Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature
Background Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic funct...
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2018
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Online Access: | https://eprints.utas.edu.au/26190/ https://eprints.utas.edu.au/26190/1/BMC%20genomics_Nuez.pdf https://doi.org/10.1186/s12864-018-4517-0 |
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ftunivtasmania:oai:eprints.utas.edu.au:26190 2023-05-15T15:28:48+02:00 Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature Nuez-Ortin, WG Carter, CG Nichols, PD Cooke, IR Wilson, R 2018 application/pdf https://eprints.utas.edu.au/26190/ https://eprints.utas.edu.au/26190/1/BMC%20genomics_Nuez.pdf https://doi.org/10.1186/s12864-018-4517-0 en eng Biomed Central Ltd https://eprints.utas.edu.au/26190/1/BMC%20genomics_Nuez.pdf Nuez-Ortin, WG, Carter, CG orcid:0000-0001-5210-1282 , Nichols, PD, Cooke, IR and Wilson, R orcid:0000-0003-0152-4394 2018 , 'Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature' , BMC Genomics, vol. 19 , pp. 1-13 , doi:10.1186/s12864-018-4517-0 <http://dx.doi.org/10.1186/s12864-018-4517-0>. aquaculture Atlantic salmon climate change proteomics adaptation Article PeerReviewed 2018 ftunivtasmania https://doi.org/10.1186/s12864-018-4517-0 2021-09-20T22:16:35Z Background Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in thermal adaptation. With the aim of identifying mechanisms underlying liver plasticity in response to chronic elevated temperature in Atlantic salmon, label-free shotgun proteomics was used to explore quantitative protein changes after 43 days of exposure to elevated temperature. Results A total of 276 proteins were differentially (adjusted p-value °C) and elevated (21 °C) temperature treatments. As identified by Ingenuity Pathway Analysis (IPA), transcription and translation mechanisms, protein degradation via the proteasome, and cytoskeletal components were down-regulated at elevated temperature. In contrast, an up-regulated response was identified for NRF2-mediated oxidative stress, endoplasmic reticulum stress, and amino acid degradation. The proteome response was paralleled by reduced fish condition factor and hepato-somatic index at elevated temperature. Conclusions The present study provides new evidence of the interplay among different cellular machineries in a scenario of heat-induced energy deficit and oxidative stress, and refines present understanding of how Atlantic salmon cope with chronic exposure to temperature near the upper limits of thermal tolerance. Article in Journal/Newspaper Atlantic salmon University of Tasmania: UTas ePrints BMC Genomics 19 1 |
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Open Polar |
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University of Tasmania: UTas ePrints |
op_collection_id |
ftunivtasmania |
language |
English |
topic |
aquaculture Atlantic salmon climate change proteomics adaptation |
spellingShingle |
aquaculture Atlantic salmon climate change proteomics adaptation Nuez-Ortin, WG Carter, CG Nichols, PD Cooke, IR Wilson, R Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
topic_facet |
aquaculture Atlantic salmon climate change proteomics adaptation |
description |
Background Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in thermal adaptation. With the aim of identifying mechanisms underlying liver plasticity in response to chronic elevated temperature in Atlantic salmon, label-free shotgun proteomics was used to explore quantitative protein changes after 43 days of exposure to elevated temperature. Results A total of 276 proteins were differentially (adjusted p-value °C) and elevated (21 °C) temperature treatments. As identified by Ingenuity Pathway Analysis (IPA), transcription and translation mechanisms, protein degradation via the proteasome, and cytoskeletal components were down-regulated at elevated temperature. In contrast, an up-regulated response was identified for NRF2-mediated oxidative stress, endoplasmic reticulum stress, and amino acid degradation. The proteome response was paralleled by reduced fish condition factor and hepato-somatic index at elevated temperature. Conclusions The present study provides new evidence of the interplay among different cellular machineries in a scenario of heat-induced energy deficit and oxidative stress, and refines present understanding of how Atlantic salmon cope with chronic exposure to temperature near the upper limits of thermal tolerance. |
format |
Article in Journal/Newspaper |
author |
Nuez-Ortin, WG Carter, CG Nichols, PD Cooke, IR Wilson, R |
author_facet |
Nuez-Ortin, WG Carter, CG Nichols, PD Cooke, IR Wilson, R |
author_sort |
Nuez-Ortin, WG |
title |
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
title_short |
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
title_full |
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
title_fullStr |
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
title_full_unstemmed |
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature |
title_sort |
liver proteome response of pre-harvest atlantic salmon following exposure to elevated temperature |
publisher |
Biomed Central Ltd |
publishDate |
2018 |
url |
https://eprints.utas.edu.au/26190/ https://eprints.utas.edu.au/26190/1/BMC%20genomics_Nuez.pdf https://doi.org/10.1186/s12864-018-4517-0 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
https://eprints.utas.edu.au/26190/1/BMC%20genomics_Nuez.pdf Nuez-Ortin, WG, Carter, CG orcid:0000-0001-5210-1282 , Nichols, PD, Cooke, IR and Wilson, R orcid:0000-0003-0152-4394 2018 , 'Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature' , BMC Genomics, vol. 19 , pp. 1-13 , doi:10.1186/s12864-018-4517-0 <http://dx.doi.org/10.1186/s12864-018-4517-0>. |
op_doi |
https://doi.org/10.1186/s12864-018-4517-0 |
container_title |
BMC Genomics |
container_volume |
19 |
container_issue |
1 |
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1766359145763569664 |