miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection

• Published in: Frontiers in Immunology
• Main Authors: Woldemariam, Nardos Tesfaye, Agafonov, Oleg, Sindre, Hilde, Høyheim, Bjørn, Houston, Ross D, Robledo, Diego, Bron, James E, Andreassen, Rune
• Other Authors: Norges Forskningsråd, Oslo Metropolitan University, University of Oslo, Norwegian Veterinary Institute, Norwegian University of Life Sciences, University of Edinburgh, Institute of Aquaculture, orcid:0000-0003-3544-0519
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media SA 2020
• Subjects: Atlantic salmon; microRNA; IPNV; immune response; host-virus interactions; Ikka
• Online Access: http://hdl.handle.net/1893/31734; https://doi.org/10.3389/fimmu.2020.02113; http://dspace.stir.ac.uk/bitstream/1893/31734/1/fimmu-11-02113.pdf

Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host mi...