Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma

• Published in: Nature Genetics
• Main Authors: Thorleifsson, G, Walters, GB, Hewitt, AW, Masson, G, Helgason, A, DeWan, A, Sigurdsson, A, Jonasdottir, A, Gudjonsson, SA, Magnusson, KP, Stefansson, H, Lam, DSC, Tam, POS, Gudmundsdottir, GJ, Southgate, L, Burdon, KP, Gottfredsdottir, MS, Aldred, MA, Mitchell, P, St Clair, D, Collier, DA, Tang, N, Sveinsson, O, Macgregor, S, Martin, NG, Cree, AJ, Gibson, J, MacLeod, A, Jacob, A, Ennis, S, Young, TL, Chan, JCN, Karwatowski, WSS, Hammond, CJ, Thordarson, K, Zhang, M, Wadelius, C, Lotery, AJ, Trembath, RC, Pang, CP, Hoh, J, Craig, JE, Kong, A, Mackey, DA, Jonasson, F, Thorsteinsdottir, U, Stefansson, K
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing Group 2010
• Subjects: Medical and Health Sciences; Ophthalmology and Optometry; Vision Science; Iceland
• Online Access: https://doi.org/10.1038/ng.661; http://www.ncbi.nlm.nih.gov/pubmed/20835238; http://ecite.utas.edu.au/67784

We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[A], odds ratio (OR) = 1.36, P = 5.0 '- 10 '10). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG. 2010 Nature America, Inc. All rights reserved.