Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar)
Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors,...
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Online Access: | http://hdl.handle.net/1893/31437 https://doi.org/10.1371/journal.pone.0119730 http://dspace.stir.ac.uk/bitstream/1893/31437/1/journal.pone.0119730.PDF |
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ftunivstirling:oai:dspace.stir.ac.uk:1893/31437 2023-05-15T15:30:17+02:00 Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) Gutierrez, Alejandro P Yáñez, José M Fukui, Steve Swift, Bruce Davidson, William S Simon Fraser University Universidad de Chile Cermaq Canada TRI-GEN Fish Improvement Ltd 2015 application/pdf http://hdl.handle.net/1893/31437 https://doi.org/10.1371/journal.pone.0119730 http://dspace.stir.ac.uk/bitstream/1893/31437/1/journal.pone.0119730.PDF en eng Public Library of Science (PLoS) Gutierrez AP, Yáñez JM, Fukui S, Swift B & Davidson WS (2015) Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar). PLOS ONE, 10 (3), Art. No.: e0119730. https://doi.org/10.1371/journal.pone.0119730 e0119730 http://hdl.handle.net/1893/31437 doi:10.1371/journal.pone.0119730 25757012 WOS:000351275700051 2-s2.0-84924411949 1643554 http://dspace.stir.ac.uk/bitstream/1893/31437/1/journal.pone.0119730.PDF © 2015 Gutierrez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited http://creativecommons.org/licenses/by/4.0/ CC-BY Journal Article VoR - Version of Record 2015 ftunivstirling https://doi.org/10.1371/journal.pone.0119730 2022-06-13T18:45:03Z Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼480 individuals from the Cermaq Canada broodstock program and search for SNPs associated with growth and age at sexual maturation. Using a mixed model approach we identified markers showing a significant association with growth, grilsing (early sexual maturation) and late sexual maturation. The most significant associations were found for grilsing, with markers located in Ssa10, Ssa02, Ssa13, Ssa25 and Ssa12, and for late maturation with markers located in Ssa28, Ssa01 and Ssa21. A lower level of association was detected with growth on Ssa13. Candidate genes, which were linked to these genetic markers, were identified and some of them show a direct relationship with developmental processes, especially for those in association with sexual maturation. However, the relatively low power to detect genetic markers associated with growth (days to 5 kg) in this GWAS indicates the need to use a higher density SNP array in order to overcome the low levels of linkage disequilibrium observed in Atlantic salmon before the information can be incorporated into a selective breeding program. Article in Journal/Newspaper Atlantic salmon Salmo salar University of Stirling: Stirling Digital Research Repository Canada PLOS ONE 10 3 e0119730 |
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Open Polar |
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University of Stirling: Stirling Digital Research Repository |
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ftunivstirling |
language |
English |
description |
Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼480 individuals from the Cermaq Canada broodstock program and search for SNPs associated with growth and age at sexual maturation. Using a mixed model approach we identified markers showing a significant association with growth, grilsing (early sexual maturation) and late sexual maturation. The most significant associations were found for grilsing, with markers located in Ssa10, Ssa02, Ssa13, Ssa25 and Ssa12, and for late maturation with markers located in Ssa28, Ssa01 and Ssa21. A lower level of association was detected with growth on Ssa13. Candidate genes, which were linked to these genetic markers, were identified and some of them show a direct relationship with developmental processes, especially for those in association with sexual maturation. However, the relatively low power to detect genetic markers associated with growth (days to 5 kg) in this GWAS indicates the need to use a higher density SNP array in order to overcome the low levels of linkage disequilibrium observed in Atlantic salmon before the information can be incorporated into a selective breeding program. |
author2 |
Simon Fraser University Universidad de Chile Cermaq Canada TRI-GEN Fish Improvement Ltd |
format |
Article in Journal/Newspaper |
author |
Gutierrez, Alejandro P Yáñez, José M Fukui, Steve Swift, Bruce Davidson, William S |
spellingShingle |
Gutierrez, Alejandro P Yáñez, José M Fukui, Steve Swift, Bruce Davidson, William S Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
author_facet |
Gutierrez, Alejandro P Yáñez, José M Fukui, Steve Swift, Bruce Davidson, William S |
author_sort |
Gutierrez, Alejandro P |
title |
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
title_short |
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
title_full |
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
title_fullStr |
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar) |
title_sort |
genome-wide association study (gwas) for growth rate and age at sexual maturation in atlantic salmon (salmo salar) |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
http://hdl.handle.net/1893/31437 https://doi.org/10.1371/journal.pone.0119730 http://dspace.stir.ac.uk/bitstream/1893/31437/1/journal.pone.0119730.PDF |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Gutierrez AP, Yáñez JM, Fukui S, Swift B & Davidson WS (2015) Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar). PLOS ONE, 10 (3), Art. No.: e0119730. https://doi.org/10.1371/journal.pone.0119730 e0119730 http://hdl.handle.net/1893/31437 doi:10.1371/journal.pone.0119730 25757012 WOS:000351275700051 2-s2.0-84924411949 1643554 http://dspace.stir.ac.uk/bitstream/1893/31437/1/journal.pone.0119730.PDF |
op_rights |
© 2015 Gutierrez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0119730 |
container_title |
PLOS ONE |
container_volume |
10 |
container_issue |
3 |
container_start_page |
e0119730 |
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1766360732871426048 |