Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae)
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by various t...
Published in: | Molecular Ecology |
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Online Access: | https://trepo.tuni.fi/handle/10024/152276 https://doi.org/10.1111/mec.16755 |
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ftunivtampere:oai:trepo.tuni.fi:10024/152276 2024-01-07T09:41:42+01:00 Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L O Tampere University BioMediTech 2023-11-01 32034980 fulltext https://trepo.tuni.fi/handle/10024/152276 https://doi.org/10.1111/mec.16755 en eng 15 32 0962-1083 ORCID: /0000-0001-6724-629X/work/127679507 https://trepo.tuni.fi/handle/10024/152276 URN:NBN:fi:tuni-202302162443 doi:10.1111/mec.16755 This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited openAccess 3111 Biomedicine 318 Medical biotechnology 1182 Biochemistry cell and molecular biology article 2023 ftunivtampere https://doi.org/10.1111/mec.16755 2023-12-14T00:09:36Z Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by various types of natural selection, making the association of genetic differences between the species with the phenotypic differences extremely complex to dissect. In the present study, we have used an in vitro model to analyse in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, the arctic/subarctic mountain hare (Lepus timidus Linnaeus) and the temperate steppe-climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1623 genes, manifesting in differences in cell growth, cell cycle control, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest that speciation acts on fundamental cellular processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Peer reviewed Article in Journal/Newspaper Arctic Lepus timidus mountain hare Subarctic Tampere University: Trepo Arctic Molecular Ecology 32 15 4097 4117 |
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Open Polar |
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Tampere University: Trepo |
op_collection_id |
ftunivtampere |
language |
English |
topic |
3111 Biomedicine 318 Medical biotechnology 1182 Biochemistry cell and molecular biology |
spellingShingle |
3111 Biomedicine 318 Medical biotechnology 1182 Biochemistry cell and molecular biology Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L O Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
topic_facet |
3111 Biomedicine 318 Medical biotechnology 1182 Biochemistry cell and molecular biology |
description |
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological and behavioural differences. Each species has travelled its own evolutionary trajectory, influenced by random drift and driven by various types of natural selection, making the association of genetic differences between the species with the phenotypic differences extremely complex to dissect. In the present study, we have used an in vitro model to analyse in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, the arctic/subarctic mountain hare (Lepus timidus Linnaeus) and the temperate steppe-climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1623 genes, manifesting in differences in cell growth, cell cycle control, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest that speciation acts on fundamental cellular processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Peer reviewed |
author2 |
Tampere University BioMediTech |
format |
Article in Journal/Newspaper |
author |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L O |
author_facet |
Gaertner, Kateryna Michell, Craig Tapanainen, Riikka Goffart, Steffi Saari, Sina Soininmäki, Manu Dufour, Eric Pohjoismäki, Jaakko L O |
author_sort |
Gaertner, Kateryna |
title |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
title_short |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
title_full |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
title_fullStr |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
title_full_unstemmed |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha : Leporidae) |
title_sort |
molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (lepus spp., lagomorpha : leporidae) |
publishDate |
2023 |
url |
https://trepo.tuni.fi/handle/10024/152276 https://doi.org/10.1111/mec.16755 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Lepus timidus mountain hare Subarctic |
genre_facet |
Arctic Lepus timidus mountain hare Subarctic |
op_relation |
15 32 0962-1083 ORCID: /0000-0001-6724-629X/work/127679507 https://trepo.tuni.fi/handle/10024/152276 URN:NBN:fi:tuni-202302162443 doi:10.1111/mec.16755 |
op_rights |
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited openAccess |
op_doi |
https://doi.org/10.1111/mec.16755 |
container_title |
Molecular Ecology |
container_volume |
32 |
container_issue |
15 |
container_start_page |
4097 |
op_container_end_page |
4117 |
_version_ |
1787422511940501504 |