Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.)
Several important cultured marine fish are highly susceptible to an ectoparasitic condition known as amoebic gill disease (AGD). In AGD-affected fish, modulation of IL-1, p53 and p53-regulated transcripts is restricted to the (multi)focal AGD-associated gill lesions. To determine whether this lesion...
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ftunivtasecite:oai:ecite.utas.edu.au:55470 2023-05-15T15:31:39+02:00 Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) Young, ND Cooper, GA Nowak, BF Koop, BF Morrison, RN 2008 https://doi.org/10.1016/jmolimm.2007.12.023 http://www.ncbi.nlm.nih.gov/pubmed/18282602 http://ecite.utas.edu.au/55470 en eng Permagon-Elseviers Science Ltd http://dx.doi.org/10.1016/jmolimm.2007.12.023 Young, ND and Cooper, GA and Nowak, BF and Koop, BF and Morrison, RN, Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.), Molecular Immunology, 45, (9) pp. 2581 - 2597. ISSN 0161-5890 (2008) [Refereed Article] http://www.ncbi.nlm.nih.gov/pubmed/18282602 http://ecite.utas.edu.au/55470 Agricultural and Veterinary Sciences Fisheries Sciences Fish Pests and Diseases Refereed Article PeerReviewed 2008 ftunivtasecite https://doi.org/10.1016/jmolimm.2007.12.023 2019-12-13T21:28:04Z Several important cultured marine fish are highly susceptible to an ectoparasitic condition known as amoebic gill disease (AGD). In AGD-affected fish, modulation of IL-1, p53 and p53-regulated transcripts is restricted to the (multi)focal AGD-associated gill lesions. To determine whether this lesion-restricted modulation of transcripts occurs on a transcriptome-wide scale and to identify mechanisms that underpin the susceptibility of fish to AGD, we compared the transcriptome of AGD lesions with "normal" tissue from AGD-affected and healthy individuals. Global gene expression profiling using a 16 K salmonid microarray, revealed a total of 176 significantly regulated annotated features and of those, the modulation of 99 (56%) was lesion-restricted. Annotated transcripts were classified according to functional gene ontology. Within the immune response category, transcripts were almost universally down-regulated. In AGD-affected tissue, significant, coordinated down-regulation of the major histocompatibility complex class I (MHC I) pathway-related genes occurred during the later stages of infection and appeared to be mediated by down-regulation of interferon-regulatory factor (IRF)-1, independent of interferon-, interferon- and IRF-2 expression. Within this micro-environment, suppression of the MHC I and possibly the MHC II pathways may inhibit the development of acquired immunity and could explain the unusually high susceptibility of Atlantic salmon to AGD. 2008 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Atlantic salmon Salmo salar eCite UTAS (University of Tasmania) |
institution |
Open Polar |
collection |
eCite UTAS (University of Tasmania) |
op_collection_id |
ftunivtasecite |
language |
English |
topic |
Agricultural and Veterinary Sciences Fisheries Sciences Fish Pests and Diseases |
spellingShingle |
Agricultural and Veterinary Sciences Fisheries Sciences Fish Pests and Diseases Young, ND Cooper, GA Nowak, BF Koop, BF Morrison, RN Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
topic_facet |
Agricultural and Veterinary Sciences Fisheries Sciences Fish Pests and Diseases |
description |
Several important cultured marine fish are highly susceptible to an ectoparasitic condition known as amoebic gill disease (AGD). In AGD-affected fish, modulation of IL-1, p53 and p53-regulated transcripts is restricted to the (multi)focal AGD-associated gill lesions. To determine whether this lesion-restricted modulation of transcripts occurs on a transcriptome-wide scale and to identify mechanisms that underpin the susceptibility of fish to AGD, we compared the transcriptome of AGD lesions with "normal" tissue from AGD-affected and healthy individuals. Global gene expression profiling using a 16 K salmonid microarray, revealed a total of 176 significantly regulated annotated features and of those, the modulation of 99 (56%) was lesion-restricted. Annotated transcripts were classified according to functional gene ontology. Within the immune response category, transcripts were almost universally down-regulated. In AGD-affected tissue, significant, coordinated down-regulation of the major histocompatibility complex class I (MHC I) pathway-related genes occurred during the later stages of infection and appeared to be mediated by down-regulation of interferon-regulatory factor (IRF)-1, independent of interferon-, interferon- and IRF-2 expression. Within this micro-environment, suppression of the MHC I and possibly the MHC II pathways may inhibit the development of acquired immunity and could explain the unusually high susceptibility of Atlantic salmon to AGD. 2008 Elsevier Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Young, ND Cooper, GA Nowak, BF Koop, BF Morrison, RN |
author_facet |
Young, ND Cooper, GA Nowak, BF Koop, BF Morrison, RN |
author_sort |
Young, ND |
title |
Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
title_short |
Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
title_full |
Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
title_fullStr |
Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
title_full_unstemmed |
Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.) |
title_sort |
coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected atlantic salmon ( salmo salar l.) |
publisher |
Permagon-Elseviers Science Ltd |
publishDate |
2008 |
url |
https://doi.org/10.1016/jmolimm.2007.12.023 http://www.ncbi.nlm.nih.gov/pubmed/18282602 http://ecite.utas.edu.au/55470 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://dx.doi.org/10.1016/jmolimm.2007.12.023 Young, ND and Cooper, GA and Nowak, BF and Koop, BF and Morrison, RN, Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon ( Salmo salar L.), Molecular Immunology, 45, (9) pp. 2581 - 2597. ISSN 0161-5890 (2008) [Refereed Article] http://www.ncbi.nlm.nih.gov/pubmed/18282602 http://ecite.utas.edu.au/55470 |
op_doi |
https://doi.org/10.1016/jmolimm.2007.12.023 |
_version_ |
1766362178842001408 |