Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis
The salmon louse Lepeophtheirus salmonis (Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of informati...
Published in: | Parasite Immunology |
---|---|
Main Authors: | , , |
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2020
|
Subjects: | |
Online Access: | http://hdl.handle.net/1893/31191 https://doi.org/10.1111/pim.12731 http://dspace.stir.ac.uk/bitstream/1893/31191/1/Braden%20et%20al%202020%20-%20REVIEW%20-%20Sea%20lice%20immunmodulation.pdf |
id |
ftunivstirling:oai:dspace.stir.ac.uk:1893/31191 |
---|---|
record_format |
openpolar |
spelling |
ftunivstirling:oai:dspace.stir.ac.uk:1893/31191 2023-05-15T15:29:09+02:00 Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis Braden, Laura M Monaghan, Sean J Fast, Mark D University of Prince Edward Island Institute of Aquaculture orcid:0000-0002-7692-7756 2020-08 application/pdf http://hdl.handle.net/1893/31191 https://doi.org/10.1111/pim.12731 http://dspace.stir.ac.uk/bitstream/1893/31191/1/Braden%20et%20al%202020%20-%20REVIEW%20-%20Sea%20lice%20immunmodulation.pdf en eng Wiley Braden LM, Monaghan SJ & Fast MD (2020) Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite Immunology, 42 (8: Special Issue: Fish Immunology and Parasitic Diseases), Art. No.: e12731. https://doi.org/10.1111/pim.12731 e12731 http://hdl.handle.net/1893/31191 doi:10.1111/pim.12731 32403169 WOS:000543790700001 2-s2.0-85087206762 1622270 http://dspace.stir.ac.uk/bitstream/1893/31191/1/Braden%20et%20al%202020%20-%20REVIEW%20-%20Sea%20lice%20immunmodulation.pdf This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. 2021-05-14 [Braden et al 2020 - REVIEW - Sea lice immunmodulation.pdf] Publisher requires embargo of 12 months after formal publication. aquaculture Atlantic salmon host‐parasite relationship immunomodulation Salmon lice virulence Journal Article AM - Accepted Manuscript 2020 ftunivstirling https://doi.org/10.1111/pim.12731 2022-06-13T18:46:13Z The salmon louse Lepeophtheirus salmonis (Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists and early pro‐inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host‐parasite relationship in favour of the host, preventing severe immune‐physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co‐evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here we review host‐parasite interactions at the primary attachment/feeding site, and the complex life‐stage dependent molecular mechanisms employed to subvert host physiology and immune responses. Article in Journal/Newspaper Atlantic salmon University of Stirling: Stirling Digital Research Repository Parasite Immunology 42 8 |
institution |
Open Polar |
collection |
University of Stirling: Stirling Digital Research Repository |
op_collection_id |
ftunivstirling |
language |
English |
topic |
aquaculture Atlantic salmon host‐parasite relationship immunomodulation Salmon lice virulence |
spellingShingle |
aquaculture Atlantic salmon host‐parasite relationship immunomodulation Salmon lice virulence Braden, Laura M Monaghan, Sean J Fast, Mark D Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
topic_facet |
aquaculture Atlantic salmon host‐parasite relationship immunomodulation Salmon lice virulence |
description |
The salmon louse Lepeophtheirus salmonis (Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists and early pro‐inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host‐parasite relationship in favour of the host, preventing severe immune‐physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co‐evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here we review host‐parasite interactions at the primary attachment/feeding site, and the complex life‐stage dependent molecular mechanisms employed to subvert host physiology and immune responses. |
author2 |
University of Prince Edward Island Institute of Aquaculture orcid:0000-0002-7692-7756 |
format |
Article in Journal/Newspaper |
author |
Braden, Laura M Monaghan, Sean J Fast, Mark D |
author_facet |
Braden, Laura M Monaghan, Sean J Fast, Mark D |
author_sort |
Braden, Laura M |
title |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_short |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_full |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_fullStr |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_full_unstemmed |
Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis |
title_sort |
salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite lepeophtheirus salmonis |
publisher |
Wiley |
publishDate |
2020 |
url |
http://hdl.handle.net/1893/31191 https://doi.org/10.1111/pim.12731 http://dspace.stir.ac.uk/bitstream/1893/31191/1/Braden%20et%20al%202020%20-%20REVIEW%20-%20Sea%20lice%20immunmodulation.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
Braden LM, Monaghan SJ & Fast MD (2020) Salmon immunological defence and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite Immunology, 42 (8: Special Issue: Fish Immunology and Parasitic Diseases), Art. No.: e12731. https://doi.org/10.1111/pim.12731 e12731 http://hdl.handle.net/1893/31191 doi:10.1111/pim.12731 32403169 WOS:000543790700001 2-s2.0-85087206762 1622270 http://dspace.stir.ac.uk/bitstream/1893/31191/1/Braden%20et%20al%202020%20-%20REVIEW%20-%20Sea%20lice%20immunmodulation.pdf |
op_rights |
This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. 2021-05-14 [Braden et al 2020 - REVIEW - Sea lice immunmodulation.pdf] Publisher requires embargo of 12 months after formal publication. |
op_doi |
https://doi.org/10.1111/pim.12731 |
container_title |
Parasite Immunology |
container_volume |
42 |
container_issue |
8 |
_version_ |
1766359529415507968 |