Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection
Cetacean morbilliviruses (CeMVs) are significant causes of mortality in many cetacean species in epizootics and smaller outbreaks. Despite the prominence of skin lesions in seals and terrestrial animals, including humans, affected by other morbilliviruses, they have not been reported in CeMV-infecte...
Published in: | Journal of Comparative Pathology |
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ftunivstirling:oai:dspace.stir.ac.uk:1893/32491 2023-05-15T15:36:34+02:00 Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection Dagleish, Mark P Perri, Adele Maley, Madeleine Ballingall, Keith T Baily, Johanna L Davison, Nicholas J Brownlow, Andrew C Rocchi, Mara S Moredun Research Institute The Moredun Research Institute Institute of Aquaculture Scotland's Rural College (SRUC) orcid:0000-0001-6909-6467 orcid:0000-0002-9230-0179 orcid:0000-0001-6920-8369 orcid:0000-0002-2242-7078 orcid:0000-0001-9885-7480 2021-02 application/pdf http://hdl.handle.net/1893/32491 https://doi.org/10.1016/j.jcpa.2021.01.005 http://dspace.stir.ac.uk/bitstream/1893/32491/1/YJCPA-S-20-00376.pdf en eng Elsevier BV Dagleish MP, Perri A, Maley M, Ballingall KT, Baily JL, Davison NJ, Brownlow AC & Rocchi MS (2021) Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection. Journal of Comparative Pathology, 183, pp. 57-62. https://doi.org/10.1016/j.jcpa.2021.01.005 http://hdl.handle.net/1893/32491 doi:10.1016/j.jcpa.2021.01.005 33714433 WOS:000631997000008 2-s2.0-85101391749 1707862 http://dspace.stir.ac.uk/bitstream/1893/32491/1/YJCPA-S-20-00376.pdf This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Dagleish MP, Perri A, Maley M, Ballingall KT, Baily JL, Davison NJ, Brownlow AC & Rocchi MS (2021) Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection. Journal of Comparative Pathology, 183, pp. 57-62. https://doi.org/10.1016/j.jcpa.2021.01.005 © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-02-20 [YJCPA-S-20-00376.pdf] Publisher requires embargo of 12 months after formal publication. CC-BY-NC-ND Pathology and Forensic Medicine General Veterinary Marine Microbiology Journal Article AM - Accepted Manuscript 2021 ftunivstirling https://doi.org/10.1016/j.jcpa.2021.01.005 2022-06-13T18:43:58Z Cetacean morbilliviruses (CeMVs) are significant causes of mortality in many cetacean species in epizootics and smaller outbreaks. Despite the prominence of skin lesions in seals and terrestrial animals, including humans, affected by other morbilliviruses, they have not been reported in CeMV-infected cetaceans. Here we report CeMV-associated skin lesions in a fin whale (Balaenoptera physalus) with subacute, systemic CeMV infection that live-stranded in Scotland, UK. Grossly, the skin was sloughing in large sheets, presumed due to autolysis, but histological examination showed syncytia, below the dermoepidermal junction, that were strongly immunopositive for morbillivirus antigen, as were syncytia in other organs. By polymerase chain reaction (PCR), the relative load of CeMV-specific RNA was largest in the liver and urinary bladder, even in formalin-fixed, paraffin-wax embedded samples. Levels were low in skin and only detectable in frozen samples. Genetic comparison of the CeMV revealed close alignment with isolates from fin whales from the North Atlantic Ocean and Mediterranean Sea, but that it was distinct from the porpoise CeMV clade. These findings show skin samples can be used to diagnose CeMV infection in cetaceans, highlighting the potential of ante-mortem sampling for monitoring disease in current populations and assessment of changes in host and pathogen genetics. Article in Journal/Newspaper Balaenoptera physalus Fin whale North Atlantic University of Stirling: Stirling Digital Research Repository Journal of Comparative Pathology 183 57 62 |
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Open Polar |
collection |
University of Stirling: Stirling Digital Research Repository |
op_collection_id |
ftunivstirling |
language |
English |
topic |
Pathology and Forensic Medicine General Veterinary Marine Microbiology |
spellingShingle |
Pathology and Forensic Medicine General Veterinary Marine Microbiology Dagleish, Mark P Perri, Adele Maley, Madeleine Ballingall, Keith T Baily, Johanna L Davison, Nicholas J Brownlow, Andrew C Rocchi, Mara S Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
