Antarctic isolation: Immune and viral studies
Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous de...
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Online Access: | https://doi.org/10.1038/icb.1997.42 http://www.ncbi.nlm.nih.gov/pubmed/9243293 http://ecite.utas.edu.au/10961 |
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ftunivtasecite:oai:ecite.utas.edu.au:10961 2023-05-15T13:56:40+02:00 Antarctic isolation: Immune and viral studies Tingate, TR Lugg, DJ Muller, HK Stowe, RP Pierson, DL 1997 https://doi.org/10.1038/icb.1997.42 http://www.ncbi.nlm.nih.gov/pubmed/9243293 http://ecite.utas.edu.au/10961 en eng Blackwell http://dx.doi.org/10.1038/icb.1997.42 Tingate, TR and Lugg, DJ and Muller, HK and Stowe, RP and Pierson, DL, Antarctic isolation: Immune and viral studies, Immunology and Cell Biology, 75, (3) pp. 275-283. ISSN 0818-9641 (1997) [Refereed Article] http://www.ncbi.nlm.nih.gov/pubmed/9243293 http://ecite.utas.edu.au/10961 Medical and Health Sciences Immunology Cellular Immunology Refereed Article PeerReviewed 1997 ftunivtasecite https://doi.org/10.1038/icb.1997.42 2019-12-13T20:56:12Z Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed-type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the mitogen phytohaemagglutinin, were documented during a 9-month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro-inflammatory monokine TNF- and changes were also detected in the production of IL-1, IL- 2, IL-6, IL-1ra and IL-10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein-Barr virus-infected B cell population. These findings have important long-term health implications. Article in Journal/Newspaper Antarc* Antarctic eCite UTAS (University of Tasmania) Antarctic The Antarctic Immunology and Cell Biology 75 3 275 283 |
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eCite UTAS (University of Tasmania) |
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ftunivtasecite |
language |
English |
topic |
Medical and Health Sciences Immunology Cellular Immunology |
spellingShingle |
Medical and Health Sciences Immunology Cellular Immunology Tingate, TR Lugg, DJ Muller, HK Stowe, RP Pierson, DL Antarctic isolation: Immune and viral studies |
topic_facet |
Medical and Health Sciences Immunology Cellular Immunology |
description |
Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed-type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the mitogen phytohaemagglutinin, were documented during a 9-month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro-inflammatory monokine TNF- and changes were also detected in the production of IL-1, IL- 2, IL-6, IL-1ra and IL-10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein-Barr virus-infected B cell population. These findings have important long-term health implications. |
format |
Article in Journal/Newspaper |
author |
Tingate, TR Lugg, DJ Muller, HK Stowe, RP Pierson, DL |
author_facet |
Tingate, TR Lugg, DJ Muller, HK Stowe, RP Pierson, DL |
author_sort |
Tingate, TR |
title |
Antarctic isolation: Immune and viral studies |
title_short |
Antarctic isolation: Immune and viral studies |
title_full |
Antarctic isolation: Immune and viral studies |
title_fullStr |
Antarctic isolation: Immune and viral studies |
title_full_unstemmed |
Antarctic isolation: Immune and viral studies |
title_sort |
antarctic isolation: immune and viral studies |
publisher |
Blackwell |
publishDate |
1997 |
url |
https://doi.org/10.1038/icb.1997.42 http://www.ncbi.nlm.nih.gov/pubmed/9243293 http://ecite.utas.edu.au/10961 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
http://dx.doi.org/10.1038/icb.1997.42 Tingate, TR and Lugg, DJ and Muller, HK and Stowe, RP and Pierson, DL, Antarctic isolation: Immune and viral studies, Immunology and Cell Biology, 75, (3) pp. 275-283. ISSN 0818-9641 (1997) [Refereed Article] http://www.ncbi.nlm.nih.gov/pubmed/9243293 http://ecite.utas.edu.au/10961 |
op_doi |
https://doi.org/10.1038/icb.1997.42 |
container_title |
Immunology and Cell Biology |
container_volume |
75 |
container_issue |
3 |
container_start_page |
275 |
op_container_end_page |
283 |
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1766264225712308224 |