Experimental vaccination of Atlantic salmon ( Salmo salar L) against marine flexibacteriosis
Tenacibaculum maritimum infections can cause losses in mariculture, however there is no commerciallyavailable vaccine in Australia. A vaccination trial was undertaken using 4 groups: Control, IP Control, Vaccine,and Vaccine + Adjuvant. Within the challenge period of 27 days, significant protection w...
| Published in: | Aquaculture |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Elsevier Science Bv
2009
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.aquaculture.2008.11.012 http://ecite.utas.edu.au/60128 |
| Summary: | Tenacibaculum maritimum infections can cause losses in mariculture, however there is no commerciallyavailable vaccine in Australia. A vaccination trial was undertaken using 4 groups: Control, IP Control, Vaccine,and Vaccine + Adjuvant. Within the challenge period of 27 days, significant protection was demonstrated infish injected with the Vaccine + Adjuvant compared to all other groups. RPS values were calculated at 79.6%and 78.0%. Fish vaccinated without adjuvant did show lower mortalities than unvaccinated fish, however, itwas not significantly different from both unvaccinated groups. Low RPS values at 27.7% and 22.0% indicatethat the vaccine without adjuvant could not provide sufficient protection from a moderate challenge ofT. maritimum. Side effects of the oil based adjuvant, Freund's incomplete adjuvant (FIA) were noted. Allfish injected with the Vaccine + Adjuvant had black/brown pigment associated with the external surfaceof the fundic region of the stomach. Histological examination revealed this material to be black/brownpigmentation most likely caused by melanin. An inflammatory response was noted around this material withthe formations of granulomas and cysts. 2008 Elsevier B.V. All rights reserved |
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