Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study
Aims/hypothesis: Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods: We performed a longitudinal analysis of 38 circulating immunologic...
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ftunivtampere:oai:trepo.tuni.fi:10024/136117 2024-01-07T09:44:34+01:00 Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study Miettinen, Maija E. Honkanen, Jarno Niinistö, Sari Vaarala, Outi Virtanen, Suvi M. Knip, Mikael The DIABIMMUNE Study Group Tampere University Health Sciences Tays Research Services Department of Paediatrics 2022 462921 fulltext https://trepo.tuni.fi/handle/10024/136117 https://doi.org/10.1007/s00125-021-05612-2 en eng 65 0012-186X https://trepo.tuni.fi/handle/10024/136117 URN:NBN:fi:tuni-202112129137 doi:10.1007/s00125-021-05612-2 cc by 4.0 openAccess 3141 Health care science 3123 Gynaecology and paediatrics 3121 Internal medicine article 2022 ftunivtampere https://doi.org/10.1007/s00125-021-05612-2 2023-12-14T00:07:51Z Aims/hypothesis: Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods: We performed a longitudinal analysis of 38 circulating immunological markers (cytokines, chemokines and growth factors) in serum samples from Finnish (56 individuals, 147 samples), Estonian (56 individuals 148 samples) and Russian Karelian children (62 individuals, 149 samples) at 3, 6, 12, 18, 24 and 36 months of age. We also analysed gut inflammation markers (calprotectin and human β defensin-2) at 3 (n = 96) and 6 months (n = 153) of age. Comparisons of immunological marker medians were performed between children who were breastfed for 6 months or longer vs children who were breastfed for less than 6 months. Results: Breastfeeding for 6 months or longer vs less than 6 months was associated with lower median of serum immunological markers at 6 months (granulocyte-macrophage colony-stimulating factor [GMCSF], macrophage inflammatory protein [MIP-3α]), 12 months (IFN-α2, vascular endothelial growth factor, GMCSF, IFN-γ, IL-21), 18 months (FGF-2, IFN-α2) and 24 months of age (CCL11 [eotaxin], monocyte chemoattractant protein-1, TGFα, soluble CD40 ligand, IL-13, IL-21, IL-5, MIP-1α) (all p < 0.01) but not at 36 months of age. Breastfeeding was not associated with gut inflammation markers at 3 and 6 months of age. Conclusions/interpretation: Children who were breastfed for 6 months or longer had lower medians for 14 immunological markers at one or more age points during the first 2 years of life compared with children who were breastfed for less than 6 months. The clinical meaning of the findings is not clear. However, the present study contributes to the understanding of immunological differences in children that have been breastfed longer, and thus provides a mechanistic suggestion for the previously observed associations between breastfeeding and risk of type 1 diabetes. ... Article in Journal/Newspaper karelian Tampere University: Trepo Diabetologia 65 2 329 335 |
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Tampere University: Trepo |
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ftunivtampere |
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English |
topic |
3141 Health care science 3123 Gynaecology and paediatrics 3121 Internal medicine |
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3141 Health care science 3123 Gynaecology and paediatrics 3121 Internal medicine Miettinen, Maija E. Honkanen, Jarno Niinistö, Sari Vaarala, Outi Virtanen, Suvi M. Knip, Mikael The DIABIMMUNE Study Group Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
topic_facet |
3141 Health care science 3123 Gynaecology and paediatrics 3121 Internal medicine |
description |
Aims/hypothesis: Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods: We performed a longitudinal analysis of 38 circulating immunological markers (cytokines, chemokines and growth factors) in serum samples from Finnish (56 individuals, 147 samples), Estonian (56 individuals 148 samples) and Russian Karelian children (62 individuals, 149 samples) at 3, 6, 12, 18, 24 and 36 months of age. We also analysed gut inflammation markers (calprotectin and human β defensin-2) at 3 (n = 96) and 6 months (n = 153) of age. Comparisons of immunological marker medians were performed between children who were breastfed for 6 months or longer vs children who were breastfed for less than 6 months. Results: Breastfeeding for 6 months or longer vs less than 6 months was associated with lower median of serum immunological markers at 6 months (granulocyte-macrophage colony-stimulating factor [GMCSF], macrophage inflammatory protein [MIP-3α]), 12 months (IFN-α2, vascular endothelial growth factor, GMCSF, IFN-γ, IL-21), 18 months (FGF-2, IFN-α2) and 24 months of age (CCL11 [eotaxin], monocyte chemoattractant protein-1, TGFα, soluble CD40 ligand, IL-13, IL-21, IL-5, MIP-1α) (all p < 0.01) but not at 36 months of age. Breastfeeding was not associated with gut inflammation markers at 3 and 6 months of age. Conclusions/interpretation: Children who were breastfed for 6 months or longer had lower medians for 14 immunological markers at one or more age points during the first 2 years of life compared with children who were breastfed for less than 6 months. The clinical meaning of the findings is not clear. However, the present study contributes to the understanding of immunological differences in children that have been breastfed longer, and thus provides a mechanistic suggestion for the previously observed associations between breastfeeding and risk of type 1 diabetes. ... |
author2 |
Tampere University Health Sciences Tays Research Services Department of Paediatrics |
format |
Article in Journal/Newspaper |
author |
Miettinen, Maija E. Honkanen, Jarno Niinistö, Sari Vaarala, Outi Virtanen, Suvi M. Knip, Mikael The DIABIMMUNE Study Group |
author_facet |
Miettinen, Maija E. Honkanen, Jarno Niinistö, Sari Vaarala, Outi Virtanen, Suvi M. Knip, Mikael The DIABIMMUNE Study Group |
author_sort |
Miettinen, Maija E. |
title |
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
title_short |
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
title_full |
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
title_fullStr |
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
title_full_unstemmed |
Breastfeeding and circulating immunological markers during the first 3 years of life : the DIABIMMUNE study |
title_sort |
breastfeeding and circulating immunological markers during the first 3 years of life : the diabimmune study |
publishDate |
2022 |
url |
https://trepo.tuni.fi/handle/10024/136117 https://doi.org/10.1007/s00125-021-05612-2 |
genre |
karelian |
genre_facet |
karelian |
op_relation |
65 0012-186X https://trepo.tuni.fi/handle/10024/136117 URN:NBN:fi:tuni-202112129137 doi:10.1007/s00125-021-05612-2 |
op_rights |
cc by 4.0 openAccess |
op_doi |
https://doi.org/10.1007/s00125-021-05612-2 |
container_title |
Diabetologia |
container_volume |
65 |
container_issue |
2 |
container_start_page |
329 |
op_container_end_page |
335 |
_version_ |
1787425964063457280 |