Dolphin Morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-‘92 and the 2006-‘08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells. |
author2 |
Yes Giorgia, Beffagna Cinzia, Centelleghe Giovanni, Franzo DI GUARDO, Giovanni Sandro, Mazzariol |
format |
Article in Journal/Newspaper |
author |
Giorgia Beffagna Cinzia Centelleghe Giovanni Franzo Sandro Mazzariol DI GUARDO, Giovanni |
author_facet |
Giorgia Beffagna Cinzia Centelleghe Giovanni Franzo Sandro Mazzariol DI GUARDO, Giovanni |
author_sort |
Giorgia Beffagna |
title |
Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
title_short |
Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
title_full |
Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
title_fullStr |
Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
title_full_unstemmed |
Genomic and structural investigation on Dolphin Morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus) |
title_sort |
genomic and structural investigation on dolphin morbillivirus (dmv) in mediterranean fin whales (balaenoptera physalus) |
publishDate |
2017 |
url |
http://hdl.handle.net/11575/94767 https://doi.org/10.3389/fmicb.2016.02011 |
genre |
Balaenoptera physalus Fin whale |
genre_facet |
Balaenoptera physalus Fin whale |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28134317 info:eu-repo/semantics/altIdentifier/wos/WOS:000389547900001 volume:7 journal:SCIENTIFIC REPORTS http://hdl.handle.net/11575/94767 doi:10.3389/fmicb.2016.02011 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011269418 |
op_doi |
https://doi.org/10.3389/fmicb.2016.02011 |
container_title |
Frontiers in Microbiology |
container_volume |
7 |
_version_ |
1796306982367395840 |