A Sustainable Green Enzymatic Method for Amide Bond Formation
A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the nee...
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2023
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ftunivszegedir:oai:publicatio.bibl.u-szeged.hu:28021 2023-09-26T15:11:54+02:00 A Sustainable Green Enzymatic Method for Amide Bond Formation Orsy György Shahmohammadi Sayeh Forró Enikő 2023 text http://publicatio.bibl.u-szeged.hu/28021/ http://publicatio.bibl.u-szeged.hu/28021/1/Molecules_5706_Orsy_2023.pdf https://doi.org/10.3390/molecules28155706 eng eng http://publicatio.bibl.u-szeged.hu/28021/1/Molecules_5706_Orsy_2023.pdf Orsy György; Shahmohammadi Sayeh; Forró Enikő: A Sustainable Green Enzymatic Method for Amide Bond Formation. MOLECULES, 28 (15). ISSN 1420-3049 (2023) doi:10.3390/molecules28155706 info:eu-repo/semantics/openAccess 01.04. Kémiai tudományok Folyóiratcikk PeerReviewed 2023 ftunivszegedir https://doi.org/10.3390/molecules28155706 2023-08-27T20:46:04Z A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. Article in Journal/Newspaper Antarc* Antarctica University of Szeged: SZTE Repository of Publications Molecules 28 15 5706 |
institution |
Open Polar |
collection |
University of Szeged: SZTE Repository of Publications |
op_collection_id |
ftunivszegedir |
language |
English |
topic |
01.04. Kémiai tudományok |
spellingShingle |
01.04. Kémiai tudományok Orsy György Shahmohammadi Sayeh Forró Enikő A Sustainable Green Enzymatic Method for Amide Bond Formation |
topic_facet |
01.04. Kémiai tudományok |
description |
A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides with excellent conversions and yields without the need for intensive purification steps. The scope of the reaction was extended to the preparation of 28 diverse amides using four different free carboxylic acids and seven primary and secondary amines, including cyclic amines. This enzymatic methodology has the potential to become a green and industrially reliable process for direct amide synthesis. |
format |
Article in Journal/Newspaper |
author |
Orsy György Shahmohammadi Sayeh Forró Enikő |
author_facet |
Orsy György Shahmohammadi Sayeh Forró Enikő |
author_sort |
Orsy György |
title |
A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_short |
A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_full |
A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_fullStr |
A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_full_unstemmed |
A Sustainable Green Enzymatic Method for Amide Bond Formation |
title_sort |
sustainable green enzymatic method for amide bond formation |
publishDate |
2023 |
url |
http://publicatio.bibl.u-szeged.hu/28021/ http://publicatio.bibl.u-szeged.hu/28021/1/Molecules_5706_Orsy_2023.pdf https://doi.org/10.3390/molecules28155706 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://publicatio.bibl.u-szeged.hu/28021/1/Molecules_5706_Orsy_2023.pdf Orsy György; Shahmohammadi Sayeh; Forró Enikő: A Sustainable Green Enzymatic Method for Amide Bond Formation. MOLECULES, 28 (15). ISSN 1420-3049 (2023) doi:10.3390/molecules28155706 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/molecules28155706 |
container_title |
Molecules |
container_volume |
28 |
container_issue |
15 |
container_start_page |
5706 |
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1778132415781273600 |