A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the a...
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ftunivtampere:oai:trepo.tuni.fi:10024/96540 2023-05-15T17:42:50+02:00 A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia Huusko, Johanna Karjalainen, Minna Mahlman, Mari Haataja, Ritva Kari, Anneli Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal Hallman, Mikko BioMediTech - BioMediTech University of Tampere 2014 fulltext https://trepo.tuni.fi/handle/10024/96540 en eng 1471-2350 10.1186/s12881-014-0120-7 120 BMC Medical Genetics 15 https://trepo.tuni.fi/handle/10024/96540 URN:NBN:fi:uta-201412222516 This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. openAccess Lääketieteen bioteknologia - Medical biotechnology publishedVersion article 2014 ftunivtampere 2022-12-11T06:54:33Z Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes that are involved in inflammation or differentiation of the lung have influence on BPD susceptibility. Methods Genes encoding interleukin-6 (IL6) and its receptors (IL6R and IL6ST), IL-10 (IL10), tumor necrosis factor (TNF), and glucocorticoid receptor (NR3C1) were assessed for associations with moderate-to-severe BPD susceptibility. Five IL6, nine IL6R, four IL6ST, one IL10, two TNF, and 23 NR3C1 single nucleotide polymorphisms (SNPs) were analyzed in very preterm infants born in northern Finland (56 cases and 197 controls) and Canada (58 cases and 68 controls). IL-6, TNF and gp130 contents in umbilical cord blood, collected from very preterm infants, were studied for associations with the polymorphisms. Epistasis (i.e., interactions between SNPs in BPD susceptibility) was also examined. SNPs showing suggestive associations were analyzed in additional replication populations from Finland (39 cases and 188 controls) and Hungary (29 cases and 40 controls). Results None of the studied SNPs were associated with BPD nor were the IL6, TNF or IL6ST SNPs associated with cord blood IL-6, TNF and gp130, respectively. However, epistasis analysis suggested that SNPs in IL6ST and IL10 were associated interactively with risk of BPD in the northern Finnish population; however, this finding did not remain significant after correction for multiple testing and the finding was not replicated in the other populations. Conclusions We conclude that the analyzed SNPs within IL6, IL6R, IL6ST, IL10, TNF, and NR3C1 were not associated with BPD. Furthermore, there was no evidence that the studied SNPs directly contribute to the cord blood protein contents. BioMed Central ... Article in Journal/Newspaper Northern Finland Tampere University: Trepo Canada |
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Open Polar |
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Tampere University: Trepo |
op_collection_id |
ftunivtampere |
language |
English |
topic |
Lääketieteen bioteknologia - Medical biotechnology |
spellingShingle |
Lääketieteen bioteknologia - Medical biotechnology Huusko, Johanna Karjalainen, Minna Mahlman, Mari Haataja, Ritva Kari, Anneli Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal Hallman, Mikko A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
topic_facet |
Lääketieteen bioteknologia - Medical biotechnology |
description |
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease associated with very preterm birth. The major risk factors include lung inflammation and lung immaturity. In addition, genetic factors play an important role in susceptibility to moderate-to-severe BPD. In this study, the aim was to investigate whether common polymorphisms of specific genes that are involved in inflammation or differentiation of the lung have influence on BPD susceptibility. Methods Genes encoding interleukin-6 (IL6) and its receptors (IL6R and IL6ST), IL-10 (IL10), tumor necrosis factor (TNF), and glucocorticoid receptor (NR3C1) were assessed for associations with moderate-to-severe BPD susceptibility. Five IL6, nine IL6R, four IL6ST, one IL10, two TNF, and 23 NR3C1 single nucleotide polymorphisms (SNPs) were analyzed in very preterm infants born in northern Finland (56 cases and 197 controls) and Canada (58 cases and 68 controls). IL-6, TNF and gp130 contents in umbilical cord blood, collected from very preterm infants, were studied for associations with the polymorphisms. Epistasis (i.e., interactions between SNPs in BPD susceptibility) was also examined. SNPs showing suggestive associations were analyzed in additional replication populations from Finland (39 cases and 188 controls) and Hungary (29 cases and 40 controls). Results None of the studied SNPs were associated with BPD nor were the IL6, TNF or IL6ST SNPs associated with cord blood IL-6, TNF and gp130, respectively. However, epistasis analysis suggested that SNPs in IL6ST and IL10 were associated interactively with risk of BPD in the northern Finnish population; however, this finding did not remain significant after correction for multiple testing and the finding was not replicated in the other populations. Conclusions We conclude that the analyzed SNPs within IL6, IL6R, IL6ST, IL10, TNF, and NR3C1 were not associated with BPD. Furthermore, there was no evidence that the studied SNPs directly contribute to the cord blood protein contents. BioMed Central ... |
author2 |
BioMediTech - BioMediTech University of Tampere |
format |
Article in Journal/Newspaper |
author |
Huusko, Johanna Karjalainen, Minna Mahlman, Mari Haataja, Ritva Kari, Anneli Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal Hallman, Mikko |
author_facet |
Huusko, Johanna Karjalainen, Minna Mahlman, Mari Haataja, Ritva Kari, Anneli Andersson, Sture Toldi, Gergely Tammela, Outi Rämet, Mika Lavoie, Pascal Hallman, Mikko |
author_sort |
Huusko, Johanna |
title |
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
title_short |
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
title_full |
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
title_fullStr |
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
title_full_unstemmed |
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia |
title_sort |
study of genes encoding cytokines (il6, il10, tnf), cytokine receptors (il6r, il6st), and glucocorticoid receptor (nr3c1) and susceptibility to bronchopulmonary dysplasia |
publishDate |
2014 |
url |
https://trepo.tuni.fi/handle/10024/96540 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
1471-2350 10.1186/s12881-014-0120-7 120 BMC Medical Genetics 15 https://trepo.tuni.fi/handle/10024/96540 URN:NBN:fi:uta-201412222516 |
op_rights |
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. openAccess |
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1766144755814629376 |