topic_facet |
Pathology and Forensic Medicine General Veterinary Marine Microbiology |
description |
Cetacean morbilliviruses (CeMVs) are significant causes of mortality in many cetacean species in epizootics and smaller outbreaks. Despite the prominence of skin lesions in seals and terrestrial animals, including humans, affected by other morbilliviruses, they have not been reported in CeMV-infected cetaceans. Here we report CeMV-associated skin lesions in a fin whale (Balaenoptera physalus) with subacute, systemic CeMV infection that live-stranded in Scotland, UK. Grossly, the skin was sloughing in large sheets, presumed due to autolysis, but histological examination showed syncytia, below the dermoepidermal junction, that were strongly immunopositive for morbillivirus antigen, as were syncytia in other organs. By polymerase chain reaction (PCR), the relative load of CeMV-specific RNA was largest in the liver and urinary bladder, even in formalin-fixed, paraffin-wax embedded samples. Levels were low in skin and only detectable in frozen samples. Genetic comparison of the CeMV revealed close alignment with isolates from fin whales from the North Atlantic Ocean and Mediterranean Sea, but that it was distinct from the porpoise CeMV clade. These findings show skin samples can be used to diagnose CeMV infection in cetaceans, highlighting the potential of ante-mortem sampling for monitoring disease in current populations and assessment of changes in host and pathogen genetics. |
author2 |
Moredun Research Institute The Moredun Research Institute Institute of Aquaculture Scotland's Rural College (SRUC) orcid:0000-0001-6909-6467 orcid:0000-0002-9230-0179 orcid:0000-0001-6920-8369 orcid:0000-0002-2242-7078 orcid:0000-0001-9885-7480 |
format |
Article in Journal/Newspaper |
author |
Dagleish, Mark P Perri, Adele Maley, Madeleine Ballingall, Keith T Baily, Johanna L Davison, Nicholas J Brownlow, Andrew C Rocchi, Mara S |
author_facet |
Dagleish, Mark P Perri, Adele Maley, Madeleine Ballingall, Keith T Baily, Johanna L Davison, Nicholas J Brownlow, Andrew C Rocchi, Mara S |
author_sort |
Dagleish, Mark P |
title |
Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
title_short |
Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
title_full |
Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
title_fullStr |
Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
title_full_unstemmed |
Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection |
title_sort |
novel dermatitis and relative viral nucleic acid tissue loads in a fin whale (balaenoptera physalus) with systemic cetacean morbillivirus infection |
publisher |
Elsevier BV |
publishDate |
2021 |
url |
http://hdl.handle.net/1893/32491 https://doi.org/10.1016/j.jcpa.2021.01.005 http://dspace.stir.ac.uk/bitstream/1893/32491/1/YJCPA-S-20-00376.pdf |
genre |
Balaenoptera physalus Fin whale North Atlantic |
genre_facet |
Balaenoptera physalus Fin whale North Atlantic |
op_relation |
Dagleish MP, Perri A, Maley M, Ballingall KT, Baily JL, Davison NJ, Brownlow AC & Rocchi MS (2021) Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection. Journal of Comparative Pathology, 183, pp. 57-62. https://doi.org/10.1016/j.jcpa.2021.01.005 http://hdl.handle.net/1893/32491 doi:10.1016/j.jcpa.2021.01.005 33714433 WOS:000631997000008 2-s2.0-85101391749 1707862 http://dspace.stir.ac.uk/bitstream/1893/32491/1/YJCPA-S-20-00376.pdf |
op_rights |
This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Dagleish MP, Perri A, Maley M, Ballingall KT, Baily JL, Davison NJ, Brownlow AC & Rocchi MS (2021) Novel Dermatitis and Relative Viral Nucleic Acid Tissue Loads in a Fin Whale (Balaenoptera physalus) with Systemic Cetacean Morbillivirus Infection. Journal of Comparative Pathology, 183, pp. 57-62. https://doi.org/10.1016/j.jcpa.2021.01.005 © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ 2022-02-20 [YJCPA-S-20-00376.pdf] Publisher requires embargo of 12 months after formal publication. |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.jcpa.2021.01.005 |
container_title |
Journal of Comparative Pathology |
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183 |
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