Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up
Background: Podoconiosis is a non-filarial elephantiasis caused by long-term barefoot exposure to volcanic soils in endemic areas. Irritant silicate particles penetrate the skin, causing a progressive, debilitating lymphoedema of the lower leg, often starting in the second decade of life. A simple p...
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ftunivsussex:oai:sro.sussex.ac.uk:7307 2023-07-30T04:02:08+02:00 Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up Sikorski, Catherine Ashine, Meskele Zeleke, Zewdie Davey, Gail 2010-11 application/pdf http://sro.sussex.ac.uk/id/eprint/7307/ http://sro.sussex.ac.uk/id/eprint/7307/1/journal.pntd.0000902.pdf https://doi.org/10.1371/journal.pntd.0000902 en eng Public Library of Science http://sro.sussex.ac.uk/id/eprint/7307/1/journal.pntd.0000902.pdf Sikorski, Catherine, Ashine, Meskele, Zeleke, Zewdie and Davey, Gail (2010) Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up. PLoS Neglected Tropical Diseases, 4 (11). e902. ISSN 1935-2727 cc_by RC0109 Infectious and parasitic diseases RC0955 Arctic medicine. Tropical medicine Article PeerReviewed 2010 ftunivsussex https://doi.org/10.1371/journal.pntd.0000902 2023-07-11T20:08:06Z Background: Podoconiosis is a non-filarial elephantiasis caused by long-term barefoot exposure to volcanic soils in endemic areas. Irritant silicate particles penetrate the skin, causing a progressive, debilitating lymphoedema of the lower leg, often starting in the second decade of life. A simple patient-led treatment approach appropriate for resource poor settings has been developed, comprising (1) education on aetiology and prevention of podoconiosis, (2) foot hygiene (daily washing with soap, water and an antiseptic), (3) the regular use of emollient, (4) elevation of the limb at night, and (5) emphasis on the consistent use of shoes and socks. Methodology/Principal Findings: We did a 12-month, non-comparative, longitudinal evaluation of 33 patients newly presenting to one clinic site of a non-government organization (the Mossy Foot Treatment & Prevention Association, MFTPA) in southern Ethiopia. Outcome measures used for the monitoring of disease progress were (1) the clinical staging system for podoconiosis, and (2) the Amharic Dermatology Life Quality Index (DLQI), both of which have been recently validated for use in this setting. Digital photographs were also taken at each visit. Twenty-seven patients completed follow up. Characteristics of patients completing follow-up were not significantly different to those not. Mean clinical stage and lower leg circumference decreased significantly (mean difference -0.67 (95% CI -0.38 to -0.96) and -2.00 (95% CI -1.26 to -2.74), respectively, p<0.001 for both changes). Mean DLQI diminished from 21 (out of a maximum of 30) to 6 (p<0.001). There was a non-significant change in proportion of patients with mossy lesions (p = 0.375). Conclusions/Significance: This simple, resource-appropriate regimen has a considerable impact both on clinical progression and self-reported quality of life of affected individuals. The regimen appears ideal for scaling up to other endemic regions in Ethiopia and internationally. We recommend that further research in the area ... Article in Journal/Newspaper Arctic University of Sussex: Sussex Research Online Arctic PLoS Neglected Tropical Diseases 4 11 e902 |
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Open Polar |
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University of Sussex: Sussex Research Online |
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ftunivsussex |
language |
English |
topic |
RC0109 Infectious and parasitic diseases RC0955 Arctic medicine. Tropical medicine |
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RC0109 Infectious and parasitic diseases RC0955 Arctic medicine. Tropical medicine Sikorski, Catherine Ashine, Meskele Zeleke, Zewdie Davey, Gail Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
topic_facet |
RC0109 Infectious and parasitic diseases RC0955 Arctic medicine. Tropical medicine |
description |
Background: Podoconiosis is a non-filarial elephantiasis caused by long-term barefoot exposure to volcanic soils in endemic areas. Irritant silicate particles penetrate the skin, causing a progressive, debilitating lymphoedema of the lower leg, often starting in the second decade of life. A simple patient-led treatment approach appropriate for resource poor settings has been developed, comprising (1) education on aetiology and prevention of podoconiosis, (2) foot hygiene (daily washing with soap, water and an antiseptic), (3) the regular use of emollient, (4) elevation of the limb at night, and (5) emphasis on the consistent use of shoes and socks. Methodology/Principal Findings: We did a 12-month, non-comparative, longitudinal evaluation of 33 patients newly presenting to one clinic site of a non-government organization (the Mossy Foot Treatment & Prevention Association, MFTPA) in southern Ethiopia. Outcome measures used for the monitoring of disease progress were (1) the clinical staging system for podoconiosis, and (2) the Amharic Dermatology Life Quality Index (DLQI), both of which have been recently validated for use in this setting. Digital photographs were also taken at each visit. Twenty-seven patients completed follow up. Characteristics of patients completing follow-up were not significantly different to those not. Mean clinical stage and lower leg circumference decreased significantly (mean difference -0.67 (95% CI -0.38 to -0.96) and -2.00 (95% CI -1.26 to -2.74), respectively, p<0.001 for both changes). Mean DLQI diminished from 21 (out of a maximum of 30) to 6 (p<0.001). There was a non-significant change in proportion of patients with mossy lesions (p = 0.375). Conclusions/Significance: This simple, resource-appropriate regimen has a considerable impact both on clinical progression and self-reported quality of life of affected individuals. The regimen appears ideal for scaling up to other endemic regions in Ethiopia and internationally. We recommend that further research in the area ... |
format |
Article in Journal/Newspaper |
author |
Sikorski, Catherine Ashine, Meskele Zeleke, Zewdie Davey, Gail |
author_facet |
Sikorski, Catherine Ashine, Meskele Zeleke, Zewdie Davey, Gail |
author_sort |
Sikorski, Catherine |
title |
Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
title_short |
Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
title_full |
Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
title_fullStr |
Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
title_full_unstemmed |
Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up |
title_sort |
effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern ethiopia: one year follow-up |
publisher |
Public Library of Science |
publishDate |
2010 |
url |
http://sro.sussex.ac.uk/id/eprint/7307/ http://sro.sussex.ac.uk/id/eprint/7307/1/journal.pntd.0000902.pdf https://doi.org/10.1371/journal.pntd.0000902 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
http://sro.sussex.ac.uk/id/eprint/7307/1/journal.pntd.0000902.pdf Sikorski, Catherine, Ashine, Meskele, Zeleke, Zewdie and Davey, Gail (2010) Effectiveness of a simple lymphoedema treatment regimen in podoconiosis management in southern Ethiopia: one year follow-up. PLoS Neglected Tropical Diseases, 4 (11). e902. ISSN 1935-2727 |
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cc_by |
op_doi |
https://doi.org/10.1371/journal.pntd.0000902 |
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PLoS Neglected Tropical Diseases |
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4 |
container_issue |
11 |
container_start_page |
e902 |
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